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With the addition of adjuvants and linkers, the construct size was 547 amino acids. The developed MEV structure was predicted to be antigenic, non-toxic, non-allergenic, and firm in nature. I-tasser anticipated the 3D construction of MEV. Moreover, disulfide engineering further enhanced the stability of the final vaccine protein. In-silico cloning and vaccine codon optimization were done to analyze the up-regulation of its expression. The outcomes established the vaccine's immunogenicity and safety profile, besides its aptitude to encourage both humoral and cellular immune responses. The offered vaccine, grounded on our in-silico investigation, may be considered for ovarian cancer immunotherapy.

The online version contains supplementary material available at 10.1007/s10989-021-10294-w.

The online version contains supplementary material available at 10.1007/s10989-021-10294-w.

Research on models of integrated health care for hypertension and diabetes is one of the priority issues in the world. There is a lack of knowledge about how integrated care is implemented in practice. Our study assessed its implementation in six areas identification of patients, treatment, health education, self-management support, structured collaboration and organisation of care.

This was a mixed methods study based on a triangulation method using quantitative and qualitative data. It took place in different types of primary health care organisations, in one urban and two rural regions of Slovenia. The main instrument for data collection was the Integrated Care Package (ICP) Grid, assessed through four methods 1) a document analysis (of a current health policy and available protocols; 2) observation of the infrastructure of health centres, organisation of work, patient flow, interaction of patients with health professionals; 3) interview with key informants and 4) review of medical documentation of selected patients.

The implementation of the integrated care in Slovenia was assessed with the overall ICP score of 3.7 points (out of 5 possible points). The element Identification was almost fully implemented, while the element Self-management support was weakly implemented.

The implementation of the integrated care of patients with diabetes and/or hypertension in Slovenian primary health care organisations achieved high levels of implementation. However, some week points were identified.

Integrated care of the chronic patients in Slovenia is already provided at high levels, but the area of self-management support could be improved.

Integrated care of the chronic patients in Slovenia is already provided at high levels, but the area of self-management support could be improved.

Networks constitute a promising strategy for interorganisational collaboration, but may fail due to network tensions. By investigating the activities and internal dynamics of a voluntary meso-level network operating in the intersection of health and social care, this study aims to enhance the understanding of the relationship between pragmatism and sustainability and the role network governance plays in this respect.

In this descriptive case study, 2-3 researchers observed 3 three-hour long network meetings during the course of a year, and four complementary interviews were performed. Data were analysed based on the literature on network functioning and effectiveness.

Pragmatism (a focus on 'getting things done') was more emphasised than sustainability although the network meetings also contained elements of relationship- and trust-building. The network leadership (a Network Administrative Organisation, NAO) created structure and concretized the participants' ideas while remaining flexible and perceptive, and also carried out tasks which would otherwise not have been performed.

The emphasis on pragmatism did not seem to influence sustainability negatively which has been pointed out as a potential risk in previous literature. Rather, the focus on pragmatism reinforced sustainability in a way that is similar to what has been described in prior research as a "trust-building loop" and discussed further in terms of a "perception of progress" mechanism. However, it was unclear what future the voluntary network would have without the NAO.

Network governance is instrumental to success, and should be carefully considered when initiating interorganisational network initiatives for integrated care.

Network governance is instrumental to success, and should be carefully considered when initiating interorganisational network initiatives for integrated care.Sinusitis or rhinosinusitis is inflammation of the paranasal sinuses which can be due to autoimmune, allergy, and infection problems. Current study was aimed to evaluate the antibiofilm and antibacterial potential of different varieties of A sativum. Four different varieties (China white, China pink, Desi white, and Desi pink) were used and extracted with methanol and water. Results of antioxidant analysis of A sativum extracts showed that all varieties of garlic have considerable quantity of flavonoids with significant DPPH inhibition and reductive potential. Antibacterial activity of A sativum extracts was tested against different Gram negative and Gram-positive sinusitis isolates. All the sinusitis isolates were susceptible to both methanolic and aqueous extracts of different varieties of A sativum with least MIC values. Antibiofilm potential of extracts against sinusitis isolates was evaluated through crystal violet assay, and all extracts of A sativum were significantly effective against destruction of microbial biofilm. In summary, A sativum extracts possess effective antibacterial and antibiofilm activity against sinusitis isolates and can be utilized for prevention of drug resistance against sinusitis infections and further evaluation is necessary.

Previously, we demonstrated that the specific ratio of Korean multi-herbal formula (SR-5) exhibits hepatoprotective properties against ethanol-induced hepatic damage in rats. Chronic and excessive alcohol consumption is a major etiological factor involved in gastric disease and ulcer development induced by the inflammatory response and oxidative stress.

The present study evaluated the gastroprotective effects of SR-5 (100, 150, and 200mg/kg) against hydrochloride acid/ethanol (HCl/EtOH)-induced and indomethacin/hydrochloride acid (INDO/HCl)-induced gastritis in a mouse model and the mechanisms involved.

All the tested doses of SR-5 significantly inhibited gastric lesions in the HCl/EtOH-induced ulcer model mice. Similarly, all the tested doses of SR-5 significantly inhibited gastric lesions in the INDO/HCl-induced ulcer model mice. Furthermore, mice pretreated with SR-5 had significantly increased gastric levels of enzymatic and nonenzymatic antioxidants, namely, catalase (CAT) and glutathione (GSH), with concomitant reductions in malondialdehyde (MDA) and reactive oxygen species (ROS) levels compared with those in the HCl/EtOH or INDO/HCl group. SR-5 suppressed the expression of nuclear factor-kappa B (NF-κB)/p65, inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), and cyclooxygenase-2 (COX-2) to their normal values.

These findings are the first to demonstrate the powerful protective effect of SR-5 against gastric injury development and provide hope for clinical application.

These findings are the first to demonstrate the powerful protective effect of SR-5 against gastric injury development and provide hope for clinical application.Data and information obtained from low-cost uncrewed aerial vehicles (UAVs), commonly referred to as 'drones', can be used to support integrated coastal zone management (ICZM) and sustainable development at the coast. Several recent studies in various disciplines, including ecology, engineering, and several branches of physical and human geography, describe the applications of UAV technology with practical coastal management potential, yet the extent to which such data can contribute to these activities remains underexplored. The main objective of this paper is to collate this knowledge to highlight the areas in which UAV technology can contribute to ICZM and can influence the achievement of the UN Sustainable Development Goals (SDGs) at the coast. We focus on applications with practical potential for coastal management activities and assess their accessibility in terms of cost, ease of use, and maturity. We identified ten (out of the 17) SDGs to which UAVs can contribute data and information. Examples of applications include surveillance of illegal fishing and aquaculture activities, seaweed resource assessments, cost-estimation of post-storm damages, and documentation of natural and cultural heritage sites under threat from, for example, erosion and sea-level rise. GS-4224 PD-1 inhibitor An awareness of how UAVs can contribute to ICZM, as well as the limitations of the technology, can help coastal practitioners to evaluate their options for future management activities.

The online version contains supplementary material available at 10.1007/s12237-021-01001-5.

The online version contains supplementary material available at 10.1007/s12237-021-01001-5.The COVID-19 pandemic imposed a strict state of emergency on Belgrade residents with a curfew and restriction on movement. Therefore, the aim of this study was to determine how the measures introduced as a consequence of this disease in the capital of Serbia affected the duration of walking time of owners and their dogs. The study allowed for sociodemographics of owners, characteristics of their homes and breeds of dog. The research was conducted in the period from March 22 to April 4, 2020. In general, the COVID-19 pandemic restrictions reduced the duration of dog walks and owners' walking time. Of the 216 adult dog owners, 59% walked their dogs successfully (≥150 min/week) before the state of emergency. The number of owners who walked their dogs for ≥150 min/week decreased to only 44% (N=96) during the state of emergency. The pandemic also decreased the number of owners who achieved total walking times of ≥150 min/week, so only 56% of them were successful in total walking time during the state of emergency stics and dog breed) by Fisher's exact test found significant differences only between younger and older dog owners in total walking time during the state of emergency (P less then 0.01). Younger owners were significantly more successful in achieving ≥150 min/week total walking time than owners aged 45-64. The COVID-19 pandemic has left some owners jobless and allowed them to spend more time walking dogs. The occurrence of this disease has led to changes in the social structure of households and in the daily habits of household members. These factors have impacted on the length of walking time of owners and their dogs in Belgrade.In the present study, we report giant extra-ordinary transmission of near infrared (NIR) light, more than 90%, through a seemingly opaque plasmonic metasurface, which consists of two metal nano-slits arrays (MNSAs) with alternate opening arrangements. By using perfect coupling of the plasmonic modes formed between the sharp edges of the upper and lower MNSAs of silver, a giant, wavelength selective transmission could be obtained. The study is accompanied by optimization of electromagnetic (EM) field coupling for different interlayer spacings and lateral overlap between the two MNSAs to understand their significance in light transmission through the metasurface. The interlayer spacing between the MNSAs works as the transmitting channel for light. The optimization of performance with different fill factors and plasmonic metals was performed as well. Because of the excitation of extended surface plasmons (ESPs) generated at both the MNSAs, the metasurface can be used for refractive index (RI) sensing as one of its applications by using a transparent and flexible polymer, such as polydimethylsiloxane (PDMS), as substrate.