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The Republic of Azerbaijan suffers from low agricultural productivity caused by soil salinization and erosion, and limited and insufficient soil data are available for economic and political reasons. In this study, soil salinity and heavy metal levels were assessed. Environmental risk assessment was conducted to evaluate the potential risk posed by soils to human health. Soil guideline values were proposed to monitor soil pollution in the Republic of Azerbaijan. Water extraction and spatial variability analysis were conducted to understand soil salinization and heavy metal pollution. Among the 20 studied elements, the elements Ca, Cl, and S and the heavy metals Cr, Ni, and Pb were classified as problematic on the basis of the geoaccumulation index, and As was also identified as posing a possible risk on the basis of the potential ecological risk index. Based on the developed soil guideline values for agricultural soil, the As, Cr, and Ni in the soil samples exceeded their respective guidelines by 31.3, 41.8, and 61.6%, respectively. Water extraction results confirmed that 99% of the leached ions were cationic salts, and the most problematic ion was Na, followed by Ca, Cl, and S. The extractability values of Cr and Ni were significantly lower than those of other heavy metals, which implies that their actual leaching potential may be overestimated. The linear regression and spatial variability analysis confirmed that leachable salts have accumulated in lowland areas due to the capillary rise of water and evaporation, but the distribution of heavy metals confirmed that As, Cr, and Ni were abundant in agricultural soils. Our results clearly showed that heavy metal soil contamination and high salinity levels are major problems that should be considered when assessing food safety and health hazards in the Mugan Plain of Azerbaijan. Therefore, future studies should be performed for additional environmental risk assessment, detailed hazard identification, and health risk assessment.

Given the severe economic and performance implications of hamstring injuries, there are different attempts to identify their risk factors for subsequently developing injury prevention strategies to reduce the risk of these injuries. One of the strategies reported in the scientific literature is the application of interventions with eccentric exercises. To verify the effectiveness of these interventions, different eccentric strength measurements have been used with low-cost devices as alternatives to the widespread used isokinetic dynamometers and the technically limited handheld dynamometers. Pentylenetetrazol datasheet Therefore, the purpose of the present systematic review was to summarize the findings of the scientific literature related to the evaluation of eccentric strength of hamstring muscles with these new technologies.

Systematic searches through the PubMed, Scopus, and Web of Science databases, from inception up to April 2020, were conducted for peer reviewed articles written in English, reporting eccentric strength of haes assessed by different devices may be recommended for monitoring the neuromuscular status of athletes.

The current evidence is insufficient to recommend a practical guide for sports professionals to use these new technologies in their daily routine, due to the need for standardized definitions and calculations. Furthermore, more studies with female athletes are warranted. Despite these limitations, the eccentric strength of hamstring muscles assessed by different devices may be recommended for monitoring the neuromuscular status of athletes.A homogeneous fluorescence quenching immunoassay is described for simultaneous separation and detection of aflatoxin M1 (AFM1) in milk. The novel assay relies on monoclonal antibody (mAb) functionalized Fe3O4 decorated reduced-graphene oxide (rGO-Fe3O4-mAb) as both capture probe and energy acceptor, combined with tetramethylrhodamine cadaverine-labeled aflatoxin B1 (AFB1-TRCA) as the energy donor. In the assay, AFB1-TRCA binds to rGO-Fe3O4-mAb in the absence of AFM1, quenching the fluorescence of TRCA by resonance energy transfer. Significantly, the immunoassay integrates sample preparation and detection into a single step, by using magnetic graphene composites to avoid washing and centrifugation steps, and the assay can be completed within 10 min. Under optimized conditions, the visual and quantitative detection limits of the assay for AFM1 were 50 and 3.8 ng L-1, respectively, which were significantly lower than those obtained by fluorescence polarization immunoassay using the same immunoreagents. Owing to its operation and highly sensitivity, the proposed assay provides a powerful tool for the detection of AFM1.Oxidative DNA damage plays an important role in the pathogenesis of various diseases. Among oxidative DNA lesions, 8-oxoguanine (8-oxoG) and its corresponding nucleotide 8-oxo-2'-deoxyguanosine (8-oxodG), the guanine and deoxyguanosine oxidation products, have gained much attention, being considered biomarkers for oxidative DNA damage. Both 8-oxoG and 8-oxodG are used to predict overall body oxidative stress levels, to estimate the risk, to detect, and to make prognosis related to treatment of cancer, degenerative, and other age-related diseases. link2 The need for rapid, easy, and low-cost detection and quantification of 8-oxoG and 8-oxodG biomarkers of oxidative DNA damage in complex samples, urine, blood, and tissue, caused an increasing interest on electrochemical sensors based on modified electrodes, due to their high sensitivity and selectivity, low-cost, and easy miniaturization and automation. This review aims to provide a comprehensive and exhaustive overview of the fundamental principles concerning the electrochemical determination of the biomarkers 8-oxoG and 8-oxodG using nanostructured materials (NsM), such as carbon nanotubes, carbon nanofibers, graphene-related materials, gold nanomaterials, metal nanoparticles, polymers, nanocomposites, dendrimers, antibodies and aptamers, and modified electrochemical sensors.

Re-entry devices are used regularly in subintimal recanalization of chronic occlusions of the iliac and femoro-popliteal arteries and significantly contribute to the high success rate of these interventions. However, the use in tibio-peroneal arteries has only been described in few cases so far. The present work is a retrospective evaluation of the Outback® re-entry device for gaining targeted true lumen access at the level of the tibio-peroneal arteries.

From 9/2017 until 10/2020 the Outback® catheter was used in case of failed spontaneous re-entry at the level of the tibio-peroneal arteries in 14 patients either instead of the usual retrograde approach via a pedal/distal-crural access (n = 11) or in combination with it (n = 3). Baseline demographic and clinical data, morphologic characteristics of the occlusions, procedural succedss, as well as the Society of Vascular Surgery (SVS) runoff score before and after revascularization were documented.

All patients (median age 78 years; range 66-93) suffered from peripheral artery occlusive disease Rutherford stage 4 to 6 with a median lesion length of 12 cm (range 7-35). Technical and procedural success was achieved in all 14 patients. The mean re-entry accuracy was 0.25 cm (range 0-0.8). The SVS runoff score improved from a median of 14.5 (interquartile range IQR 10.8-16.4) to 7 (IQR 6.3-7) (p < 0.01).

The use of the Outback® catheter for targeted tibio-peroneal re-entry is associated with a high technical and procedural success rate and should be considered in case of otherwise failed ante- and retrograde recanalization.

The use of the Outback® catheter for targeted tibio-peroneal re-entry is associated with a high technical and procedural success rate and should be considered in case of otherwise failed ante- and retrograde recanalization.Dogs have remarkable abilities to synergise their behaviour with that of people, but how dogs read facial and bodily emotional cues in comparison to humans remains unclear. Both species share the same ecological niche, are highly social and expressive, making them an ideal comparative model for intra- and inter-species emotion perception. We compared eye-tracking data from unrestrained humans and dogs when viewing dynamic and naturalistic emotional expressions in humans and dogs. Dogs attended more to the body than the head of human and dog figures, unlike humans who focused more on the head of both species. Dogs and humans also showed a clear age effect that reduced head gaze. Our results indicate a species-specific evolutionary adaptation for emotion perception, which is only partly modified for heterospecific cues. These results have important implications for managing the risk associated with human-dog interactions, where expressive and perceptual differences are crucial.

The dormancy release in Avena fatua caryopses was associated with a reduction in the ABA content in embryos, coleorhiza and radicle. The coleorhiza proved more sensitive to KAR

and less sensitive to ABA than the radicle. The inability of dormant caryopses and ABA-treated non-dormant caryopses to complete germination is related to inhibition and delayed of cell-cycle activation, respectively. As freshly harvested Avena fatua caryopses are dormant at 20°C, they cannot complete germination; the radicle is not able to emerge. Both karrikin 1 (KAR

) and dry after-ripening release dormancy, enabling the emergence of, first, the coleorhiza and later the radicle. The after-ripening removes caryopse sensitivity to KAR

and decreases the sensitivity to abscisic acid (ABA). The coleorhiza was found to be more sensitive to KAR

, and less sensitive to ABA, than radicles. Effects of KAR

and after-ripening were associated with a reduction of the embryo's ABA content during caryopsis germination. KAR

was found to later the radicle. The after-ripening removes caryopse sensitivity to KAR1 and decreases the sensitivity to abscisic acid (ABA). The coleorhiza was found to be more sensitive to KAR1, and less sensitive to ABA, than radicles. Effects of KAR1 and after-ripening were associated with a reduction of the embryo's ABA content during caryopsis germination. KAR1 was found to decrease the ABA content in the coleorhiza and radicles. Germination of after-ripened caryopses was associated with the progress of cell-cycle activation before coleorhiza emergence. Inhibition of the germination completion due to dormancy or treating the non-dormant caryopses with ABA was associated with a total and partial inhibition of cell-cycle activation, respectively.Taking the reporting donor SM0 as reference, three new A-π-D-π-A type small molecules donors (SM1, SM2, and SM3) were designed via replacing acceptor moieties. The molecular proprieties affecting the cell performance, such as, frontier molecular orbital, open circuit voltage (Voc), absorption spectrum, vertical and adiabatic ionization potential, vertical and adiabatic electronic affinity, and energy driving force ΔEL-L were investigated through the density functional theory (DFT) and the time dependent density functional theory (TD-DFT). All new designed molecules exhibit reduced energy gap, show a red shift absorption band, small energy binding Eb, moderate Voc, and improve the creation of hole and electron as compared to SM0, which demonstrate that these new designed molecules could be used as a promising donors materials for organic solar cell. link3 Additionally, the three new designed molecules present a larger amount charge transfer qCT, a longer length charge transfer DCT than SM0 and have a smaller reorganization energy of hole λ(h) which improve the charge carrier mobilities.

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