Desaigoodwin2524

Hence, this study provides new insights into combined therapeutic strategies for patients with ALK-rearranged lung cancer.Several studies have reported a possible association between leucocyte telomere length (LTL) and cardio-metabolic diseases (CMDs). However, studies investigating such association are lacking in South Africa despite having a very high prevalence of CMDs. We investigated the association between LTL and CMD risk profile in a black South African population. This was a cross-sectional study with participants > 21 years of age and residing in five townships in Cape Town. CMD markers were compared between men and women and across quartiles of LTL. Linear and logistic regressions relate increasing quartile and Log10LTL with CMD risk profile, with appropriate adjustment. Among 676-participants, diabetes, obesity and hypertension prevalence were 11.5%, 23.1% and 47.5%. Waist-circumference, hip-circumference and highly sensitive c-reactive protein values were significantly higher in women (all p  less then  0.001), while HDL-C (p = 0.023), creatinine (p = 0.005) and gamma glutamyl transferase (p  less then  0.001) values were higher in men. In age, sex and BMI adjusted linear regression model, Log10 of LTL was associated with low HDL-C (beta = 0.221; p = 0.041) while logistic regression showed a significant association between Log10LTL and prevalent dyslipidaemia characterised by high LDL-C. In this population, the relationship between LTL and CMD is weak given its association with only HDL-C and LDL-C.In this paper, we present a general equivalent-circuit interpretation of finite magnetic metasurfaces interacting with an arbitrary arrangement of RF coils operating in near-field regime. The developed model allows to derive a physical interpretation of the interactions between the metasurface and the surrounding RF coils, both transmitting and receiving. Indeed, especially for near-field applications, the metasurface presence modifies the behavior of each RF coil differently, due to the specific reciprocal interactions. Hence, the proposed approach introduces a source-related complex magnetic permeability matrix, overcoming the traditional bulk definition. To prove the model validity against full-wave simulations, we present two significant test cases, commonly used in practical applications. The former is represented by the simple metasurface-coil arrangement from which important and fundamental considerations can be drawn. The latter system is composed by a transmitting and a receiving coil with a metasurface in between; detailed explanations on the metasurface interactions with both the RF coils are developed. Finally, we also achieved an excellent agreement between the numerical results and the measurements obtained through fabricated prototypes. In summary, the circuit interpretation herein presented, in addition to the rigorous electromagnetic theoretical approaches already appeared in the open literature, reveals useful in providing quantitative, practical, and easy-to-handle guidelines for the design and physical understanding of finite magnetic metasurfaces interacting with arbitrary RF coils arrangements in the near-field regime.Spatial aggregates of survey and web search data make it possible to identify the heterogeneous well-being effects of social media platforms. This study reports evidence from different sources of longitudinal data that suggests that the well-being effects of social media differ across platforms and population groups. The well-being effects of frequent social media visits are consistently positive for Facebook but negative for Instagram. Group-level analyses suggest that the positive well-being effects are experienced mainly by white, high-income populations at both the individual and the county level, while the adverse effects of Instagram use are observed on younger and Black populations. The findings are corroborated when geocoded web search data from Google is used and when self-reports from surveys are used in place of region-level aggregates. Greater Instagram use in regions is also linked to higher depression diagnoses across most sociodemographic groups.Rosmarinus officinalis L. is an imperative herb used in pharmaceutical yet knowledge on chemical and activity profile of essential oil (EO) to harvest seasons and accessions from the Himalayan region is limited. Thus, accessions were evaluated to determine the EO content, compositional, antimicrobial, and cytotoxic potential of rosemary in different harvest seasons during 2018‒2019. EO content was 30.5% higher in IHBT/RMAc-1 compared with IHBT/RMAc-2 accession while 27.9% and 41.6% higher in the autumn as compared with summer and rainy season, respectively. Major EO compound was 1,8-cineole; ranged from 32.50‒51.79% during harvest seasons and 38.70‒42.20% in accessions. EO was active against both the tested Gram-positive bacteria (Micrococcus luteus MTCC 2470 and Staphylococcus aureus MTCC 96). EOs showed inhibition of Gram-negative bacteria (Salmonella typhi MTCC 733), while Klebsiella pneumoniae MTCC 109 was found to be resistant. The rosemary EO of T1 (Rainy season IHBT/RMAc-1) was most effective against S. aureus MTCC 96 with the minimum inhibitory concentration (MIC) of 4% (v/v). In vitro cytotoxicity evaluation showed no potential anti-proliferative activity of EO. The rosemary EO profile in the western Himalayan region was influenced by harvesting seasons and genetic variability within the accessions; furthermore, a promising antibacterial agent in pharmaceutical and flavour industries.The association between serum free hemoglobin (sfHb) level and white matter hyperintensity (WMH) volume is controversial. This study is to examine this association considering nonlinearity, sex dimorphism, and WMH type. We enrolled 704 older adults among the participants of the Korean Longitudinal Study on Cognitive Aging and Dementia and visitors to the Dementia Clinic of Seoul National University Bundang Hospital. We measured sfHb level in the venous blood and WMH volume (VWMH) using fluid-attenuated inversion recovery magnetic resonance images. The association between sfHb level and periventricular VWMH was linear in men (linear regression; β =  - 0.18, p = 0.006) and U-shaped in women (restricted cubic spline; F = 6.82, p  less then  0.001). sfHb level was not associated with deep VWMH in either sex. These findings were also observed in participants without anemia. All trans-Retinal concentration To conclude, sfHb level is associated with periventricular VWMH in older adults of both sexes. Maintaining an optimal sfHb level may contribute to the prevention of WMH.The mass-flow-rate characteristics of high-pressure pneumatic servo valves (HPSVs) have an important effect on the dynamic performance of high-pressure servo systems. However, these characteristics are difficult to obtain by theoretical calculations and flowmeter measurements owing to the compressibility of high-pressure gas. In this paper, a new measurement method of the mass-flow-rate characterization parameters of HPSVs is proposed based on the principle of the series connection sonic discharge of valve orifices. The effective cross-sectional area and critical pressure ratio of the servo valve orifices can be accurately and efficiently determined by connecting two valve orifices in series and exchanging the flow sequence of the two valve orifices. The two assumptions including the sonic and adiabatic discharge of the proposed measurement method were verified. A comparison between the test and simulation data showed that the accuracy of the measured effective cross-sectional area and critical pressure ratio of the HPSV was high. The measured critical pressure ratio ranged from 0.46 to 0.50, and the flow coefficient represented by the effective cross-sectional area variation decreased with increasing valve opening. These findings have general implications for the accurate design, analysis, and control of high-pressure pneumatic servo systems.Understanding the recovery of whale populations is critical for developing population-management and conservation strategies. The southern right whale (SRW) Eubalena australis was one of the baleen whale species that has experienced centuries of exploitation. We assess here for the first time the population dynamics of the SRW from the southwestern Atlantic Ocean at the regional level to measure numerically the effect of whaling and estimate the population trend and recovery level after depletion. We reconstructed the catch history of whaling for the period 1670-1973 by an extensive review of different literature sources and developed a Bayesian state-space model to estimate the demographic parameters. The population trajectory indicated that the pre-exploitation abundance was close to 58,000 individuals (median = 58,212; 95% CI = 33,329-100,920). The abundance dropped to its lowest abundance levels in the 1830s when fewer than 2,000 individuals remained. The current median population abundance was estimated at 4,742 whales (95% CI = 3,853-6,013), suggesting that the SRW population remains small relative to its pre-exploitation abundance (median depletion P2021 8.7%). We estimated that close to 36% of the SRW population visits the waters of the Península Valdés, the main breeding ground, every year. Our results provide insights into the severity of the whaling operation in the southwestern Atlantic along with the population´s response at low densities, thus contributing to understand the observed differences in population trends over the distributional range of the species worldwide.We demonstrate a simple experimental technology for characterizing the gas permeation properties of H2, He, N2 and Ar absorbed in polymers. This is based on the volumetric measurement of released gas and an upgraded diffusion analysis program after high-pressure exposure. Three channel measurements of sorption content of gases emitted from polymers after decompression are simultaneously conducted, and then, the gas uptake/diffusivity as a function of exposed pressure are determined in nitrile butadiene rubber (NBR), ethylene propylene diene monomer (EPDM) rubbers, low-density polyethylene (LDPE) and high-density polyethylene (HDPE), which are used for gas sealing materials under high pressure. The pressure-dependent gas transport behaviors of the four gases are presented and compared. Gas sorption follows Henry's law up to 9 MPa, while pressure-dependent diffusion behavior is not observed below 6 MPa. The magnitude of the diffusivity of the four gases decreases in the order DHe > DH2 > DAr > DN2 in all polymers, closely related to the kinetic diameter of the gas molecules. The dependence of gas species on solubility is in contrast to that on diffusivity. The linear correlation between logarithmic solubility and critical temperature of the gas molecule was newly observed.The total alkaloids extracted from the seeds of Sophora moorcroftiana (TAs-SM) have the potential to treat alveolar echinococcosis, a disease included by the WHO in a list of 17 key neglected diseases world-wide. The aims of the current study were first to develop a supercritical fluid extraction (SFE) method for optimizing TAs-SM extraction, and second, to develop an optimized method for evaluating TAs-SM pharmacokinetics in vivo. The Box-Behnken response surface method was used to optimize the extraction process, and ultra-high liquid chromatography coupled with high resolution electrospray mass spectrometry (UPLC-HR-ESI-MS) was used to determine the pharmacokinetics of TAs-SM in SD rats. The results indicated the following optimal SFE extraction conditions pressure = 31 MPa, temperature = 70 °C, time = 162.18 min. With these parameters, total alkaloids could be extracted from each gram of S. moorcroftiana, with the total content being 68.88 μg. The linear range of UPLC-HR-ESI-MS is 0.78-200.00 ng/ml, R2 > 0.