Daugaardsanchez1561

Van der Waals heterostructures composed of transition-metal dichalcogenide (TMD) materials have become a remarkable compact system that could offer an innovative architecture for advanced engineering in high-performance energy-harvesting and optoelectronic devices. Here, we report a novel van der Waals (vdW) TMD heterojunction photodiode composed of black phosphorus (p-BP) and palladium diselenide (n-PdSe2), which establish a high and tunable rectification and photoresponsivity. A high rectification up to ≈7.1 × 105 is achieved, which is successfully tuned by employing the back-gate voltage to the heterostructure devices. RO4929097 price Besides, the device significantly shows the high and gate-controlled photoresponsivity of R = 9.6 × 105, 4.53 × 105 and 1.63 × 105 A W-1 under the influence of light of different wavelengths (λ = 532, 1064, and 1310 nm) in visible and near-infrared regions, respectively, because of interlayer optical transition and low Schottky. The device also demonstrates extraordinary values of detectivity (D = 5.8 × 1013 Jones) and external quantum efficiency (EQE ≈ 9.4 × 106), which are an order of magnitude higher than the currently reported values. The effective enhancement of photovoltaic characteristics in visible and infrared regions of this TMD heterostructure-based system has a huge potential in the field of optoelectronics to realize high-performance infrared photodetectors.The targeted nanoagents have shown great potential clinically for cancer therapy. Traditional targeted nanodrugs are usually prepared through surface postmodification. Herein, a nanodrug is self-assembled from the amphiphilic precursor of targeting peptide RGD conjugated with cytotoxin epothilone B (Epo B) through a linker containing the thioketal (tk) group that is sensitive to reactive oxygen species (ROS). The obtained RGD-tk-Epo B conjugate nanoparticles (RECNs) are stable and uniform, which facilitates improving tumor-targeting capacity and accumulation of the drug because of the large number of RGD on the surface of the RECN. After internalization by cancer cells, the blood-inert tk group between RGD and Epo B can be cleaved in the presence of high level of ROS to release Epo B, exhibiting a markedly tumor selectivity and excellent anticancer efficiency in vitro and in vivo.Exploring cost-effective and general approaches for highly active and stable bifunctional transition metal phosphide (TMP) electrocatalysts towards overall water splitting is greatly desirable and challenging. Herein, a general strategy combining sol-gel and a carbonization-assisted route was proposed to facilely fabricate a series of TMP nanoparticles, including CoP, MoP, FeP, Cu2P, Ni2P, PtP2, FeNiP, CoNiP, and FeCoNiP, coupled in an amorphous carbon matrix with one-step carbon composite formation. The resultant NiFeP@C exhibits excellent activities as a bifunctional electrocatalyst toward oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) with low overpotentials of 260 and 160 mV, respectively, at 10 mA/cm2 in 1 M KOH solution. With the NiFeP@C electrocatalyst as both electrode materials, an integrated electrolyzer can deliver 47.0 mA/cm2 of current density at 1.60 V, better than the assembled Pt/C20∥IrO2 counterpart. The encapsulation of NiFeP nanoparticles in the carbon matrix effectively prevents their corrosion and leads to almost unfading catalytic activities for more than 20 h for either the HER, OER, or overall water splitting, outperforming recently reported bifunctional electrocatalysts. The coexistence of Ni, Fe, P, and C would have synergetic effects to accelerate charge transfer and promote electrocatalytic activity. This universal strategy for TMP-based composites opens up a new avenue to explore TMPs as multifunctional materials for various applications.in English, Spanish Introducción la apoplejía hipofisaria es un síndrome clínico que refleja la existencia de una rápida expansión del contenido selar, comúnmente tributario a un infarto hemorrágico o isquémico en un adenoma hipofisario previo. Esta patología es una complicación poco común y, por lo tanto, infradiagnosticada. Las consecuencias de un retraso en el diagnóstico se traducen en complicaciones funcionales graves e incluso mortales para el paciente. Caso clínico se presenta el caso de un paciente hombre de 42 años, el cual inició su padecimiento con un cuadro clínico difuso, caracterizado por cefalea, ambliopía y alteraciones de la conciencia. El diagnóstico se resolvió como apoplejía hipofisaria e hipopituitarismo secundario, cuyo tratamiento se hizo de manera conservadora, con antiinflamatorios esteroideos y sustitución hormonal. El paciente presentó un episodio psicótico inducido por esteroides, esto a causa de las dosis suprafisiológicas utilizadas necesarias para revertir el daño neurológico existente; sin embargo, finalizó en una restitución funcional ad integrum a los 15 días postratamiento médico, sin requerir intervención neuroquirúrgica. Conclusiones el caso clínico presentado y su resolución son evidencia clara de la importancia de un diagnóstico oportuno y adecuado, ya que de ser detectado en etapas tempranas y tratado precozmente, de acuerdo con la evolución de la patología, no siempre requerirá intervención quirúrgica, lo cual permitirá una restitución neurológica total.in English, Spanish Introducción la diabetes del adulto de inicio juvenil (MODY, por sus siglas en inglés maturity onset diabetes of the young) es un tipo de diabetes que resulta de mutaciones en 13 genes conocidos que desempeñan un papel en el desarrollo y la maduración de las células beta pancreáticas. Representa el 5% de todas las personas diagnosticadas con diabetes antes de los 45 años y se diagnostica erróneamente como diabetes tipo 1 o tipo 2 hasta en el 80% de los casos. Caso clínico presentamos el caso de una mujer de 21 años, inicialmente diagnosticada con diabetes tipo 1 a los 19 años y con descontrol glucémico a pesar del uso adecuado de insulina de acción prolongada. Tenía antecedentes familiares de diabetes y glucosuria persistente. Debido a la alta sospecha de diabetes MODY, solicitamos una prueba oral de tolerancia a la glucosa (basal 130 mg/dL y dos horas después de la carga de glucosa 240 mg/dL) y de concentraciones séricas de péptido C (1.83 ng/mL), que confirmaron el diagnóstico. La paciente mejoró después del tratamiento con sulfonilurea y se logró la interrupción del tratamiento con insulina.