Demanthughes7065

A backstepping controller augmented with a state predictor is proposed to control a quadrotor over a network subjected to both state and input time delay. The state predictor predicts the future values of the states by taking the measured delayed states as input. A backstepping control law is further designed based on these predicted states. It is shown with the aid of the Lyapunov-Razumikhin theorem that the error dynamics of the predictor is asymptotically stable. The cascade of state predictor and backstepping controller makes the tracking error dynamics of the quadrotor asymptotically stable. Simulation results are presented to validate the proposed approach.Vibration-based feature extraction of multiple transient fault signals is a challenge in the field of rotating machinery fault diagnosis. Variational mode decomposition (VMD) has great potential for multiple faults decoupling because of its equivalent filtering characteristics. However, the two key hyper-parameters of VMD, i.e., the number of modes and balancing parameter, require to be predefined, thereby resulting in sub-optimal decomposition performance. Although some studies focused on the adaptive parameter determination, the problems in these improved methods like mode redundancy or being sensitive to random impacts still need to be solved. To overcome these drawbacks, an adaptive variational mode decomposition (AVMD) method is developed in this paper. In the proposed method, a novel index called syncretic impact index (SII) is firstly introduced for better evaluation of the complex impulsive fault components of signals. It can exclude the effects of interference terms and concentrate on the fault impacts effectively. TH5427 purchase The optimal parameters of VMD are selected based on the index SII through the artificial bee colony (ABC) algorithm. The envelope power spectrum, proved to be more capable for fault feature extraction than the envelope spectrum, is applied in this study. Analysis on simulated signals and two experimental applications based on the proposed method demonstrates its effectiveness over other existing methods. The results indicate that the proposed method outperforms in separating impulsive multi-fault signals, thus being an efficient method for multi-fault diagnosis of rotating machines.

Neuroblastoma (NB) is the most common solid tumor in children. Studies showed that long-chain noncoding RNA (lncRNA) HCP5 played an important role in tumorigenesis, but its role in NB remained unclear. This study aims to determine the role of HCP5 in NB and its possible molecular mechanism.

We analyzed the expression levels of miRNA-186-5p and HCP5 in neuroblastoma and neuroblastoma cell lines SHSY-5Y, Kelly, NBL-S and SK-N-AS, and explored their roles.

We found that the HCP5 expression was up-regulated in NB tissues and cells. The higher the HCP5 expression in NB cells, the stronger the ability of clone formation. Down regulation of the HCP5 expression inhibited the proliferation of NB cells and the growth of subcutaneous transplanted tumor in nude mice. HCP5 could competitively bind miR-186-5p, while miR-186-5p could target the 3'-UTR of MAP3K2. The expression level of miR-186-5p was down regulated while the expression level of MAP3K2 was up-regulated in NB tissues. The expression level of HCP5 and miR-186-5p, the expression level of miR-186-5p and MAP3K2 were negatively correlated. The decreased proliferation of NB cells induced by down-regulation of HCP5 expression can be counteracted by miR-186-5p inhibitor or MAP3K2, and vice versa.

This study showed that lncRNA HCP5, as ceRNA, regulated MAP3K2 to promote NB progression through competitive binding of miR-186-5p. We revealed a new signaling pathway that mediates NB, which provided a new target for the diagnosis and treatment of NB.

This study showed that lncRNA HCP5, as ceRNA, regulated MAP3K2 to promote NB progression through competitive binding of miR-186-5p. We revealed a new signaling pathway that mediates NB, which provided a new target for the diagnosis and treatment of NB.

Experience with autologous blood patch (ABP) pleurodesis for persistent air leak in the pediatric population is limited. The purpose of this series was to describe the experience with ABP at a single tertiary children's hospital.

A retrospective study was performed of all thoracic procedures done by the pediatric surgery service over three years.

Ten patients underwent a total of 17 ABPs. The median age of patients was 12 years (IQR 6-16). The most common underlying reasons for a thoracic procedure included blebectomy for spontaneous pneumothorax (2), need for lung biopsy (2), resection of known malignant tumor (2), and empyema (2). The median number of days of persistent air leak before first ABP was 7.5 days (IQR 7-10). A second ABP was performed in 6 cases with a third procedure performed in one case. None of the patients developed respiratory compromise during ABP and no infectious complications were identified following ABP.

Our cohort demonstrates that ABP for persistent air leak following thoracic surgery is effective with minimal morbidity in children. We believe ABP can be used early and in patients with a broad range of underlying lung pathology.

Our cohort demonstrates that ABP for persistent air leak following thoracic surgery is effective with minimal morbidity in children. We believe ABP can be used early and in patients with a broad range of underlying lung pathology.Fluorescence-guided surgery (FGS) is an increasingly available and popular method of visual field augmentation. The basic premise of FGS entails injection of fluorescent indocyanine green (ICG) and subsequent detection with a near-infrared (NIR) camera. For pediatric surgical oncologists, FGS remains experimental but is a promising modality for identifying tumor margins, locating metastases, performing sentinel lymph node biopsies, protecting peritumoral structures of interest, and facilitating reconstruction. Familiarity with basic ICG pharmacokinetics and NIR detection optics is critical for surgeons wishing to judiciously use FGS, as its success is firmly grounded in a thorough understanding of its capabilities and limitations. In this practical guide, we outline several well-described and innovative FGS applications by disease type, including their methods of administration, modes of detection, and typical ICG dosing paradigms. LEVEL OF EVIDENCE V.