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Evidence points to an incongruence between international drug policy and expert opinion about safety, abuse potential, and therapeutic potential of specific drugs. However, no prior studies have directly explored psychiatrists' attitudes about the current drug schedule. Therefore, we examined whether American psychiatrists' perceptions of four psychoactive drugs differed from those indicated by their schedules.

A quasi-experimental online survey of a convenience sample of psychiatrists in the United States (N=181; Mean age=48.7; Female=35%). Participants were randomized to receive 1-of-4 vignettes, each depicting a depressed patient reporting relief from symptoms after non-prescribed psychoactive drug use (i.e., psilocybin [Schedule I], methamphetamine [SchedII], ketamine [SchedIII], or alprazolam [SchedIV]). Participants responded to questions related to this clinical scenario and then rated the safety, therapeutic, and abuse potentials of these four drugs and alcohol.

There were significant differencesistent with those indicated by their placement in drug schedules. These findings add to a growing consensus amongst experts that the current drug policy is not scientifically coherent.

American psychiatrists' perceptions about safety and abuse/therapeutic potentials associated with certain psychoactive drugs were inconsistent with those indicated by their placement in drug schedules. These findings add to a growing consensus amongst experts that the current drug policy is not scientifically coherent.Cardiovascular diseases are among the primary life-threatening conditions affecting human society. Intermittent fasting is shown to be functional in the prevention of cardiovascular diseases, however, the information on fasting-associated modifications in myocardial biomolecules is limited. This study aimed to determine the impact of 18-h intermittent fasting administered for five weeks on 12 months-old rats using supervised linear discriminant analysis and support vector machine algorithms constructed on spectrochemical data obtained from myocardial tissues. These algorithms revealed gross biomolecular modifications, while quantitative analyses demonstrated higher amounts of saturated lipids (19%), triglycerides (11%), and lipids (56%), in addition to enhancement in membrane dynamics (18%). The concentrations of nucleic acids and glucose are increased by 52%, while the glycogen content is diminished by 61%. The protein carbonylation/oxidation is reduced by 38%, whereas a 35% increase in protein content was measured. Phosphorylated proteins have been calculated to be at higher concentrations in the 13-62% range. The study findings demonstrated significant molecular changes in the myocardium of rats subjected to intermittent fasting.With increasing immigration, it is increasingly important to understand whether and when children consider immigrant peers as co-nationals. Using an experimental design, we examined among native-born preadolescents (8-13 years of age) in the Netherlands whether and when they perceive immigrant peers as co-nationals. First, and in agreement with the social categorization account, we expected that the use of dual identity (vs single ethnic identity) labels for immigrant peers leads to stronger co-nationality perceptions and a related stronger desire for close social contact. Second, and in line with the acculturation account, we expected that an early age of arrival in the country (vs a later age of arrival) leads to stronger perceived co-nationality and related contact desire. The findings support the acculturation account, especially among native-born children with higher national identification. There was no evidence for the social categorization account.The menopausal transition is often accompanied by psycho-vegetative symptoms, including stress and anxiety symptoms. Identifying stress and anxiety and intervening early can have an enormous public health impact. Health care practitioners like obstetrician-gynecologists or family doctors play a critical role in the diagnosis, prevention and treatment of stress and anxiety symptoms or disorders, as they often represent women's primary medical contact during the menopausal transition. check details However, they frequently do not feel confident in identifying and treating mental health problems. The aim of this review was to summarize current (since 2010) knowledge from randomized controlled trials, systematic reviews, and meta-analyses on diagnostics and treatment options, and to provide clinical decision-making algorithms. The recent literature suggests pharmacological, (cognitive) behavioral, and complementary treatments. The choice about which one to use should be discussed with the patient.Surgical resection of chest wall tumours may lead to a loss of ribcage stability and requires reconstruction to allow for physical thorax functioning. When titanium implants are used especially for larger, lateral defects, they tend to break. Implant failures are mainly due to specific mechanical requirements for chest-wall reconstruction which must mimic the physiological properties and which are not yet met by available implants. In order to develop new implants, the mechanical characteristics of ribs, joints and cartilages are investigated. Rib loading is highly dependent on the global thorax kinematics, making implant development substantially challenging. Costal cartilage contributes vastly to the entire thorax load-deformation behaviour, and also to rib loading patterns. Computational models of the thoracic cage require mechanical properties on the global stiffness, to simulate rib kinematics and evaluate stresses in the ribs and costal cartilage. In this study the mechanical stiffness of human costal cartilage is assessed with bending, torsion and tensile tests. The elastic moduli for the bending in four major directions ranged from 2.2 to 60.8 MPa, shear moduli ranged from 5.7 to 24.7 MPa for torsion, and tensile elastic moduli ranging from 5.6 to 29.6 MPa. This article provides mechanical properties for costal cartilage. The results of these measurements are used for the development of a whole thorax finite element model to investigate ribcage biomechanics and subsequently to design improved rib implants.S doping is an effective strategy to improve the potassium-ion storage performance of carbon-based materials. However, due to the large atomic radius of S and poor thermal stability, it is challenging to synthesize carbon materials with high sulfur content by solid-phase transformation. In this work, we designed a multi-cavity structure that can confine the molten S during heat treatment and make it fully react, then achieving high S doping (7.6 at. %). As we known, S doping can also effectively increase the active sites of carbon materials to obtain higher capacity. In addition, through different ex/in-situ characterizations and DFT calculations, we confirmed that the S atoms can effectively expand the interlayer spacing of carbon, which facilitates the intercalation/deintercalation reaction of K+, thereby significantly improving the rate performance. Therefore, benefiting from the effect of S-doping, the sample exhibits high reversible specific capacity (401.0 mAh g-1 at 0.1 A/g) and rate performance (167.2 mAh g-1 at 5 A/g). The as-assembled K+ hybrid capacitor delivers both high energy density and power density (138.5 W h kg-1 and 7692.5 W kg-1, respectively). This work provides a new approach to design S content carbon-based materials for high performance K+ storage.Most metal sites and some non-metallic sites such as carbon and nitrogen are usually considered to be traditional active sites during peroxymonosulfate (PMS) activation. However, as an important non-metallic element, the actual role of silicon (Si) in PMS activation still remains unclear. In this work, taking iron silicate (FeSi) as an example, the role of the Si region in PMS activation was clearly revealed. The experiments and density functional theory (DFT) calculation results showed that besides the traditional Fe sites, the Si also played a non-negligible role during PMS activation. In FeSi containing oxygen vacancies (Ovac), Fe-Si was the active site instead of Fe-Fe. The Bard charge results implied that the presence of Ovac tuned the electronic properties of FeSi, making the Si participate in PMS activation. This work deepened understanding of the role of Si in silicates for PMS activation and provided a theoretical basis for the development of excellent Si-based catalysts.

Understanding the microscopic driving force of water wetting is challenging and important for design of materials. The relations between structure, dynamics and hydrogen bonds of interfacial water can be investigated using molecular dynamics simulations.

Contact angles at the alumina (0001) and (112‾0) surfaces are studied using both classical molecular dynamics simulations and experiments. To test the superhydrophilicity, the free energy cost of removing waters near the interfaces are calculated using the density fluctuations method. The strength of hydrogen bonds is determined by their lifetime and geometry.

Both surfaces are superhydrophilic and the (0001) surface is more hydrophilic. Interactions between surfaces and interfacial waters promote a templating effect whereby the latter are aligned in a pattern that follows the underlying lattice of the surfaces. Translational and rotational dynamics of interfacial water molecules are slower than in bulk water. Hydrogen bonds between water and both surfaina surfaces strong water-to-aluminol hydrogen bonds.Here in this article, a halloysite nanotube/reduced graphene oxide/cobalt nickel composite (HNT/rGO/CoNi) was synthesized by co-precipitation and subsequent calcination processes. The microstructure, morphology, and chemical composition of the as-synthesized samples were characterized by X-ray diffractometer, Raman spectra, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. The electromagnetic absorption performances of the composites/paraffin wax hybrids were tested in the frequency range 2-18 GHz. It was found that the synergistic attenuation of electricity and magnetism, as well as the fairly good impedance matching properties together have led to the impressive electromagnetic absorption performance of the optimized product. The maximum reflection loss can reach - 69.77 dB with the thickness of 2.38 mm at 14.72 GHz, and an effective absorption bandwidth of about 7.12 GHz (10.88 GHz-18.00 GHz) can be achieved in the HNT/rGO/CoNi (30) composite. The excellent microwave absorption performance was estimated to originate from the combination of multiple electromagnetic loss mechanisms, including interfacial polarization between graphene and magnetic nanoparticles, dipole orientation polarization caused by the defects of graphene, the natural ferromagnetic resonance, and eddy current of the magnetic nanoparticles. Furthermore, the halloysite plays the roles of improving dispersion of the magnetic nanoparticles as well as adjusting the complex permittivity of the composite. This work provides a new strategy for the design and fabrication of high performance microwave absorbing materials with natural and readily available components.