Donnellymarshall3958

Plasmonic gold nanoparticles have been widely used for localized surface plasmon resonance (LSPR) sensing. Herein, we investigate the enhanced sensitivity for the detection of the chemisorption of pyridine and biotinylated bovine serum albumin (BSA) proteins, which are important molecules widely used in biological studies, at the inflection points (IFs) of the LSPR scattering spectra of single gold nanorods (AuNRs). The results showed that the homogeneous LSPR IFs located at the long wavelength side (or low energy side) of the LSPR scattering peak exhibited the highest sensitivity for the detection of chemical adsorption with respect to the counterpart LSPR peak maxima. The increased sensitivity can be attributed to the shape change of the LSPR peak when the local refractive index is increased by chemisorption. Furthermore, real-time monitoring of molecular binding events on single AuNRs was performed after introducing pyridine in water, and an improved efficiency of the sensors was observed at the LSPR IFs to detect target molecules in single AuNRs. Therefore, we present the significance of tracking curvature shapes through homogeneous LSPR IFs close to the resonance energy upon chemical adsorption of pyridine and BSA-biotin, rather than tracking their counterpart LSPR maximum peak shifts, for AuNRs.Mechanical energy harvesters are widely studied because of their diverse applications, such as harvesting ocean wave energy, self-powered wireless sensors, portable power supplies and so on. To be feasible, an energy harvester needs to provide a high output current and voltage, in addition to being environmentally friendly. Hence, in this study, a new energy harvester is developed via reversible deformation of a three-dimensional graphene aerogel which was immersed in a salt solution. The movement of solvated ions in the diffusion layer during the squeezing of the electrode induced the transmission of electrons out of graphene, resulting in electrical energy. The developed harvester can supply a power density of 11.7 W kg-1 and an energy density of 14.3 J kg-1, in addition to achieving a high energy conversion efficiency of approximately 43.2%. The device can also generate a high open-circuit voltage and short-circuit current when an external compression strain is applied. Moreover, it can be easily scaled up by being connected in series with multiple harvesters. Thus, the proposed energy harvester can not only be widely used for harvesting ocean wave energy, but also for adsorbing pollutants to prevent the pollution of ocean environments.In this paper, one-step hydrothermal and electrodeposition methods were used to prepare a MoS2 quantum dot (QD) solid-phase electrochemiluminescent (ECL) electrode for the detection of melamine residues in milk powder. With the assistance of chitosan, MoS2 QDs fixed by the one-step electrodeposition method show better ECL performance than those by traditional deposition methods due to better dispersibility and stability. Based on the quenching of the MoS2 QDs ECL signal by melamine, quantitative detection of melamine in the sample was performed. The structure and morphology of a MoS2-CHIT/indium tin oxide (ITO) solid-phase ECL electrode were characterized by TEM and XPS, and melamine was detected by the ECL method using a three-electrode system. The proposed sensor exhibited good linearity in the range of 1.00 × 10-11 to 1.00 × 10-7 mol L-1 (ΔI = 12 100.62 + 1009.93 lg c (mol L-1), R2 = 0.997), and the method shows the advantages of simplicity and sensitivity compared to traditional detection methods. The interference of common ions in milk powder on the modified electrode was within 5%, and the recovery rate of real sample detection was within 97-98%. As a result, the proposed method is suitable for detecting melamine residues in milk powder.In this study, based on silica hollow sphere photonic crystals (SHSPCs), a simple and selective fluorescence sensor for high-performance diethylamine detection was developed. The sensor does not involve complicated integration of arrays or tedious synthetic work. During the detection, the SHSPCs could significantly enhance the fluorescence intensity of rhodamine 6G (Rh6G), and meanwhile, adsorb some Rh6G on their surface. Due to the competitive adsorption, diethylamine could free the Rh6G which was adsorbed on the surface of the SHSPCs, thus enhancing the fluorescence emission intensity with the increase of Rh6G concentration. The second enhancement of the fluorescence emission enabled the selective detection of diethylamine. It is remarkable that a simple and readily available dye (Rh6G) facilitates the efficient detection of diethylamine. Moreover, the sensor has good interference immunity, stability and reusability.Micro-transfer printing is an effective method that enables the integration of micro-scale heterogeneous materials for flexible electronics. As the key component of micro-transfer printing equipment, the stamp is adopted to pick up and print microdevices due to its reversible and controllable adhesion. In this paper, we propose a novel microstructured stamp based on the bionic theory, which consists of a microchamber and four microchannels. A theoretical model about the pressure change of the gas in the microchamber is established and the effects of compression distance and pull-up velocity on the pull-off force of the stamp are investigated. The performance test results show that the pull-off force of the stamp can be controlled by both the compression distance and the pull-up velocity. Finally, micro-transfer printing operations of microdevices with different sizes, shapes and materials are realized based on the proposed microstructured stamp. The results show that the proposed microstructured stamp exhibits good performance in the transfer printing of microdevices, and provides a new way for the design of microstructured stamps for micro-transfer printing without an extra excitation system.A highly sensitive ELISA is critical for early diagnosis and biomarker discovery of various diseases. Although various ELISA technologies have been developed with high sensitivity, they are limited by poor repeatability, high cost, the dependence on complex equipment and/or a prolonged reaction time. 5Azacytidine To this end, we developed a fast and ultrasensitive ELISA (termed RELISA) based on rolling circle amplification (RCA) and enzymatic signal amplification. The RELISA is established on the traditional ELISA, with only one more RCA step that can be accomplished within 10 minutes. The prolonged single strand DNA (ssDNA) from RCA is able to enrich abundant horseradish peroxidase conjugate (HRP) modified detection probes. Consequently, the intensive HRP is able to catalyze TMB-H2O2 to produce significantly enhanced colorimetric signals. With CEACAM-7 as a model biomarker, the RELISA achieves the limit of detection as low as 2.82 pg mL-1, which is ∼50 times higher than that of the traditional ELISA. Therefore, we envision that the developed RELISA would be a powerful tool for the early diagnosis of various major diseases.In recent years, the transgender community has received an unprecedented amount of attention from both the media and the scientific community. The increase in referrals to clinics specializing in therapies aimed at affirming transgender people's identity, the spread of these clinics around the world, the increased awareness by transgender people of the different therapeutic options and procedures available, the depathologization by the psychiatric world of this gender identity and the greater presence of transgender people in the media are just some factors that have contributed to an increased awareness of this complex reality. In this article, after providing a definition of some key concepts for understanding the complexity of the transgender world, the authors will describe the debate that exists in the scientific community and in the transgender world itself regarding the controversial diagnosis of gender dysphoria. Several possible transition paths that arise from this debate and consequent alignment with the different and contradictory conclusions that followed will be presented. In particular, a possible transition path will be presented based on the medical-psychiatric model closely related to the diagnosis of gender dysphoria (Italian model) and a model that is developing in some parts of the United States based on informed consent and the non-need for diagnosis of gender dysphoria in order to access the transition path.Colonial psychiatry represented the first, despite distorted, attempt to interpret psychiatric symptoms in non-Western cultures. This psychiatry, therefore, laid the roots for the subsequent development of ethnopsychiatry, but it also represented the first example of the political use of this discipline. Purpose of the present article is to provide a critical review about the management of psychiatric disorders in the different colonial empires. We critically summarized relevant literature about theory and practice of colonial psychiatry in the different European empires. All the colonial empires were characterized by few resources destined to mental health both for the colonizers, but especially for the local populations. The British used reports from psychiatric hospitals to maintain political control over the colonies. French colonial psychiatry focused more on cultural assimilation, while the Dutch one was based on theories of racial inferiority of local populations. In Italy, colonial psychiatry focused more on the differences between the north and south of the country than on non-European territories. Although with differences between the various empires, colonial psychiatry provided means and support for the political and social control of the occupied territories.

The purpose of this article is to assess the impact of comorbid depression on the outcome of elderly patients diagnosed with chronic heart failure (CHF).

We conducted a prospective analysis of the outcomes of 251 patients, hospitalized throughout 2019 for an exacerbation of CHF. The sample was divided into two groups group A - 153 patients with major depressive disorder (MDD); group B - 98 patients without clinical depression. We analyzed the associations between socioeconomic status (SES) and the severity of depressive symptoms, pharmacotherapy, readmission, and mortality rates within 30 days and at one year. We classified patients' SES according to residence, income, education level, and family support. Quality of Life (QL) total scores were also assessed. The severity of mental health complaints was evaluated using the Montgomery-Asberg Depression Ratings (MADRS) scale; individual somatic evaluation included the analysis of the alteration of the left ventricular ejection fraction (LVEF), as well as detents with CHF, and is associated with a reduced LVEF and QL. Our results showed that, despite a similar therapeutic regimen, patients with comorbid MDD required more frequent, prolonged admissions and higher one-year mortality rates than those without MDD.

In eating disorders, the association with other psychiatric symptoms is of particular interest. The association between anorexia nervosa and psychotic symptoms is less studied than that with affective disorders (anxiety/depression). The aim of this study is to describe a psychotic symptom (paranoia) in adolescents with anorexia nervosa looking at several potential explicative associated factors eating disorder symptoms, body image concerns, depression and social anxiety. Our hypothesis is that paranoia in anorexia nervosa patients is better explained by the concomitant depression and social anxiety symptoms than the core symptoms of the disease (eating disorder symptoms or body image concerns).

This is a retrospective study. Consecutive, help-seeking adolescents, admitted to the Eating Disorder Service of the Integrated Pediatric Care Department, Luigi Vanvitelli University Hospital, constituted the sample. Data was obtained through retrospective collection of clinical interviews and self-report questionnaires, used for the routine assessment of these patients, administered by trained and expert child and adolescent psychiatrists, they were the Eating Attitude Test-26 (EAT-26), the Body Uneasiness Test-A (BUT-A), the Children Depression Inventory (CDI), the Liebowitz Social Anxiety Scale-Children and Adolescents (LSAS-CA) and the paranoia subscale of the Specific Psychotic Experiences Questionnaire (SPEQ).