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Green tea has many health benefits and is the most consumed type in China. However, the heavy metals and contaminants in tea can also pose a great risk to human health. In this study, mercury (Hg) concentration in green tea collected from 11 provinces in China was examined. The leaching characteristics of Hg during brewing and the associated exposure to drinkers were also evaluated. Results indicated a low potential of Hg accumulation in green tea. The Hg content of green tea from Wanshan District, Guizhou Province-which has the largest Hg mine in China and is severely contaminated by Hg-could be limited by controlling the harvest time of tea leaves. The average Hg content of green tea from 43 tea production sites in China was only 6.3 ± 6.4 µg/kg dry weight. The brewing experiments of green tea showed that the leaching ratio of Hg was 22.61 ± 7.58% for 40 min of a single brew, and increased to 32.83 ± 12.37% after four rounds (3 min/ round) of brewing. The leaching of Hg from tea leaves was significantly affected by leaching time, temperature, and solid-liquid ratio but not by water hardness. The risk of Hg exposure from green tea intake was found to be very low, with an average hazard quotient (HQ) value of only 1.82 ± 1.85% for a single brew in 40 min and 2.64 ± 2.68% after four rounds of brewing. However, in some highly contaminated areas, with HQ values as high as 43.12 ± 2.41%, green tea intake may still pose a high risk of Hg exposure, and this risk should not be ignored.

To investigate whether working with intrusive images and the use of imagery processes would be beneficial to treating depression, an imagery-based intervention (imagery rescripting, IR) was compared with a more commonly used verbal-based technique (cognitive restructuring, CR). The study aimed not only to test the efficacy of IR as a brief modular treatment for depression, but to explore whether such experiential use of imagery would alleviate the abstract-evaluative, verbal processes of rumination and worry.

Forty-one participants diagnosed with clinical depression and who also reported intrusive images underwent one assessment session of imagery properties before they were randomly assigned to an IR group or to an active control group of CR. They then received three weekly sessions of treatment, and outcomes were measured before and after treatment, as well as at two-month follow-up.

The results showed that IR was equally if not more effective than CR in alleviating depression. Significant differential reductions in rumination, worry and experiential avoidance between treatments added support to the technique's experiential nature, and possibly, a defusing out of an abstract-evaluative mode of processing.

Only self-report measures were used, with a small number of treatment sessions by one clinician.

The findings support the therapeutic potential of imagery modalities in the treatment of depression, which compared to cognitive restructuring, appear to bring about more significant emotional change with time (clinical trial registered at the Joint CUHK-NTEC CREC Ref. No. 2015.458).

The findings support the therapeutic potential of imagery modalities in the treatment of depression, which compared to cognitive restructuring, appear to bring about more significant emotional change with time (clinical trial registered at the Joint CUHK-NTEC CREC Ref. No. 2015.458).

Deep brain stimulation (DBS) of the mesencephalic locomotor region, composed of the pedunculopontine (PPN) and cuneiform (CuN) nuclei, has been proposed to treat dopa-resistant gait and balance disorders in Parkinson's disease (PD). Here, we report the long-term effects of PPN- or CuN-DBS on these axial disorders.

In 6 PD patients operated for mesencephalic locomotor region DBS and prospectively followed for more than 2 years, we assessed the effects of both PPN- and CuN-DBS (On-dopa) in a cross-over single-blind study by using clinical scales and recording gait parameters. Patients were also examined Off-DBS.

More than 2 years after surgery, axial and Tinetti scores were significantly aggravated with both PPN- or CuN-DBS relative to before and one year after surgery. Gait recordings revealed an increased double-stance duration with both PPN- or CuN-DBS, higher swing phase duration with CuN-DBS and step width with PPN-DBS. With PPN- versus CuN-DBS, the step length, velocity and cadence were significantly higher; and the double-stance and turn durations significantly lower. Irrespective the target, we found no significant change in clinical scores Off-DBS compared to On-DBS. The duration of anticipatory postural adjustments as well as step length were lower with versus without PPN-DBS. We found no other significant changes in motor, cognitive or psychiatric scores, except an increased anxiety severity.

In this long-term follow-up study with controlled assessments, PPN- or CuN-DBS did not improve dopa-resistant gait and balance disorders with a worsening of these axial motor signs with time, thus indicating no significant clinical effect.

In this long-term follow-up study with controlled assessments, PPN- or CuN-DBS did not improve dopa-resistant gait and balance disorders with a worsening of these axial motor signs with time, thus indicating no significant clinical effect.

Physical activity can improve brain health in people with multiple sclerosis (PwMS). One of the underlying mechanisms can be the modulation of gut bacteria. The association of different intensity of physical activity in a lifetime; and brain volume, lesion volume, and number, and gut bacteria counts were investigated in the current study.

Forty-five PwMS were recruited, and magnetic resonance imagining was used to evaluate brain volume, lesion volume, and number. Also, stool samples were taken for evaluation faecalibacterium prausnitzii, akkermansia muciniphila, prevotella, and bacteroidescount. Moreover, lifetime physical activity was assessed using the adapted version of the historical activity questionnaire.

Data revealed a significant association of physical activity with brain volume (r=0.41), lesion volume (r=-0.35), lesion number (r=-0.37), akkermansia muciniphila (r=-0.34), prevotella (r=0.52) and bacteroides (r=-0.32) count (p<0.05). Moderate-intensity of physical activity was associated with brain volume (r=0.33), lesion volume (r=-0.38), prevotella (r=0.35) and bacteroides (r=-0.40) count (p<0.05). Moreover, vigorous-intensity of physical activity was associated with brain volume (r=0.38), lesion number (r=-0.39), akkermansia muciniphila (r=-0.30) and prevotella (r=0.56) count (p<0.05).

Our results suggest that lifetime physical activity is associated with brain health and gut bacteria count in PwMS. Additionally, the heterogeneity of the association of the physical activity intensities with the studied variables indicates the importance of using different intensities of physical activity to greater benefit from physical activity.

Our results suggest that lifetime physical activity is associated with brain health and gut bacteria count in PwMS. Additionally, the heterogeneity of the association of the physical activity intensities with the studied variables indicates the importance of using different intensities of physical activity to greater benefit from physical activity.

To investigate the duration of B-cell depletion in a cohort of patients receiving ocrelizumab or rituximab for multiple sclerosis (MS) or neuromyelitis optica spectrum disorders (NMOSD).

We retrospectively searched our database for patients diagnosed with MS or NMOSD, who were receiving ocrelizumab or rituximab and had available CD19 measurements. We collected demographic data, infusion doses, infusion dates, CD19 absolute counts and percentages, and their collection dates. We paired each infusion with the subsequent CD19 measurements recorded before the next infusion, discarding measurements done during a washout period of 30 days after each infusion. We applied three definitions for B-cell depletion, the most stringent of which was an absolute B-cell count ≤20 cells/uL.

From 695 patients with demyelinating diseases in our database, over the period of January 1st 2010 to March 1st 2020, we identified 188 patients (178 with MS and 10 with NMOSD), who had received ocrelizumab or rituximab and had availabinfusion with ocrelizumab and rituximab beyond 6-months guided by B-cell measurements.

Multiple sclerosis is a disease that can reduce the quality of life with a physical disability, neuropsychiatric disorders, and cognitive dysfunctions. Therefore, multiple sclerosis treatment should include treatments for cognitive and neuropsychiatric disorders and pharmacological treatments. This study aimed to examine the effects of exercise on neuropsychiatric disorders, problem-solving skills, and emotional intelligence in multiple sclerosis patients.

Thirty-six female relapsing-remitting multiple sclerosis patients aged between 18 and 45 years, with an Expanded Disability Status Scale between 1 and 3, who were diagnosed with definitive multiple sclerosis according to the revised McDonald criteria were included in the study. Participants completed outcome measures before and after the 12-week exercise program. Demographic/clinical information of the participants was obtained at baseline, neurological examinations were performed, and graded exercise testing on a bicycle ergometer was performed to detenificant difference was observed in the Emotional Intelligence Scale total score after the treatment (p<0.01).

The results of our study showed that exercise in relapsing-remitting multiple sclerosis patients provided significant improvements in emotional intelligence, improved neuropsychiatric parameters, and increased problem-solving skills. In addition, to the best of our knowledge, this study is the first study in the literature to investigate the effect of physical activity exercises on problem-solving skills in multiple sclerosis patients.

The results of our study showed that exercise in relapsing-remitting multiple sclerosis patients provided significant improvements in emotional intelligence, improved neuropsychiatric parameters, and increased problem-solving skills. AT7867 In addition, to the best of our knowledge, this study is the first study in the literature to investigate the effect of physical activity exercises on problem-solving skills in multiple sclerosis patients.

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally via mRNA degradation. As a result, they have an impact on a variety of pathways in organisms that are important for both health and disease. miRNAs can be used as potential diagnostic, prognostic and therapeutic biomarkers for immune and nervous system-related diseases such as MS.

Differentially expressed miRNAs from peripheral blood samples of patient and control groups were selected from NCBI GEO Datasets using GEO2R. Common miRNAs and their related pathways were analyzed using miRNet, miRWalk, DIANA mirpath, KEGG pathway. Target genes and their protein-protein interactions were also evaluated using STRING and GeneMANIA.

We found 12 common miRNAs, four of which were determined to be more important in MS-related pathways such as the immune and neural signaling networks. These include pathways neurotrophin, JAK-STAT, B cell receptor, ErbB, MAPK, Fc gamma R-mediated phagocytosis, Chemokine and T cell receptor signaling pathways. Moreover, target gene analyses were performed and MAPK1, PIK3CD, PIK3R1, PIK3R2, PIK3R3, PIK3R5, AKT2, SOS2, RAF1 genes were found.