Doganfaircloth0326

Moreover, a Progressive Negative Sample Selection mechanism (PNSS) is designed to mine more suitable negative samples for training, which can effectively promote detailed discrimination ability in the generative model and facilitate the generation of more fine-grained results. Extensive experiments on Oxford-102 and CUB datasets reveal that our MA-GAN significantly outperforms the state-of-the-art methods.Multipath and off-axis scattering are two of the primary mechanisms for ultrasound image degradation. Inflammation inhibitor To address their impact, we have proposed Aperture Domain Model Image REconstruction (ADMIRE). This algorithm utilizes a model-based approach in order to identify and suppress sources of acoustic clutter. The ability of ADMIRE to suppress clutter and improve image quality has been demonstrated in previous works, but its use for real-time imaging has been infeasible due to its significant computational requirements. However, in recent years, the use of graphics processing units (GPUs) for general-purpose computing has enabled the significant acceleration of compute-intensive algorithms. This is because many modern GPUs have thousands of computational cores that can be utilized to perform massively parallel processing. Therefore, in this work, we have developed a GPU-based implementation of ADMIRE. The implementation on a single GPU provides a speedup of two orders of magnitude when compared to a serial CPU implementation, and additional speedup is achieved when the computations are distributed across two GPUs. In addition, we demonstrate the feasibility of the GPU implementation to be used for real-time imaging by interfacing it with a Verasonics Vantage 128 ultrasound research system. Moreover, we show that other beamforming techniques, such as delay-and-sum (DAS) and short-lag spatial coherence (SLSC), can be computed and simultaneously displayed with ADMIRE. The frame rate depends upon various parameters, and this is exhibited in the multiple imaging cases that are presented. An open-source code repository containing CPU and GPU implementations of ADMIRE is also provided.We propose to learn a probabilistic motion model from a sequence of images for spatio-temporal registration. Our model encodes motion in a low-dimensional probabilistic space - the motion matrix - which enables various motion analysis tasks such as simulation and interpolation of realistic motion patterns allowing for faster data acquisition and data augmentation. More precisely, the motion matrix allows to transport the recovered motion from one subject to another simulating for example a pathological motion in a healthy subject without the need for inter-subject registration. The method is based on a conditional latent variable model that is trained using amortized variational inference. This unsupervised generative model follows a novel multivariate Gaussian process prior and is applied within a temporal convolutional network which leads to a diffeomorphic motion model. Temporal consistency and generalizability is further improved by applying a temporal dropout training scheme. Applied to cardiac cine-MRI sequences, we show improved registration accuracy and spatio-temporally smoother deformations compared to three state-of-the-art registration algorithms. Besides, we demonstrate the model's applicability for motion analysis, simulation and super-resolution by an improved motion reconstruction from sequences with missing frames compared to linear and cubic interpolation.Recently, ultra-widefield (UWF) 200° fundus imaging by Optos cameras has gradually been introduced because of its broader insights for detecting more information on the fundus than regular 30° - 60° fundus cameras. Compared with UWF fundus images, regular fundus images contain a large amount of high-quality and well-annotated data. Due to the domain gap, models trained by regular fundus images to recognize UWF fundus images perform poorly. Hence, given that annotating medical data is labor intensive and time consuming, in this paper, we explore how to leverage regular fundus images to improve the limited UWF fundus data and annotations for more efficient training. We propose the use of a modified cycle generative adversarial network (CycleGAN) model to bridge the gap between regular and UWF fundus and generate additional UWF fundus images for training. A consistency regularization term is proposed in the loss of the GAN to improve and regulate the quality of the generated data. Our method does not require that images from the two domains be paired or even that the semantic labels be the same, which provides great convenience for data collection. Furthermore, we show that our method is robust to noise and errors introduced by the generated unlabeled data with the pseudo-labeling technique. We evaluated the effectiveness of our methods on several common fundus diseases and tasks, such as diabetic retinopathy (DR) classification, lesion detection and tessellated fundus segmentation. The experimental results demonstrate that our proposed method simultaneously achieves superior generalizability of the learned representations and performance improvements in multiple tasks.

In biomanufacturing there is a need for quantitative methods to map cell viability and density inside 3D bioreactors to assess health and proliferation over time. Recently, noninvasive MRI readouts of cell density have been achieved. However, the ratio of live to dead cells was not varied. Herein we present an approach for measuring the viability of cells embedded in a hydrogel independently from cell density to map cell number and health.

Independent quantification of cell viability and density was achieved by calibrating the 1H magnetization transfer- (MT) and diffusion-weighted NMR signals to samples of known cell density and viability using a multivariate approach. Maps of cell viability and density were generated by weighting NMR images by these parameters post-calibration.

Using this method, the limits of detection (LODs) of total cell density and viable cell density were found to be 3.88x10^8 cells mL^-1 Hz^-1/2 and 2.36x10^9 viable cells mL^-1 Hz^-1/2 respectively.

This mapping technique provides a noninvasive means of visualizing cell viability and number density within optically opaque bioreactors.