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17, p<0.0001, I

=98.6%). Egger's test resulted significant at p = 0.009 while Begg's test was not, p = 0.11. Subsequent adjustment via the trim-and-fill method did not predict a new model (studies trimmed=0). Meta-regression analysis found no correlations either between SMD and age (p=0.95) or BMI (p=0.96) but a significant one considering the latitude of the study site as moderator variable (p=0.001).

Among patients with HTs, serum MDA appears to have the greatest potential as non-invasive biomarkers of oxidative stress and endothelial dysfunction (ED).

Among patients with HTs, serum MDA appears to have the greatest potential as non-invasive biomarkers of oxidative stress and endothelial dysfunction (ED).Gefapixant (Lyfnua®; Merck & Co.) is a first-in-class, non-narcotic, selective P2X3 receptor antagonist being developed for the treatment of refractory chronic cough or unexplained chronic cough. Marketing approval for gefapixant is being sought in the EU and USA, and the drug was recently approved for marketing in Japan as treatment for refractory or unexplained chronic cough. This article summarizes the milestones in the development of gefapixant leading to this first approval.Mammalian axon growth has mechanistic similarities with axon regeneration. The growth cone is an important structure that is involved in both processes, and GAP-43 (growth associated protein-43 kDa) is believed to be the classical molecular marker. Previously, we used growth cone phosphoproteomics to demonstrate that S96 and T172 of GAP-43 in rodents are highly phosphorylated sites that are phosphorylated by c-jun N-terminal protein kinase (JNK). We also revealed that phosphorylated (p)S96 and pT172 antibodies recognize growing axons in the developing brain and regenerating axons in adult peripheral nerves. In rodents, S142 is another putative JNK-dependent phosphorylation site that is modified at a lower frequency than S96 and T172. Here, we characterized this site using a pS142-specific antibody. We confirmed that pS142 was detected by co-expressing mouse GAP-43 and JNK1. pS142 antibody labeled growth cones and growing axons in developing mouse neurons. pS142 was sustained until at least nine weeks after birth in mouse brains. The pS142 antibody could detect regenerating axons following sciatic nerve injury in adult mice. Comparison of amino acid sequences indicated that rodent S142 corresponds to human S151, which is predicted to be a substrate of the MAPK family, which includes JNK. Thus, we confirmed that the pS142 antibody recognized human phospho-GAP-43 using activated JNK1, and also that its immunostaining pattern in neurons differentiated from human induced pluripotent cells was similar to those observed in mice. These results indicate that the S142 residue is phosphorylated by JNK1 and that the pS142 antibody is a new candidate molecular marker for axonal growth in both rodents and human.Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with selective degeneration of motor neurons in the central nervous system. The pathophysiology of ALS is not well understood. We have used 1H-[13C]-NMR spectroscopy together with an administration of [1,6-13C2]glucose and [2-13C]acetate in female and male SOD1G37R mice to assess neuronal and astroglial metabolic activity, respectively, in the central nervous system in ALS condition. The female (p = 0.0008) and male (p  less then  0.0001) SOD1G37R mice exhibited decreased forelimb strength when compared with wild-type mice. There was a reduction in N-acetylaspartylglutamate level, and elevation in myo-inositol in the spinal cord of female and male SOD1G37R mice. The transgenic male mice exhibited increased acetate oxidation in the spinal cord (p = 0.05) and cerebral cortex (p = 0.03), while females showed an increase in the spinal cord (p = 0.02) only. As acetate is transported and preferentially metabolized in the astrocytes, the finding of increased rate of acetate oxidation in the transgenic mice is suggestive of astrocytic involvement in the pathogenesis of ALS. The rates of glucose oxidation in glutamatergic (p = 0.0004) and GABAergic neurons (p = 0.0052) were increased in the cerebral cortex of male SOD1G37R mice when compared with the controls. The female mice showed an increase in glutamatergic (p = 0.039) neurometabolic activity only. The neurometabolic activity was unperturbed in the spinal cord of either sex. These data suggest differential changes in neurometabolic activity across the central nervous system in SOD1G37R mice.Brain tumors are the second most common pediatric malignancy and have poor prognosis. Understanding the pathogenesis of tumors at the molecular level is essential for clinical treatment. We conducted a retrospective study on the epidemiology of brain tumors in children based on clinical data obtained from a neurosurgical center. After identifying the most prevalent tumor subtype, we identified new potential diagnostic biomarkers through bioinformatics analysis of the public database. All children (0-15 years) with brain tumors diagnosed histopathologically between 2010 and 2020 at the Department of Neurosurgery, Xijing Hospital, were reviewed retrospectively for age distribution, sex predilection, native location, tumor location, symptoms, and histological grade, and identified the most common tumor subtypes. Two datasets (GSE44971 and GSE44684) were downloaded from the Gene Expression Omnibus database, whereas the GSE44971 dataset was used to screen the differentially expressed genes between normal and tumorhis study, based on the data analysis of intracranial tumors in children in a single center over the past 10 years, reflected the clinical and epidemiological characteristics of intracranial tumors in children in Northwest China to a certain extent. PA is considered the most common subtype of intracranial tumors in children. Through bioinformatics analysis, we suggested that NCKAP1L, GPR37L1, CSPG4, PPFIA4, and C8orf46 are potential biomarkers for the diagnosis of PA.Adolescents' own vocational aspirations and those of parents for their adolescent children play significant roles in adolescents' development. The present study examined how the (in)congruence between adolescents' vocational aspirations and their parents' aspirations for them were associated with adolescents' academic achievement and test anxiety. The study's sample included 662 parent-adolescent pairs (adolescent Mage = 14.09), and the aspiration and adjustment data were collected at intervals 3 years apart. Using polynomial regression analyses and surface graphs, parent-child aspiration congruence was found to be significantly associated with later academic achievement and test anxiety, but incongruence did not show any significant relationship with either outcome. Such patterns were more prominent among boys (n = 306) than girls and among high socioeconomic status (SES) adolescents (n = 324) than among low SES adolescents. The findings suggest that academic adjustment is more predictable when there is parent-child congruence than when there is incongruence in aspirations.It is a common practice to improve the water environment of rivers and lakes in China by the enhancement and releasing (EAR) of silver carp (Hypophthalmichthys molitrix) and bighead carp (Hypophthalmichthys nobilis) for biomanipulation. However, the quantity of bighead carp and its effect on water quality and plankton community have been the focus of debate among ecologists. Herein, in order to more accurately simulate the environmental conditions of lakes, we selected earthen ponds with large areas adjacent to Lake Qiandao from May to August in 2016 to study the responses of water quality condition and plankton community to a gradient of bighead carp stocked alone. Experimental groups with different densities of carp stocked were set as follows 12.1 (LF), 23.5 (MF), and 32.5 g/m3 (HF), and a control group with no fish (NF). Results showed that total phosphorus (TP) in the fish-containing groups considerably decreased, and the lowest chlorophyll-a concentration (chl-a) was detected in the MF group. The biomass accumulation of the crustacean zooplankton was suppressed after carp was introduced, but the diversity, richness, and evenness of the crustacean zooplankton were weakly affected, except in the HF group. Phytoplankton biomass especially that of cyanobacteria was grazed rapidly by fish in the MF and HF groups and biodiversity indices were considerably increased in the fish-containing groups, especially in the late stages of the experiment. At a fish stocking density of 23.5-38.8 g/m3, the highest efficiency in controlling cyanobacteria and promoting water condition was achieved, and the impact on zooplankton diversity was weak. Our results indicated that bighead carp can be included in the EAR of lakes and reservoirs, but the optimal density of bighead carp stocking should be carefully considered.Due to limited groundwater resources in arid and semi-arid areas, conjunctive use of surface water and groundwater is becoming increasingly important. In view of this, there are needs to improve the methods for conjunctive use of surface and groundwater. Using numerical models, optimization algorithms, and machine learning, we created a new comprehensive methodological structure for optimal allocation of surface and groundwater resources and optimal extraction of groundwater. The surface and groundwater system was simulated by MODFLOW to reflect groundwater transport and aquifer conditions. The important Marvdasht aquifer in the south of Iran was used as an experimental study area to test the methodology. In this context, we developed an optimal conjunctive exploitation model for dry and wet years using two new evolutionary algorithms, i.e., whale optimization algorithm (WOA) and firefly algorithm (FA). These were used in combination with the group method of data handling (GMDH) and least squares support vectwater supply problems. The methodology can be used to better estimate sustainable exploitation of groundwater resources by water resources managers.Ceramics-based filter for water treatment is an ancient technology to procure potable water at the household level. The traditional clay pots (vessels or hollow cylindrical container) have been used since long in the developing countries. The ceramic material (CaCu3Ti4O12 or CCTO) is a hetero-junction of titanium oxide, a well-known UV-active photocatalyst, and visible light absorbing CuO materials. This hetero-junction is able to overcome the limitations such as high bandgap, poor stability, low efficiency, and high photo-generated charge (e-/h+) recombination rate, associated with the other commonly used metal oxide semiconductor photocatalysts. Moreover, the low-cost, viable and facile synthesis routes for CCTO triggered its potential applications in photoelectrochemical and photocatalytic processes. This review will elaborate on the available literature demonstrating the visible light activity of CCTO photocatalysts in water treatment technologies. Furthermore, the mechanism of photocatalysis and synthesis routes are presented in this work for broader impact of the CCTO potential applications. The extended porous character and excellent surface texture have made the ceramic materials as an ideal choice to combat the bacteria, pathogens and turbidity in aqueous medium at household level. Specifically, the controlled size and shape make the CaCu3Ti4O12 (CCTO) an excellent visible light-driven photocatalyst, involving highly reactive species such as •OH, •O2- anions, h+, and e-, for the removal of organic and inorganic pollutants from water.