Dillardrohde5614

The ability of marine organisms to thrive over wide ranges of environmental stressors that perturb structures of proteins, nucleic acids, and lipids illustrates the effectiveness of adaptation at the biochemical level. A critical role of these adaptations is to achieve a proper balance between structural rigidity, which is necessary for maintaining three-dimensional conformation, and flexibility, which is required to allow changes in conformation during function. The Goldilocks principle refers to this balancing act, wherein structural stability and functional properties are poised at values that are just right for the environment the organism faces. Achieving this balance involves changes in macromolecular sequence and adaptive change in the composition of the aqueous or lipid milieu in which macromolecules function. This article traces the development of the field of biochemical adaptation throughout my career and shows how comparative studies of marine animals from diverse habitats have shed light on fundamental properties of life common to all organisms. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Argo, an international, global observational array of nearly 4,000 autonomous robotic profiling floats, each measuring ocean temperature and salinity from 0 to 2,000 m on nominal 10-day cycles, has revolutionized physical oceanography. Argo started at the turn of the millennium, growing out of advances in float technology over the previous several decades. After two decades, with well over 2 million profiles made publicly available in real time, Argo data have underpinned more than 4,000 scientific publications and improved countless nowcasts, forecasts, and projections. We review a small subset of those accomplishments, such as elucidating remarkable zonal jets spanning the deep tropical Pacific; increasing understanding of ocean eddies and the roles of mixing in shaping water masses and circulation; illuminating interannual to decadal ocean variability; quantifying, in concert with satellite data, contributions of ocean warming and ice melting to sea level rise; improving coupled numerical weather predictions; and underpinning decadal climate forecasts. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Regulation of stress responsive genes represents one of the best examples of gene induction and the relevance and involvement of different regulators may change for a given gene depending on the challenging stimulus. HSP12 gene is induced by very different stimuli, however the molecular response to the stress has been characterized in detail only for heat shock treatments. In this work we want to verify whether, the regulation of transcription induced by oxidative stress, utilizes the same epigenetic solutions relative to those employed in heat shock response. We also monitored HSP12 induction employing spermidine, a known acetyltransferase inhibitor, and observed an oxidative stress that synergizes with spermidine treatment. Our data show that during transcriptional response to H2O2, histone acetylation and chromatin remodeling occur. However, when the relevance of Gcn5p on these processes was studied, we observed that induction of transcription is GCN5 dependent and this does not rely on histone acetylation by Gcn5p despite its HAT activity. Chromatin remodeling accompanying gene activation is rather GCN5 dependent. Thus, GCN5 controls HSP12 transcription after H2O2 treatment by allowing chromatin remodeling and it is only partially involved in HSP12 histone acetylation regardless its HAT activity.Evaluation of nuclear magnetic relaxation dispersion (NMRD) curves obtained by the fast field cycling nuclear magnetic resonance (FFC-NMR) relaxometry technique is a valuable tool for analyzing the microscopic dynamics of condensed matter systems. However, quantitative data analysis involves several conceptual and practical issues. Moving forward from previous literature approaches, we propose a new analysis method, relying on the elaboration of the inverse integral transform of the NMRD curve. Our approach results in a true heuristic method, able to unambiguously individuate the dynamic domains in the system, thereby avoiding the possible introduction of any element of discretion. The analysis of some data sets relevant to real samples suggests the possibility that the results obtained with the heuristic method may be actually led back to some distinct physical/chemical features of the systems.Rechargeable lithium-oxygen batteries (LOBs) have attracted increasing attention due to their high energy density but highly rely on the development of efficient oxygen catalysts for reversible Li2O2 deposition/decomposition. Herein, highly porous carbon nanocubes with a specific surface area up to 1600 m2 g-1 are synthesized and utilized to tightly anchor Ru nanoparticles for using as the oxygen-cathode catalyst in LOBs, achieving a low charge/discharge potential gap of only 0.75 V, a high total discharge capacity of 17,632 mA h g-1, and a superb cycling performance of 550 cycles at 1000 mA g-1. Comprehensive ex situ and operando characterizations unravel that the outstanding LOB performance is ascribed to the highly porous catalyst structure embedding rich active sites that synergistically function in reducing overpotentials, suppressing parasitic reactions, accommodating reaction products, and promoting mass and charge transportation.The classical AlCl3/imidazole-chloride-salt ionic liquid electrolytes are expensive, corrosive, and environmentally sensitive, which limit the large-scale application of aluminum-ion batteries. Herein, a gel polymer electrolyte is prepared through a facile process using a low-cost AlCl3/Et3NHCl ionic liquid as the plasticizer and polyamide as the polymer matrix. The gel polymer electrolyte achieves a decent ionic conductivity of 3.86 × 10-3 S cm-1, a wide electrochemical stability window of 2.6 V (vs Al), and long-term interfacial stability at room temperature. The assembled Al//graphite battery delivers considerable rate capability and excellent cycling performance. check details Besides, the gel polymer electrolyte can alleviate both moisture sensitivity and leakage corrosion issues owing to the full encapsulation of the ionic liquid by polyamide polymeric matrix. The gel polymer electrolyte should offer great potential for aluminum-ion battery applications.