Dehnbarber5565

Pain is a public health problem with negative impact on quality of life.

To analyze the prevalence of musculoskeletal pain and associated occupational factors among Pilates instructors, and to compare their quality of life relative to Brazilian reference values.

A total of 166 Pilates instructors from Rio Grande do Sul, Brazil (consecutive sampling) with degrees in physical education or physical therapy responded the 36-Item Short-Form Health Survey and Work-related Habits Questionnaire. Statistical analysis included calculation of prevalence ratios (Poisson regression) and the simple t-test.

About 62% and 63.3% of the participants reported neck and low back pain, respectively. The prevalence of neck (19%) and low back (16%) pain was higher among the participants who reported to feel always stressed regarding psychological pressure. The prevalence of neck pain was 25% higher among the participants who reported to feel always stressed regarding decision making. The prevalence of neck (15%) and low backysical functioning.

The quality of life (QoL) of traffic and transit workers has been a focus of much attention; motorcyclists are the workers most susceptible to accidents and exposure to pollutants. These factors added to smoking might result in respiratory disorders and influence the workers' QoL.

To analyze the QoL of smoking or not motorcycle taxi drivers.

Longitudinal and epidemiological study with quantitative approach conducted with 95 motorcycle taxi drivers from Jatai, southeastern Goias, Brazil, in two stages in 2014 and 2015. We administered a questionnaire to collect sociodemographic and occupational data and self-perceived state of health, and WHOQOL-BREF. Statistical analysis was performed with software Statistical Package for Social Sciences

and STATA

 ; the significance level was set to p<0.05.

Most participants were male (98.9%), nonsmokers (89.5%), had already suffered work accidents (67.4%); their average age was 39.1 years old, and 48.5% described their state of health as good. The score on the physical health domain of QoL decreased (from 86.07 to 74.28; p=0.091) and the one on the environment domain increased (from 58.43 to 64.06; p=0.285) among smokers. Also among nonsmokers the score on domain physical health decreased (from 79.87 to 76.38; p=0.014) and the one on domain environment increased (from 58.27 to 67.32; p<0.001). We found association of age and smoking with QoL domain physical health (p=0.014; 0.027).

Motorcycle taxi drivers are exposed to several factors which might influence their living and working conditions. New public health policies targeting this population of workers are needed.

Motorcycle taxi drivers are exposed to several factors which might influence their living and working conditions. New public health policies targeting this population of workers are needed.

Community health agents (CHA) and endemics combat agents (ECA) play a decisive role in the prevention and control of dengue and are in direct contact with the population.

To analyze the sociodemographic profile, activities and quality of life (QoL) of CHAs and ECAs in two towns in Parana, Brazil, in which dengue is respectively endemic (Paranavai) and epidemic (Paranagua).

Cross-sectional study which analyzed sociodemographic and occupational parameters and the QoL of CHAs and ECAs in July and August 2016.

Ninety-eight health agents were included, 40 from Paranagua and 58 from Paranavai. About 92.9% of the participants were female; their average age was 38.9 years old; 63.5% had completed secondary school; and 90% earned less than 3 times the equivalent of the minimum wage per month. selleck chemicals The agents in Paranagua reported to feel they were better prepared for their job, although most considered training insufficient. Most participants reported to have already suffered verbal violence at work. Job dissatisfaction was higher among the Paranavai agents. QoL analysis showed that neither mental nor physical health was good, which might be explained by sociodemographic factors and professional exhaustion.

Most participants were female, younger adults, with high educational level and low income. The training currently provided to combat dengue is insufficient, as most health agents felt insecure to convey information to the population. A part of the sample had already suffered violence at work. QoL was below the expected level, mainly due to work overload and low salary.

Most participants were female, younger adults, with high educational level and low income. The training currently provided to combat dengue is insufficient, as most health agents felt insecure to convey information to the population. A part of the sample had already suffered violence at work. QoL was below the expected level, mainly due to work overload and low salary.The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one of the targeted approach. Although, designing and developing a panel of new drugs molecules are always encouraged. However, in the current emergency, drug repurposing study is one of the most effective and fast track option. The crystal structure of a SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) RNA Dependent RNA Polymerase (RdRp) has recently been deciphered through X-ray crystallography. The single-chain of core RNA Dependent RNA Polymerase relies on virus-encoded cofactors nsp7 and two units of nsp8 for its optimum function. This study explored the FDA approved database of 7922 molecules and screened against the core polymerase along with cofactors. Here we report a panel of FDA approved drugs that show substantial interactions with key amino acid residues of the active site. Interestingly, some of the identified drugs (Ornipressin, Lypressin, Examorelin, Polymyxin B1) bind strongly within the binding pockets of both forms of RdRp. Besides, we found strong candidates for the complex form as well which include Nacortocin, Cistinexine, Cisatracurium (among others). These drugs have the potential to be considered while contriving therapeutic options.