Dreyergross3794

Using endurance training in nature as a resource in inpatient psychotherapyObjectives Although positive effects of nature on mental health are generally well-documented, clinical studies into the deliberate use of nature as a resource in in-patient psychotherapy are missing. The following study examined whether an endurance training intervention in psychosomatic rehabilitation showed differential effects on patients depending on its implementation in an indoor or outdoor nature setting. Methods Endurance training indoors (ergometer) was compared to training outdoors in the nature (walking) in N = 88 in-patients of a psychosomatic rehabilitation clinic using a linear mixed effects model. Health effects were examined using a standardized questionnaire on somatic symptoms (Giessener Beschwerdebogen GBB-24) and a mood questionnaire (Aktuelle Stimmungsskala ASTS). Seasonal effects were assessed by testing half of the sample in summer and half in winter. Secondary analyses of the linear mixed effects model were run for depression as primary diagnosis which accounted for half of the sample. Results A nature setting positively predicted improvements on the ASTS positive mood scale (B = 0.34; t(245) = 3.25; p = .001; pBonferroni = .052). No significant interaction was found between the effect of the training setting and depression as primary diagnosis (B = -0.05; t(245) = -0.30; p = .76) in secondary analyses. Conclusions The results primarily point to an improvement in mood following endurance training in a nature setting. Improvements are independent of depression as the primary diagnosis.Advanced Parkinson's disease (PD) often brings a set of motor and non-motor features that are particularly challenging to manage. Medication options can be limited by side-effects and quality of life can be severely affected by an accumulating burden of nonmotor symptoms. Here, we reviewed the literature and our clinical experience with the aim of providing a practical approach to the management of advanced PD. We provide guidelines for treatment of physical and neurobehavioral concerns, that occur in advanced PD.Earplugs are a common form of protection for workers exposed to hazardous noise levels. Their comfort directly impacts the effective protection by influencing their consistent and correct use. Nevertheless, comfort definition may vary according to the studies. Thus, a previous review of the literature has shown that to improve our understanding of perceived comfort and to reduce measurement variability, it is advisable to consider comfort through a multidimensional construct (physical, acoustical, functional and psychological). On this basis, the COPROD (COnfort des PROtections auDitives/COmfort of hearing PROtection Devices) questionnaire was developed. It is intended for people working in noisy environments. Nine earplug models were evaluated by 118 participants over a six-week period. This paper presents the successive analyses that were used to validate the structure of the questionnaire and confirm the relevance of the proposed dimensions and of the addressed items. First results suggest a preference for custom moulded earplugs. Practitioner Summary Earplugs comfort conditions the hearing protection of the users. As the definition of comfort can vary between studies, the COPROD questionnaire was developed to jointly evaluate all its dimensions. Nine earplugs models were evaluated by 118 participants during six weeks. This paper presents the validation process of the questionnaire. Abbreviations COPROD COnfort des PROtections auDitives/COmfort of hearing PROtection Devices; HPD hearing protection devices; SEM structural equation modeling; CFA confirmatory factor analysis; GOF goodness of fit; RMSEA root mean square error of approximation; CFI comparison fit index; SRMR standardised root mean square residual.Ireland has had a reliance on voluntary groups to provide peer-to-peer bereavement support. The aim of this study was to explore volunteers', within these voluntary groups, experiences of supporting parents following a fatal fetal anomaly diagnosis. Purposive sampling was used to recruit volunteers (n = 17) and face-to-face interviews undertaken. NVivo12 was utilized to assist in the thematic analysis of the data. Five themes; "motivation for altruistic acts," "being challenged," "value of education and training," "supporting volunteers to support others," and "it is not a sprint, it is a marathon" were identified. Volunteers felt comfortable in their peer-support role but found the lack of knowledge regarding newly implemented termination of pregnancy (TOP) services challenging. The importance of education/training was identified, emphasizing the need for collaboration with health care professionals and other voluntary organizations for support. The findings illustrate the need for collaborative working between health care professionals and volunteers to assist them in supporting bereaved parents.We examined the extent to which a daughter's worries are related to her mother's perceived worries about COVID-19 (i.e., the daughter's perception of her mother's worries). Regard, defined as reciprocity, closeness or compatibility, and responsibility, defined as guilt, burden and protectiveness, were measured as potential moderators of the relationship between the daughter's worries and her mother's perceived worries. A convenience sample of 438 women between the ages of 30 and 60 completed an online survey. We found a significant correlation between daughters' and mothers' perceived COVID-19 worries. This association was moderated by the daughters' regard. For those daughters that characterized their relations as high on regard, higher levels of COVID-19 worries were associated with higher levels of perceived worries among mothers. The importance of considering the relationships between daughters and mothers, during the pandemic is discussed.

Results from the CASPIAN trial (Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer) trial demonstrated the clinical benefit of durvalumab plus etoposide-platinum (EP) chemotherapy as first-line treatment for patients with extensive stage small-cell lung cancer (ES-SCLC). However, considering the high price of durvalumab, it is unclear whether addition of durvalumab to EP chemotherapy has economic value compared with EP alone. In this study, we aimed to evaluate the cost-effectiveness of durvalumab plus EP chemotherapy as a first-line treatment for patients with ES-SCLC.

A Markov model comprising three health states (stable, progressive, and dead) was developed to simulate the process of small-cell lung cancer. Utility and costs were obtained from published resources. SH-4-54 ic50 Health outcomes were derived from the CASPIAN trial. Costs were calculated based on the standard medical fees in Zhejiang Province from Chinese patients' perspective. Utility values were obtained from published data. One-way and probabilistic sensitivity analyses were applied to verify model robustness.

The addition of durvalumab to EP chemotherapy costs more than $32,220, with a gain of 0.14 quality-adjusted life years (QALYs) compared with EP alone. The incremental cost-effective ratio was $230,142.9 per QALY, which exceeds the willingness to pay threshold of $28,527 per QALY. In the sensitivity analysis, the utility values for the progressive state, costs of durvalumab and EP chemotherapy, and costs for the progressive state were considered to be the three most sensitive factors in the model.

The addition of durvalumab to EP chemotherapy is not a cost-effective strategy in the first-line therapy of ES-SCLC from the Chinese payers' perspective.

The addition of durvalumab to EP chemotherapy is not a cost-effective strategy in the first-line therapy of ES-SCLC from the Chinese payers' perspective.

Drug resistance in cancer cells is a major challenge for anti-cancer therapy. Circular RNA (circRNA) circ_0003998 has been identified as an important regulator in the chemoresistance development of non-small cell lung cancer (NSCLC). The purpose of this study was to investigate the molecular basis underlying the resistance control of circ_0003998 in NSCLC.

The levels of circ_0003998, miR-136-5p and coronin 1C (CORO1C) were gauged by the quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Cell viability, colony formation and apoptosis were evaluated by the Cell Counting Kit-8 (CCK-8), colony formation and flow cytometry assays, respectively. Targeted relationships among circ_0003998, miR-136-5p and CORO1C were confirmed by the dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. Animal studies were performed to evaluate the function of circ_0003998

.

Our data indicated that circ_0003998 expression was associated with NSCLC resistance to docetaxel (DTX). The knockdoosis and DTX sensitivity at least partially by controlling CORO1C expression by sponging miR-136-5p, illuminating a rationale for developing circ_0003998 as a therapeutic target of chemoresistant NSCLC.

Induction chemotherapy plus concurrent chemoradiotherapy and concurrent chemoradiotherapy alone are both standard treatment regimens for managing locally advanced nasopharyngeal carcinoma. However, the results of comparisons between them in clinical trials vary. Therefore, we designed this meta-analysis to illustrate their advantages and disadvantages in patients with locally advanced nasopharyngeal carcinoma.

We thoroughly searched the PubMed, EMBASE, and Cochrane Library databases and then merged the effect indicators of hazard ratios and risk ratios using RevMan 5.1.

Seven randomized controlled trials totaling 2,319 patients were included in our research. The synthesized results showed that induction chemotherapy plus concurrent chemoradiotherapy improved overall survival (HR = 0.75, 95% CI 0.63-0.89,

= 0.001), progression-free survival (HR = 0.69, 95% CI 0.60-0.80,

< 0.001), distant metastasis-free survival (HR = 0.65, 95% CI 0.53-0.80,

< 0.001) and locoregional recurrence-free survivcisplatin regimen subgroup, it did not improve remote control or overall survival versus concurrent chemoradiotherapy alone, warranting further clarification.

Induction chemotherapy plus concurrent chemoradiotherapy improved survival outcomes in patients with locally advanced nasopharyngeal carcinoma versus concurrent chemoradiotherapy. For the weekly cisplatin regimen subgroup, it did not improve remote control or overall survival versus concurrent chemoradiotherapy alone, warranting further clarification.In this study, a series of acidic or alkaline polypeptide chains were designed and grafted onto DEG-AM resin using Fmoc solid-phase synthesis to study the relationship between enzyme conformation and carrier surface charge. β-d-glucosidase (βGase) was then immobilized onto these modified carriers by adsorption. Each form of immobilized βGase showed decreasing specific activity compared to that of the free. It could be attributed to both the changes in the enzyme conformation and the decrease in mass transfer efficiency. The optimum temperature of free βGase, DEG@B3-βGase is 55 °C, which of DEG@A3-βGase is 65 °C and they all have the highest activity at pH 5. The Ea values of free βGase, DEG@A3-βGase, and DEG@B3-βGase are 0.546 kJ/mol, 0.224 kJ/mol, and 0.446 kJ/mol, and the Km values were 1.30 mmol/L, 1.44 mmol/L and 2.63 mmol/L, respectively. It shows that free βGase and DEG@A3-βGase are more similar. Meanwhile, the free βGase (1.0 g/L, pH 5.0) stored at 4 °C has a shorter half-life (t1/2), which is only 9 days.