Davidsonkuhn7047

OBJECTIVE The objective of this study was to examine whether osteoarthritis (OA) in the knees was associated with total immunoglobulin E (IgE), allergen-specific IgE, or allergic sensitizations in a nationally representative population. METHODS The study population comprised of 785 adults aged 50 years or more in the Korea National Health and Nutrition Examination Survey 2010. OA was diagnosed as radiographic (rOA) and symptomatic osteoarthritis (sxOA). We performed multivariable logistic regression analyses to investigate relationships of OA in a knee with serum total IgE, allergen (Dermatophagoides farinae, cockroach, and dog allergens)-specific IgE, and allergic sensitizations. RESULTS Participants with the highest tertile of the total IgE had 92% and 242% increased risk of knee rOA and sxOA, respectively. Those with D. farinae-specific IgE had 2.2 times increased risk of knee sxOA compared to the lowest tertile. Participants with high total IgE (>150kU/L) had a 60% increased risk of knee rOA. Those with D. farinae-specific sensitization (>0.35kU/L) had 2.0 times increased risk of knee sxOA in compared to those without sensitization. Population-attributable fractions of knee rOA caused by high total IgE and knee sxOA caused by D. farinae-specific sensitization were 9.8% and 15.3%, respectively. CONCLUSIONS Total IgE and D. farinae-specific IgE were significantly associated with OA in knees of Korean adults. High total IgE and D. farinae-specific sensitization were also associated with their OA. OBJECTIVE To evaluate the short-term effects of use of the dr. Bart app, compared to usual care, on the number of secondary health care consultations and clinical outcomes in people with knee/hip OA in the Netherlands. find more METHOD A randomized controlled design involving participants ≥50 years with self-reported knee and/or hip OA recruited from the community. The number of secondary health care consultations (primary outcome) and secondary outcomes were assessed at baseline, 3 and 6 months via online questionnaires. Data were analyzed using longitudinal mixed models, corrected for baseline values. Due to the design of this study, blinding of participants and researchers was not possible. RESULTS In total, 427 eligible participants were allocated to either the dr. Bart group (n = 214) or usual care (n = 213). We found no difference between groups in the number of secondary (i.e., orthopaedic surgeon, rheumatologist, or physician assistant) health care consultations (incidence rate ratio (IRR) 1.20 (95% CI 0.67; 2.19)). We found positive treatment effects of the dr. Bart app on symptoms (2.6 (95% CI 0.4; 4.9)), pain (3.5 (95% CI 0.9; 6.0)), and activities of daily living (2.9 (95% CI 0.2; 5.6)) on a 0-100 scale, higher score indicating less complaints, but not in any other secondary outcome. CONCLUSION The dr. Bart app did not change the number of secondary health care consultations compared to usual care. However, we found small positive effects (not clinically relevant) on pain, symptoms, and activities of daily living in people with knee/hip OA. TRIAL REGISTRATION Dutch Trial Register (Trial Number NTR6693/NL6505) (https//www.trialregister.nl/trial/6505). OBJECTIVE To describe the association of subchondral and systemic bone mineral density (BMD) with knee and hip replacements (KR and HR, respectively) due to osteoarthritis. DESIGN 1,095 participants (mean age 63 years, 51% female) were included. At baseline, subchondral BMD of the medial and lateral tibia in three regions of interest (ROI) for the right knee, and systemic BMD of the lumbar spine, femoral neck, total hip and whole-body, were measured using dual-energy X-ray absorptiometry. Subchondral BMD of the hip was not measured. Competing risk regression models were used to estimate sub-distribution hazard ratios (SHRs) of KR/HR per one standard deviation (SD) higher in BMD measures, with adjustment of potential confounders. RESULTS Over 12.2 years, 79 (7.2%) participants underwent a KR and 56 (5.1%) an HR due to osteoarthritis. For the right side, medial subchondral BMD in ROI-3 was associated with an increased risk of KR (SHR 1.95 per SD; 95% Confidence Interval [CI], 1.57 to 2.43). In contrast, systemic BMD was not associated with the risk of KR, but higher BMD at the lumbar spine (1.42, 1.07 to 1.88) and whole-body (1.29, 1.00 to 1.66) were associated with an increased risk of HR at both sides. CONCLUSIONS Subchondral BMD is positively associated with an increased risk of KR and systemic BMD with an increased risk of HR, suggesting a role of BMD in the progression of osteoarthritis. BCR-ABL negative myeloproliferative neoplasms (MPN) in transformation have a dismal prognosis, and allogeneic transplantation is thought to be the only curative therapeutic option. We retrospectively analyzed 53 molecularly annotated patients treated at Saint Louis Hospital (France), diagnosed between 2008 and 2018 with MPN in transformation. Median age was 65 years and median interval between MPN diagnosis and MPN transformation was 46 months. Median overall survival (OS) of the entire cohort after transformation was 7.1 months. Overall survival (OS) was better for patients treated by hypomethylating agents or by chemotherapy than those treated by best supportive care or single agent targeted therapy 9.1 vs 1.5 months, p less then 0.001. Patients treated by chemotherapy achieved more often complete remission than those treated by hypomethylating agents (68% vs 29%, p = 0.02), and could be transplanted more frequently (59% vs 14%, p = 0.02) but their median OS was similar. We then compared the outcome of transplanted vs. non-transplanted patients using Mantel-Byar's methodology and demonstrated that allogeneic transplantation did not improve survival. In multivariate analysis, independent prognosis factor of survival were Performance status at transformation (p less then 0.01), initial treatment by hypomethylating agents or by chemotherapy (p = 0.02), and the ability to achieve complete remission during the follow-up (p less then 0.01). In conclusion, indication of transplantation for high-risk MPN should be discussed before transformation since transplantation rescued few patients after transformation.