Douglaslamont4443

ong immunocompromised children may be a protective factor against a severe COVID-19.

To evaluate the outcomes of a 6-month follow-up after switching to brolucizumab from aflibercept to treat neovascular age-related macular degeneration (AMD) in Japanese patients.

Retrospective observational study.

We studied 45 consecutive eyes of 42 patients diagnosed with neovascular AMD, who were switched to intravitreal brolucizumab injection (IVBr) after receiving intravitreal aflibercept injection (IVA) using a treat-and-extend (TAE) regimen. Patients who had brolucizumab-associated intraocular inflammation (IOI) were excluded from the study. The mean changes in the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), central foveal thickness (CFT), central choroidal thickness (CCT), and treatment intervals were evaluated at 6 months after the switch to IVBr.

One eye of 1 patient was excluded because of IOI after the switch; 44 eyes of 41 patients were enrolled in this study. The mean logMAR BCVA was maintained throughout the follow-up period when compared with the baseline value (P > .05 at 6 months). However, the mean CFT and CCT at 6 months had decreased significantly (P < .05 and P < .001, respectively). The mean treatment interval was extended from 5.75 to 8.12 weeks.

Switching to brolucizumab from aflibercept using a TAE regimen might be effective for maintaining functional outcomes and extending intervals in Japanese patients with AMD.

Switching to brolucizumab from aflibercept using a TAE regimen might be effective for maintaining functional outcomes and extending intervals in Japanese patients with AMD.According to the "fetal origin of disease" hypothesis, air pollution exposure in pregnancy may play an important role in stimulating the early programming of asthma and allergies. However, previous studies reported inconsistent findings. The aim of this meta-analysis was to provide higher grade evidence and quantitatively analyze the link between prenatal exposure to outdoor air pollutants and childhood asthma and wheezing. Databases (Web of Science and PubMed) were extensively searched for articles published from the start of the database to September 15, 2021. Either random-effect model or fixed-effect model was used to estimate the disease-specific relative risks (RR) with the corresponding 95% confidence intervals (CIs) to estimate the association. Newcastle-Ottawa Quality Score (NOS) was used to assess the quality of studies. This study finally included 13 cohort studies, and the findings showed that NO2 and SO2 exposure during entire pregnancy was significantly associated with wheezing (RR = 1.032, 95% CI 1.000, 1.066) and asthma (RR = 1.114, 95% CI 1.066, 1.164), respectively. Further analyses showed that PM2.5 were positively associated with asthma in the second (RR = 1.194, 95% CI 1.143, 1.247) and third trimester (RR = 1.050, 95% CI 1.007, 1.094), while NO2 (RR = 1.060, 95% CI 1.021, 1.101) and SO2 (RR = 1.067, 95% CI 1.013, 1.123) were shown positively associated with asthma only in the second trimester. The relationship between wheezing and outdoor air pollutants was not significant in any of the pregnancy subgroups. This study suggests that prenatal exposure of outdoor air pollution may increase the asthma and wheezing risk in the offspring and that the second trimester may be a sensitive period for air pollution exposure. But the interpretation of the causal association is hampered by limited number of studies on dose response.The global records of infectious diseases, including Western and Eastern documents from 1825 to 2020, during which sunspot observations are considered reliable, show that 27 of the 34 pandemic outbreaks were coincident with sunspot number maxima or minima. There is evidence that the intensity of galactic cosmic rays is anti-correlated with solar activity and that cloud seed formation is accelerated by galactic cosmic rays. There are a substantial number of research papers showing the relationship between COVID-19 and vitamin D deficiency. The data analysis of ozone thickness measured based on NASA satellite observations revealed that ozone thickness has 11-year and 28-month cycles. Because the 11-year cycles of ozone thickness and cloud seed attenuation are anti-correlated, when either one becomes extremely thick, such as at the maximum or minimum point of solar activity, UV radiation is over-attenuated, and human vitamin D deficiency is globally increased. This finding explains the coincidence of pandemic outbreaks with the extrema of the sunspot numbers. Vitamin D supplementation can be an effective countermeasure against the spread of infectious diseases, which is a paramount importance to global society. Future pandemic forecasting should include the 11-year and 28-month cycles of UV radiation. This founding completes the relationship between solar activity and human health through the earth's environment.Sulfidated nanoscale zerovalent iron (S-nZVI) supported on a flower spherical Mg(OH)2 with different Mg/Fe ration were successfully synthesized. The synthesized materials were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), Brunauer-Emmett-Teller (BET), and X-ray photoelectron spectroscopy (XPS). The results showed that S-nZVI particles were well dispersed on the petals of the flower spherical Mg(OH)2. The influence of factors, including the initial solution pH, Mg/Fe, S/Fe were studied. The trichloroethylene (TCE) adsorption data on Mg(OH)2 and S-nZVI @Mg(OH)2 fit well to a Langmuir isotherm model, and the maximum adsorption of S-nZVI @Mg(OH)2 was 253.55 mg/g, which was 2.6-fold of S-nZVI. Meanwhile, the S-nZVI @Mg(OH)2 composite expanded the pH selection range of S-nZVI from 2 to 11. Cycling experiments showed that removal rate was 58.3% for the 5th cycle. TCE removal was due to synergistic action of reduction coupled with adsorption. During this process, 65.43% of total remove TCE from ion chromatography data was reduced and 34.57% of total remove TCE was adsorbed finally. At the same time, adsorption favors reduction. These observations indicated that the S-nZVI @Mg(OH)2 can be considered as potential adsorbents to remove TCE for environment remediation.Imidazolium sulfonic acid chloride grafted ZrO2 nanoparticles (ZrO2-IL) were synthesized through facile post-treatment of the nanoparticles with the imidazolium-sulfonic acid chloride ionic liquid. The immobilization of the ionic liquid over the ZrO2 nanoparticles was evident from the XRD, SEM, TEM, Raman, BET, and XPS analysis. The results obtained from the XRD analysis clearly show that the catalyst has an orthorhombic structure and from the BET analysis it is evident that the surface is mesoporous with uniform pore sizes and pore distribution. Further evidence of immobilization of ionic liquid over the ZrO2 NPs was obtained from the SEM, TEM, XPS, and Raman analysis. Under mild conditions, the synthesized heterostructure was used in the acid-catalyzed esterification of different acids. The ZrO2-IL catalyst converts 99% of the acid to ester with a 98.9% yield in 1h. The material was also shown to be highly efficient as catalyst for the Biginelli reaction under solvent-free conditions, with the catalyst for dihydropyrimidin-2(1H)-one (DHPMs) in 1h with 99.2% conversion and 99% yield. The synergy between the ionic liquid catalyst and the substrates increased the catalytic efficiency and resulted in high-yield product conversion. The mechanism of both transformation reactions was investigated, as well as the synergy between ionic liquid and ZrO2 nanoparticles for better catalytic efficiency was established.The problem of heavy metal pollution in the environment is of increasing concern, especially in the agricultural environment. In this study, a method of element identification and pollution degree monitoring of Cu and Pb pollution in corn was proposed by using variational mode decomposition (VMD) and bispectrum estimation. The results showed that the u3 component of VMD shows sensitivity to corn heavy metal monitoring. The bispectrum graphs of healthy corn leaves, Cu polluted, and Pb polluted were significantly different; these differences could quickly distinguish whether corn was polluted by heavy metals and the categories of pollution elements. The pollution prediction models constructed by the combination of the normalized frequency (fm) and the energy entropy (Wee) were proven to have a high fitting degree and application accuracy after verification, which can effectively monitor the pollution of Cu and Pb in corn. It provides a basis for the monitoring of pollution in the agricultural environment and the formulation of targeted control plans.This paper examines the impact of climate variables and financial development on agricultural value-added and cereal production in selected Southeast Asian economies from 1970 to 2016. Rabusertib The current research applies second-generation advanced techniques to accomplish robust and reliable outcomes. The findings from the FM-OLS estimation disclose that climatic factors, for instance, CO2e and average temperature, impact both agricultural value-added and cereal production negatively, and financial development has an inverted U-shaped influence on both agricultural value-added and cereal production. Meanwhile, other important factors, including cropped area, income level, and rural labor force, significantly improve agricultural value-added and cereal production. Furthermore, the FM-OLS estimator's D-H panel causality test outcomes are reliable. The findings of our study reveal that both the short- and long-run risks of climatic changes to the agricultural sector pose a large-scale threat to food security in Southeast Asian economies. As a result, a robust and stable financial development in terms of governance of climate change finance in the agriculture sector must be achieved to enhance farmers' ability to adapt to current and future climate change adverse impacts.This study intends to examine the effect of CEO succession with gender change from male to female (i.e., female CEO succession) on corporate social responsibility (CSR) reporting. Based on insights from upper echelons theory, it is proposed that female CEO successors are more likely than male CEO successors to improve the firm's CSR reporting level due to variations in their traits, values, and preferences regarding green issues, especially CSR. The study also explores the influence of the firm's ownership status (i.e., SOEs vs. non-SOEs) and performance (high-performance firms vs. low-performance firms) on the relationship between female CEO succession and CSR reporting. Using data from Chinese publicly traded firms from 2010 to 2020, this study employs the logistic regression technique to examine the proposed relationship between female CEO succession and CSR reporting and presents robust evidence that female CEO succession has a positive effect on firm CSR reporting, and that this effect is more prevalent in non-SOEs and high-performance firms than in SOEs and low-performance firms, respectively. The study adds fresh insights to the extant literature on CSR and corporate leadership and offers useful policy recommendations for corporate decision-makers and policymakers while considering women's involvement in succession plans for top leadership positions like CEO to tackle the strategic management of CSR disclosure in China.