Drachmannweiss0403

The sensitivities for the detection of individual seizures by neonatologists ranged from 18% to 38%. The inter-rater reliability for detection of individual seizure was "fair" (kappa = 0.37; 95% CI 0.32-0.42), infant with seizure was "moderate" (kappa = 0.60; 95% CI 0.44-0.75), duration of individual seizure (ICC 0.22; 95% CI 0.18-0.28) and total duration of seizures in an infant (ICC 0.46; 95% CI 0.30-0.63) was "poor". The neonatologists missed 77-90% of the duration of seizures. CONCLUSION The inter-rater reliability of aEEG for the detection of neonatal seizures was suboptimal. Even when interpreted by experienced and trained clinicians, seizure detection with aEEG has limitations and can miss large number and duration of seizures. Studies utilizing optical coherence tomography (OCT) in psychosis have identified abnormalities in retinal cytoarchitecture. We aim to analyze retinal layer topography in psychosis and its correlation with clinical and imaging parameters. Macular retinal images were obtained via OCT in psychosis probands (n = 25) and healthy controls (HC, n = 15). Clinical, cognitive and structural MRI data were collected from participants. selleck No thinning was noted for the retinal nerve fiber, ganglion cell or inner plexiform layers. We found significant thinning in the right inner temporal, right central, and left inner superior quadrants of the outer nuclear layer (ONL) in probands compared to HC. Thickening of the outer plexiform layer (OPL) was observed in the right inner temporal, left inner superior, and left inner temporal quadrants. The right inner temporal and left inner superior quadrants of both the OPL and ONL showed significant inverse correlations. Retinal pigment epithelium thinning correlated with worse mania symptoms, and thinning in the ONL was associated with worse cognitive function. ONL thinning was also associated with smaller total brain and white matter volume. Our findings suggest that outer retinal layers may provide additional insights into the pathophysiology of psychosis, possibly reflecting synaptic or inflammatory aberrations that lead to retinal pathologies. Understanding processes that lead people to invest a certain amount of time in challenging tasks is important for theory and practice. In particular, researchers often assume strong linear associations between confidence, consensuality (the degree to which an answer is independently given by multiple participants), and response time. The Diminishing Criterion Model (DCM; Ackerman, 2014) is a metacognitive model which explains the stopping rules people employ under uncertainty in terms of the confidence-time association. This model is unique in predicting a curvilinear rather than a linear confidence-time association. Using consensuality as an alternative to confidence for predicting response time offers theoretical and practical opportunities. In four experiments, including replications and variations, we examined confidence (where collected) and consensuality as predictors of the time people invest in three problem-solving tasks and in real-life web searching. The results using consensuality, like those for confidence, fitted the curvilinear time pattern predicted by the DCM, with one exception at least 30% of the population must endorse a potential answer for consensuality to predict response time based on the stopping rules in the DCM. Beyond examining consensuality as a predictor, the study brings converging evidence supporting the DCM's curvilinear confidence-time association over alternative models. The methodology used for analyzing web searching offers new directions for metacognitive research in naturally-performed tasks. BACKGROUND Despite important research advances on the alcohol use behaviors of Latinx immigrants, the bulk of existing evidence has focused on alcohol use patterns after immigrant's arrival to the US. The present study examines pre- to post immigration alcohol use trajectories among Latinx immigrants of diverse national origins throughout their first decade in the United States. METHODS Data for this longitudinal study was collected between 2007 and 2017. At baseline, retrospective pre-immigration alcohol use data was collected on 527 Cuban, South American and Central American participants ages 18-34 who immigrated to the US less than one year prior. Three subsequent follow-up assessments over the past 10 years have collected data on post-immigration alcohol use. RESULTS Overall decreases in pre- to post-immigration alcohol use were found. Gender, income, and national origin were associated with distinct drinking patterns after immigration. CONCLUSION Findings underscore the importance of examining pre-immigration experiences among Latinx immigrants, in addition to longitudinal alcohol use patterns after immigration. This knowledge is important not only from an epidemiological perspective, but for the development of effective culturally relevant alcohol interventions targeting Latinx immigrants early in the immigration process. OBJECTIVE Globally, the prevalence of hazardous drinking peaks in young adulthood, and there is mixed evidence on whether internalising symptoms and executive functioning deficits are associated with this increased risk. This study tested whether internalising symptoms in interaction with executive functioning deficits are associated with high alcohol use disorder symptoms in emerging adulthood, via drinking motives to cope with negative affect and alcohol consumption. METHOD An Australian sample of 155 young adults aged 17 to 24 years (M = 20.97, SD = 2.40) provided self-report data on internalising symptom severity and alcohol-related outcomes (n = 155), and neuropsychological data measuring executive functioning (n = 104). Confirmatory factor analyses were conducted to identify two latent variables representing internalising symptoms and executive functions. A series of latent moderated structural equation models and a latent mediated moderation structural equation model examined the inter-relations between internalising symptoms, executive functions and alcohol measures. RESULTS High levels of internalising symptoms in interaction with executive functioning deficits were associated with strong drinking motives to cope with negative affect, high past month alcohol consumption and greater alcohol use disorder symptoms. Drinking motives to cope with negative affect and alcohol consumption mediated the relationship between the internalising symptoms and executive functioning latent interaction term with alcohol use disorder symptoms. CONCLUSIONS This research highlights greater executive functioning resources are associated with low desires to drink hazardous amounts of alcohol as a maladaptive way to cope with negative feelings among young people. It therefore may be useful to target executive functioning ability alongside internalising symptomology in alcohol prevention and intervention initiatives.