Ejlersenlauritsen1359

Both the political appetite for a science-based coronavirus disease 2019 (COVID-19) policy and its acceptability to the public are little understood, at a time of sharp distrust not only of governments but also of scientists and their journals' review practices. We studied the case of France, where the independent Scientific Council on COVID-19 was appointed by President Macron on March 12, 2020.

We conducted a survey on a representative sample of the French adult population.

Our data were collected by the French Institute of Public Opinion using a self-administered online questionnaire. This was completed by a sample of 1016 people stratified to match French official census statistics for gender, age, occupation, and so on. We conducted statistical analysis using Python (Pandas-SciPy-Statsmodels) with Chi-squared and Wilcoxon rank-sum tests to control for statistical significance.

Intense media coverage has given the council a very high public profile, with three respondents out of four (73%) having een scientific knowledge, uncertainty, and political decision-making to be understood and accounted for would greatly benefit evidence-based policy in future crises.

Our study confirms that while the transparency of scientific advice is important, it alone cannot ensure public confidence in political decision-making. We suggest that efforts made today to instill a 'science-savvy' public culture-one that allows the complex articulation between scientific knowledge, uncertainty, and political decision-making to be understood and accounted for would greatly benefit evidence-based policy in future crises.

The aim of the study was to explore acute care utilisation towards end of life by and the place of death for patients with serious mental disorders and to demonstrate any inequalities in end-of-life care faced by this patient group.

This is a retrospective cohort study using linked, routinely collected data.

This study used linked data extracted from mental health records, Hospital Episode Statistics and mortality data. Adult cases (≥18 years old) were included if they had a serious mental disorder and died between 2007 and 2015. Multiple imputation was used to manage missing data, and generalised linear models were used to assess multiple adjusted associations between sociodemographic and clinical explanatory variables and acute service use at the end of life and in-hospital deaths.

A cohort of 1350 adults was analysed. More than half visited the accident and emergency (A&E) department in the last 90 days of life, and a third had a burdensome transition (multiple hospital admissions in the last 91.10]), burdensome transitions (adjusted OR=1.53 [1.37-1.71]) and days spent in the hospital (adjusted OR=2.05 [1.70-247]).

People with comorbidities are more likely to use more burdensome acute health care at theend of life and are more likely to die in the hospital. Hospital deaths could be reduced, and end-of-life care could be improved by targeting patients with comorbidities and who are accessing more acute healthcare services.

People with comorbidities are more likely to use more burdensome acute health care at the end of life and are more likely to die in the hospital. Hospital deaths could be reduced, and end-of-life care could be improved by targeting patients with comorbidities and who are accessing more acute healthcare services.The incidence of autoimmune diseases is increasing worldwide, thus stimulating studies on their etiopathogenesis, derived from a complex interaction between genetic and environmental factors. Genetic association studies have shown the PTPN22 gene as a shared genetic risk factor with implications in multiple autoimmune disorders. By encoding a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems, the PTPN22 gene may have a fundamental role in the development of immune dysfunction. PTPN22 polymorphisms are associated with rheumatoid arthritis, type 1 diabetes, systemic lupus erythematosus, and many other autoimmune conditions. In this review, we discuss the progress in our understanding of how PTPN22 impacts autoimmunity in both humans and animal models. In addition, we highlight the pathogenic significance of the PTPN22 gene, with particular emphasis on its role in T and B cells, and its function in innate immune cells, such as monocytes, dendritic and natural killer cells. We focus particularly on the complexity of PTPN22 interplay with biological processes of the immune system. Findings highlight the importance of studying the function of disease-associated PTPN22 variants in different cell types and open new avenues of investigation with the potential to drive further insights into mechanisms of PTPN22. These new insights will reveal important clues to the molecular mechanisms of prevalent autoimmune diseases and propose new potential therapeutic targets.Lilium is an important commercial flowering species, and there are many varieties and more than 100 species of wild Lilium. Lilium × formolongi is usually propagated from seedlings, and the flowering of these plants is driven mainly by the photoperiodic pathway. Most of the other lily plants are propagated via bulblets and need to be vernalized; these plants can be simply divided into pretransplantation types and posttransplantation types according to the time at which the floral transition occurs. We identified three Lilium FLOWERING LOCUS T (LFT) family members in 7 Lilium varieties, and for each gene, the coding sequence of the different varieties was identical. Among these genes, the LFT1 gene of Lilium was most homologous to the AtFT gene, which promotes flowering in Arabidopsis. We analyzed the expression patterns of LFT genes in Lilium × formolongi seedlings and in different Lilium varieties, and the results showed that LFT1 and LFT3 may promote floral induction. Compared with LFT3, LFT1 may have a greater effect on floral induction in Lilium, which is photoperiod sensitive, while LFT3 may play a more important role in the floral transition of lily plants, which have a high requirement for vernalization. LFT2 may be involved in the differentiation of bulblets, which was verified by tissue culture experiments, and LFT1 may have other functions involved in promoting bulblet growth. The functions of LFT genes were verified by the use of transgenic Arabidopsis thaliana plants, which showed that both the LFT1 and LFT3 genes can promote early flowering in Arabidopsis. Compared with LFT3, LFT1 promoted flowering more obviously, and thus, this gene could be an important promoter of floral induction in Lilium.This study aims at investigating the specific ion effects of Na+ and K+ on Ulva lactuca (L.) growth. U. lactuca was grown in balanced nutrient solutions with 10, 100, 300 and 600 mM NaCl or KCl. The growth was significantly higher at 300 and 600 mM NaCl compared to KCl, with the highest growth rate at 300 mM NaCl. NaCl-treated alga showed increases in the photosynthetic pigments and Rubisco protein content. However, KCl treatments adversely affected these photosynthetic attributes. U. lactuca needs adjusted, but not high K+/Na+ ratio for a proper growth, since the high K+/Na+ ratio in KCl-treated alga was associated with growth retardation. The cell wall was more extensible at high concentrations of NaCl compared to KCl. Therefore, the deleterious effect of K+ could be mainly on the cell wall and hence inhibiting the growth and perhaps the vitality of the whole cell. The transcript of plasma membrane (PM) H+-ATPase was detected only at 300 and 600 mM NaCl, implying that this gene was specifically induced by high concentrations of Na+ but not K+. The transcript of PM-Na+/K+-ATPase-like exhibited no Na+ specificity and its induction alone could not improve the growth of KCl-treated U. lactuca. The simultaneous induction of the two PM-ATPases could positively affect the algal growth at high NaCl concentrations by maintaining the proper cellular K+/Na+ ratio. Also, both PM-ATPases might contribute to energizing the plasma membrane and thereby promoting the cellular growth of U. lactuca at high Na+, but not K+, concentrations.Eye movement studies show that humans can make very fast saccades towards faces in natural scenes, but the visual mechanisms behind this process remain unclear. Here we investigate whether fast saccades towards faces rely on mechanisms that are sensitive to the orientation or contrast of the face image. We present participants pairs of images each containing a face and a car in the left and right visual field or the reverse, and we ask them to saccade to faces or cars as targets in different blocks. We assign participants to one of three image conditions normal images, orientation-inverted images, or contrast-negated images. We report three main results that hold regardless of image conditions. First, reliable saccades towards faces are fast - they can occur at 120-130 ms. Second, fast saccades towards faces are selective - they are more accurate and faster by about 60-70 ms than saccades towards cars. Third, saccades towards faces are reflexive - early saccades in the interval of 120-160 ms tend to go to faces, even when cars are the target. These findings suggest that the speed, selectivity, and reflexivity of saccades towards faces do not depend on the orientation or contrast of the face image. LDC7559 cell line Our results accord with studies suggesting that fast saccades towards faces are mainly driven by low-level image properties, such as amplitude spectrum and spatial frequency.Karst water, with constituting major sources for water supply worldwide, is vulnerable and prone to be polluted. In this study, it is reported that karst water polycylic aromatic hydrocarbons (PAHs) pollution is caused by the infiltration of surface runoff in the bared carbonate areas, which is of universal significance for the protection of groundwater resources in karst region. Hydro-geochemistry, stable isotopes (δD, δ18O and 87Sr/86Sr) and characteristic ratio method were conducted together to illustrate the concentration, distribution, sources and pollution path of polycyclic aromatic hydrocarbons in groundwater in the Liulin karst water system of northern China. The results showed that total concentration of polycyclic aromatic hydrocarbons ranged from 39.25 to 16,830 ng/L in groundwater, with Naphthalene being the dominant component, and the median value increased gradually along the flow path. The highest polycyclic aromatic hydrocarbons concentrations in karst water were mainly observed in the coal mining and the discharge areas. Based on the characteristic ratios, the polycyclic aromatic hydrocarbons in the study area mainly come from local incomplete combustion of woods, fossil fuels, coal and liquid fuels. The slight shift of δD and δ18O and moderate 87Sr/86Sr ratios suggest that the polycyclic aromatic hydrocarbons in karst water is mainly polluted by surface runoff during rain events in the bared karst region. The leakage of river water may partly contribute to the polycyclic aromatic hydrocarbons in some karst water, which normally located close to the karst water - river water mixing line. This study provides a new technical method for tracing the sources and identifying the pollution paths of organic pollution in a karst water system.