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Video game training can effectively improve the cognition of older adults. However, whether video game types and game devices influence the training effects of video games remains controversial. This meta-analysis aimed to access and evaluate the effects of video game types and game devices in video game training on the cognition of older adults. Interestingly, results indicated that mouse/keyboard was superior over other video game devices on perceptual-motor function. The effect size (Hedge's g) for perceptual-motor function decreased by 1.777 and 1.722 when the video game training device changed from mouse/keyboard to driving simulator and motion controller. The effects of cognitive training game and conventional video game were moderated by session length. More well-designed studies are required to clarify the unique efficacy of video game types and devices for older adults with video game training.A fieldwork study conducted in six units of a major metropolitan Australian hospital revealed that nurses' attitudes towards alarms are influenced by each unit's physical layout and caseload. Additionally, nurses relied heavily on both non-actionable and actionable alarms to maintain their awareness of the status of their patients' wellbeing, and used auditory alarms beyond the scope of their intended design. Results suggest that before reducing or removing auditory alarms from the clinical environment to improve patient safety, it is important to understand how nurses in different clinical contexts use current alarm systems to extract meaningful information. Such an understanding could guide appropriate alarm reduction strategies and guide alternative design solutions to support nurses' situation awareness during monitoring.Light/dark cycles play an essential role in people's performance, mood and daily rhythm. This study aimed to evaluate an early prototype of a personalised home lighting system including body-worn loggers. A convenience sample (N = 28) wore the devices for 23 h in the field and were given a demonstration of the lighting system components. Participants reported on questionnaires their acceptance of the lighting system and experience of physical comfort and visual appearance of the body-worn loggers. Semi-structured interviews were also held. In a hierarchical linear regression, physical comfort of the loggers explained 35.8% of the variance of 'the behavioural intention to use the system in the future', and 'performance expectancy' explained 50.6%. The interview data helped understand the reasons for the physical and psychological discomfort of wearing the devices. Many participants reported they were not comfortable about using a mobile phone for presence detection in the home.Damage diagnose imaging methods based on guided waves have been widely developed to depict the position and area of damage in structural health monitoring (SHM). Among them, compact sensor array based imaging methods have been gradually applied with high accuracy, such as phased array imaging, spatial filter imaging, multiple signal classification imaging and so on. However, when the multi-site damage appears nearly, the performance of these methods usually degrades. On one hand, limited to the array aperture, traditional methods cannot distinguish adjacent damage sites. On another hand, some subspace decomposition based methods also fail, suffering from the correlation between scattered array signals from different damage sites. To realize localization of multi-site damage, a novel near-field signal subspace fitting based multi-site damage localization method is proposed in this paper. This method constructs the cost function, which describe the equivalence relation between the signal subspace and array manifold matrix. Then localization of multi-site damage could be realized through multidimensional search for the optimization of cost function. The proposed method is verified on the aluminum panel with 3 damage sites. Experimental results show that the proposed method can realize multi-site damage localization with the angle errors less than 4° and the distance errors less than 35 mm.Pyridaben is a widely used acaricide in agriculture and reaches a high concentration (97 μg/L) in paddy water for a short time when pyridaben was applied to rice. However, its toxicity to aquatic organisms is still poorly understood. Therefore, we assessed the pyridaben cardiotoxicity to aquatic organisms using the zebrafish (Danio rerio) model. We found that pyridaben is highly toxic to aquatic organisms, and LC50 of pyridaben for zebrafish at 72 hpf was 100.6 μg/L. Pyridaben caused severe cardiac malformations and functional abnormalities. Morphologic abnormity included severe pericardial edema, cardiomegaly, decreased cardiomyocytes, thinning of the myocardial layer, linear heart, and increased the distance between sinus venous and bulbus arteriosus (SV-BA). Functional failure included arrhythmia, heart failure, and reduced pumping efficiency. The genes involved in heart development, WNT signaling, BMP signaling, ATPase, and cardiac troponin C were abnormally expressed in the pyridaben treatment group. Exposure to pyridaben increased oxidative stress and induced cell apoptosis. The above causes may lead to cardiac toxicity. The results suggest that pyridaben exposure induced elevated oxidative stress through the WNT signaling pathway, which in turn led to apoptosis in the heart and cardiotoxicity. Besides, pyridaben exposure at the critical stage of cardiac looping (24-36 hpf) resulted in the greatest cardiotoxicity. The chorion reduced the entry of pyridaben and protected zebrafish embryos, resulting in cardiotoxicity second only to the stage of cardiac looping. The study should provide valuable information that pyridaben exposure causes cardiotoxicity in zebrafish embryos and have potential health risks for other aquatic organisms and humans.Geogenic arsenic (As) contamination of groundwater is a health threat to millions of people worldwide, particularly in alluvial regions of South and Southeast Asia. GRL0617 Mitigation measures are often hindered by high heterogeneities in As concentrations, the cause(s) of which are elusive. Here we used a comprehensive suite of stable isotope analyses and hydrogeochemical parameters to shed light on the mechanisms in a typical high-As Holocene aquifer near Hanoi where groundwater is advected to a low-As Pleistocene aquifer. Carbon isotope signatures (δ13C-CH4, δ13C-DOC, δ13C-DIC) provided evidence that fermentation, methanogenesis and methanotrophy are actively contributing to the As heterogeneity. Methanogenesis occurred concurrently where As levels are high (>200 µg/L) and DOC-enriched aquitard pore water infiltrates into the aquifer. Along the flowpath to the Holocene/Pleistocene aquifer transition, methane oxidation causes a strong shift in δ13C-CH4 from -87‰ to +47‰, indicating high reactivity. These findings demonstrate a previously overlooked role of methane cycling and DOC infiltration in high-As aquifers.

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