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This review introduces various commonly used nanoparticulate systems in biomedical research and their pharmacokinetic (PK) attributes, then focuses on the various physicochemical and physiological factors affecting the in vivo disposition of chemotherapeutic agents encapsulated in nanoparticles in recent years. Further, it provides a review of the current landscape of soft nanoparticulate formulations for the two most widely investigated anticancer drugs, paclitaxel, and doxorubicin, that are either approved or under investigation. Formulation details, PK profiles, and therapeutic outcomes of these novel strategies have been discussed individually and in comparison, to traditional formulations. This article is categorized under Nanotechnology Approaches to Biology > Cells at the Nanoscale Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.Despite substantial evidence of the role of substance use in intimate partner violence (IPV), little is known about the impact of substance use on stability and change in the experience of IPV as both a perpetrator and a victim. Using an ethnically diverse sample of 232 men in early adulthood (mean age = 29.1, SD = 0.91), this study defined typologies of IPV based on men's reports of both perpetration and victimization; examined the potential impact of substance use, including alcohol and marijuana use, on IPV typologies over two measurement occasions; and quantified stability and change in these typologies over time. Patterns of IPV were characterized by three classes at each time point no IPV, psychological aggression, and physical aggression. Men's regular marijuana use was associated with physical aggression contemporaneously and prospectively. Partner's problem alcohol use was associated with psychological aggression contemporaneously, suggesting that women's problem alcohol use could be a risk factor for their own and their partner's IPV perpetration. IPV appeared to remain somewhat stable over time with 67% of men remaining in the same IPV class. Among those who did transition from one typology to another, it was most often to a less severe IPV typology. Regular marijuana users were more likely to be in the physical aggression typology rather than the no IPV typology, with a higher probability of transitioning to a more severe IPV typology than nonusers. The present study has implications for prevention and intervention efforts by its ability to identify men who are at greatest risk for continued or increased violence and underscores that men's marijuana use may exacerbate IPV.Urea electrolysis is of great interest for energy-related applications, but it is limited by a complex six-electron transfer process with slow kinetics. Herein, the in situ growth of Cr-doped Co2P homogeneous nanoneedle arrays on nickel foam substrates (Cr-Co2P/NF) was reported for the first time by a typical hydrothermal and low-temperature phosphorization process. The appropriate amount of Cr doping was found to promote the electronic modulation of active centers and the expansion of the specific active surface area, resulting in the superior performance of the urea oxidation reaction (UOR). It is noteworthy that Cr0.4-Co2P/NF exhibited a superior performance of the UOR at an onset potential of 1.290 V and a cell voltage of 1.333 V at 50 mA cm-2 in 1 M KOH containing 0.5 M urea, which is one of the best catalytic activities reported so far. The experimental results demonstrate that the enhanced catalytic activity can be attributed to favorable electronic regulation, an improved charge transfer rate and increased exposure to active sites. Density functional theory (DFT) calculation indicates that the appropriate doping of Cr effectively regulates and controls the adsorption energy of urea and the conductivity of the Co2P material itself. CDK2-IN-73 This work provides new ideas for the development of robust catalysts for the electrolysis of urea through doping strategies.A new method for the synthesis of azaaromatic vinylcyclopropanes (VCPs) has been disclosed in this paper by using pyrrole or indole derivatives as nucleophilic reagents to react with vinylidenecyclopropane-diesters (VDCP-diesters) in the presence of a Pd catalyst, a phosphine ligand and a base under mild conditions in up to 98% yield with a reasonable substrate scope. This reaction is one of the few examples of hydroamination at electron-rich allene's β-position. A plausible reaction mechanism has also been proposed through a zwitterionic π-propargyl N-palladium species according to the previous work and the obtained deuterium labeling experimental result.HLA-DPA1*0272 differs from HLA-DPA1*02020201 by one nucleotide substitution at position 4273, codon 86 located in exon 3.Transferable local pseudopotentials (LPPs) are essential for fast quantum simulations of materials. However, various types of LPPs suffer from low transferability, especially since they do not consider the norm-conserving condition. Here we propose a novel approach based on a deep neural network to produce transferable LPPs. We introduced a generalized Kerker method expressed with the deep neural network to represent the norm-conserving pseudo-wavefunctions. Its unique feature is that all necessary conditions of pseudopotentials can be explicitly considered in terms of a loss function. Then, it can be minimized using the back-propagation technique just with single point all-electron atom data. To assess the transferability and accuracy of the neural network-based LPPs (NNLPs), we carried out density functional theory calculations for the s- and p-block elements of the second to the fourth periods. The NNLPs outperformed other types of LPPs in both atomic and bulk calculations for most elements. In particular, they showed good transferability by predicting various properties of bulk systems including binary alloys with higher accuracy than LPPs tailored to bulk data.Per the American Society for Apheresis, therapeutic plasma exchange (TPE) is a Category III indication in the management of immune thrombocytopenia (ITP). This nationally representative study evaluates TPE utilization in hospitalized adults with a primary admission diagnosis of ITP. Hospitalizations with ITP as the primary admitting diagnosis were analyzed from the 2010 to 2014 National Inpatient Sample, the largest all-payer inpatient database in the United States. Univariate and multivariable logistic regressions were used to determine clinical outcomes in ITP patients undergoing TPE. Sampling weights were applied to generate nationally representative estimates. From 2010 to 2014, there were a total of 56,149 admissions with a primary admitting diagnosis of ITP, of which 0.66% admissions (n = 372) also coded TPE. Most subjects undergoing TPE were the highest disease severity class major (34.6%) and extreme severity (31.0%), by all-patients refined diagnoses-related groups severity of illness subclass. After multivariable analysis, underlying severity of illness remained the most significant predictor of TPE (P  less then  .001). ITP admissions with TPE had a high rate of comorbidities (50%) and significantly longer mean length of hospital stay than those without (P  less then  .001). TPE was reported in ~0.6% of hospitalizations with ITP as the primary diagnosis in this nationally representative sample from 2010 to 2014. TPE was performed in patients with the highest severity of underlying illness, and higher rates of comorbidities.

There is limited information on the effects of statins on the outcomes of liver transplantation (LT), regarding either their use by LT recipients or donors.

To analyse the association between statin exposure and recipient and graft survival.

We included adult LT recipients with deceased donors in a nationwide prospective database study. Using a multistate modelling approach, we examined the effect of statins on the transition hazard between LT, biliary and vascular complications and death, allowing for recurring events. The observation time was 3 years.

We included 998 (696 male, 70%, mean age 54.46 ± 11.14 years) LT recipients. 14% of donors and 19% of recipients were exposed to statins during the study period. During follow-up, 141 patients died; there were 40 re-LT and 363 complications, with 66 patients having two or more complications. Treatment with statins in the recipient was modelled as a concurrent covariate and associated with lower mortality after LT (HR=0.35; 95% CI 0.12-0.98; p=0.047), as well as a significant reduction of re-LT (p=0.004). However, it was not associated with lower incidence of complications (HR=1.25; 95% CI=0.85-1.83; p=0.266). Moreover, in patients developing complications, statin use was significantly associated with decreased mortality (HR=0.10; 95% CI=0.01-0.81; p=0.030), and reduced recurrence of complications (HR=0.43; 95% CI=0.20-0.93; p=0.032).

Statin use by LT recipients may confer a survival advantage. Statin administration should be encouraged in LT recipients when clinically indicated.

Statin use by LT recipients may confer a survival advantage. Statin administration should be encouraged in LT recipients when clinically indicated.Retraction of 'NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway' by Chenfei Kong et al., Biomat. Sci., 2019, 7, 2559-2570, https//doi.org/10.1039/C8BM01007B.This study offers a historical introduction to psychiatry and music therapy in Japan in the late nineteenth and early twentieth centuries, followed by English translations of related excerpts from Shūzō Kure's Psychotherapy (1916). Music was used as preventive healthcare during the Edo period (1603-1867). This continued into the Meiji period (1868-1912), when European music was also employed by psychiatrists alongside traditional Japanese songs. Kure (1865-1932) is known as the father of Japanese psychiatry and his work best illustrates the links between music and psychiatry in Japan at the turn of the century, showing the integration of European and Japanese theories and practices.In the past decades, there has been an increasing scholarly interest in understanding the development of psychiatry and mental health in non-Western worlds in the modern period. Several collective efforts have been made on the East Asian part, and this special issue has selected the examples of the countries of China, Japan, Korea, Hong Kong and Taiwan. Articles have utilized social and political constructions of psychiatric discourse, as well as the use of case files to research patients' experiences in mental hospitals. Through these historiographies, connections and meanings of East Asian psychiatry are discussed in both global and local contexts.This paper explores domestic dynamics in the complex making of institutional psychiatry in Japan in c. 1920-45. It mainly examines gender issues between the relatively long-lasting system of the family care of mentally ill members and the use of freshly introduced systems of psychiatric hospitals. I shall look at the record of Ohji Brain Hospital (1901-45) in Tokyo, which has several thousands of case histories mainly in Tokyo c. 1920-45. From the analysis of the cases of male and female patients, as well as the complex situations of their households and kin groups, I shall look at the gender issues in the making of the psychiatric hospital regime.