Dammchandler6013

Egocentric activity recognition in first-person video (FPV) requires fine-grained matching of the camera wearer's action and the objects being operated. The traditional method used for third-person action recognition does not suffice because of (1) the background ego-noise introduced by the unstructured movement of the wearable devices caused by body movement; (2) the small-sized and fine-grained objects with single scale in FPV. Size compensation is performed to augment the data. It generates a multi-scale set of regions, including multi-size objects, leading to superior performance. We compensate for the optical flow to eliminate the camera noise in motion. We developed a novel two-stream convolutional neural network-recurrent attention neural network (CNN-RAN) architecture spatial temporal attention on compensation information (STAC), able to generate generic descriptors under weak supervision and focus on the locations of activated objects and the capture of effective motion. We encode the RGB features using a spatial location-aware attention mechanism to guide the representation of visual features. Similar location-aware channel attention is applied to the temporal stream in the form of stacked optical flow to implicitly select the relevant frames and pay attention to where the action occurs. The two streams are complementary since one is object-centric and the other focuses on the motion. We conducted extensive ablation analysis to validate the complementarity and effectiveness of our STAC model qualitatively and quantitatively. It achieved state-of-the-art performance on two egocentric datasets.Brassinin is a phytochemical derived from Chinese cabbage, a cruciferous vegetable. Brassinin has shown anticancer effects on prostate and colon cancer cells, among others. However, its mechanisms and effects on hepatocellular carcinoma (HCC) have not been elucidated yet. Our results confirmed that brassinin exerted antiproliferative effects by reducing proliferating cell nuclear antigen (PCNA) activity, a proliferation indicator and inducing cell cycle arrest in human HCC (Huh7 and Hep3B) cells. Brassinin also increased mitochondrial Ca2+ levels and depolarized the mitochondrial membrane in both Huh7 and Hep3B cells. Moreover, brassinin generated high amounts of reactive oxygen species (ROS) in both cell lines. The ROS scavenger N-acetyl-L-cysteine (NAC) inhibited this brassinin-induced ROS production. Brassinin also regulated the AKT and mitogen-activated protein kinases (MAPK) signaling pathways in Huh7 and Hep3B cells. Furthermore, co-administering brassinin and pharmacological inhibitors for JNK, ERK1/2 and P38 decreased cell proliferation in both HCC cell lines more than the pharmacological inhibitors alone. Collectively, our results demonstrated that brassinin exerts antiproliferative effects via mitochondrial dysfunction and MAPK pathway regulation on HCC cells.Trichothecenes are the most prevalent mycotoxins contaminating cereal grains. Some of them are also considered as the virulence factors of Fusarium head blight disease. However, the mechanism behind the structure-activity relationship for trichothecenes remains unexplained. Filling this information gap is a crucial step for developing strategies to manage this large family of mycotoxins in food and feed. Here, we perform an in-depth re-examination of the existing structures of Saccharomyces cerevisiae ribosome complexed with three different trichothecenes. Multiple binding interactions between trichothecenes and 25S rRNA, including hydrogen bonds, nonpolar pi stacking interactions and metal ion coordination interactions, are identified as important binding determinants. These interactions are mainly contributed by the key structural elements to the toxicity of trichothecenes, including the oxygen in the 12,13-epoxide ring and a double bond between C9 and C10. In addition, the C3-OH group also participates in binding. The comparison of three trichothecenes binding to the ribosome, along with their binding pocket architecture, suggests that the substitutions at different positions impact trichothecenes binding in two different patterns. Moreover, the binding of trichothecenes induced conformation changes of several nucleotide bases in 25S rRNA. This then provides a structural framework for understanding the structure-activity relationships apparent in trichothecenes. This study will facilitate the development of strategies aimed at detoxifying mycotoxins in food and feed and at improving the resistance of cereal crops to Fusarium fungal diseases.Diesel acts as a main energy source to complement human activities in Antarctica. However, the increased expedition in Antarctica has threatened the environment as well as its living organisms. While more efforts on the use of renewable energy are being done, most activities in Antarctica still depend heavily on the use of diesel. Diesel contaminants in their natural state are known to be persistent, complex and toxic. The low temperature in Antarctica worsens these issues, making pollutants more significantly toxic to their environment and indigenous organisms. A bibliometric analysis had demonstrated a gradual increase in the number of studies on the microbial hydrocarbon remediation in Antarctica over the year. It was also found that these studies were dominated by those that used bacteria as remediating agents, whereas very little focus was given on fungi and microalgae. This review presents a summary of the collective and past understanding to the current findings of Antarctic microbial enzymatic degradation of hydrocarbons as well as its genotypic adaptation to the extreme low temperature.Solution-processed organometal halide perovskites (OMHPs) have been widely used in optoelectronic devices, and have exhibited brilliant performance. One of their generally recognized advantages is their easy fabrication procedure. VTP50469 However, such a procedure also brings uncertainty about the opto-electric properties of the final samples and devices, including morphology, stability, coverage ratio, and defect concentration. Normally, one needs to find a balanced condition, because there is a competitive relation between these parameters. In this work, we fabricated CH3NH3PbI3 films by carefully changing the ratio of the PbI2 to CH3NH3I, and found that the stoichiometric and solvent engineering not only determined the photoluminescence efficiency and defects in the materials, but also affected the photostability, morphology, and coverage ratio. Combining solvent engineering and the substitution of PbI2 by Pb(Ac)2, we obtained an optimized fabrication condition, providing uniform CH3NH3PbI3 films with both high photoluminescence efficiency and high photostability under either I-rich or Pb-rich conditions. These results provide an optimized fabrication procedure for CH3NH3PbI3 and other OMHP films, which is crucial for the performance of perovskite-based solar cells and light emitting devices.Background Sexually transmitted gonorrhea, caused by the Gram-negative diplococcus Neisseria gonorrhoeae, continues to be a serious global health challenge despite efforts to eradicate it. Multidrug resistance among clinical N. gonorrhoeae isolates has limited treatment options, and attempts to develop vaccines have not been successful. Methods A search of published literature was conducted, and information extracted to provide an update on the status of therapeutics and vaccine development for gonorrheal infection. Results Recommended pharmacological treatment for gonorrhea has changed multiple times due to increasing acquisition of resistance to existing antibiotics by N. gonorrhoeae. Only broad-spectrum cephalosporin-based combination therapies are currently recommended for treatment of uncomplicated urogenital and anorectal gonococcal infections. With the reported emergence of ceftriaxone resistance, successful strategies addressing the global burden of gonorrhea must include vaccination. Century-old efforts at developing an effective vaccine against gonorrhea, leading to only four clinical trials, have not yielded any successful vaccine. Conclusions While it is important to continue to explore new drugs for the treatment of gonorrhea, the historical trend of resistance acquisition suggests that any long-term strategy should include vaccine development. Advanced technologies in proteomics and in silico approaches to vaccine target identification may provide templates for future success.The extraordinary features of fibrous composites enable advanced industries to design composite structures with superior performance compared to traditional structures. Composite frame structures have been designed frequently as components of mechanical systems to resist lateral and gravity loads. The manufacturing of high-quality composite frames depends primarily on the accurate fiber winding on frames with different pro-files and curved shapes. The optimal fiber winding process on a nonbearing composite frame with a circular cross-section is described in previous works by the same authors. As an extension to that, this study focuses on the manufacturing of straight-line composite frames with different profile radii at multiple locations. Such production procedure allows continuous winding of fibers gradually on individual parts of the frame and generally with different angles of fiber winding. The winding procedure is performed using fiber-processing head and industrial robot. The procedure for calculating the distance of the winding plane of fibers on the frame from the guide-line of the fiber-processing head is targeted. This distance depends on the required angle of fiber winding, the radius of the frame, and the geometric parameters of the fiber-processing head. The coordination of the speed of winding the fibers on the frame and the speed of the passage of the frame through the winding head is also considered. Determining the correct distance of winding the fibers from the corresponding guide-line of fiber-processing head and right coordination of the winding speed and the speed of passage of the frame through the fiber-processing head ensure compliance of the required angles of fiber windings on the frame and homogeneity of winding fibers, which are the two of the most important prerequisites for producing a quality composite frame. The derived theory is well verified on a practical experimental example.Positron emission tomography (PET) is one of the commonly used scanning techniques. Medical staff manually calculate the estimated scan time for each PET device. However, the number of PET scanning devices is small, the number of patients is large, and there are many changes including rescanning requirements, which makes it very error-prone, puts pressure on staff, and causes trouble for patients and their families. Although previous studies proposed algorithms for specific inspections, there is currently no research on improving the PET process. This paper proposes a real-time automatic scheduling and control system for PET patients with wearable sensors. The system can automatically schedule, estimate and instantly update the time of various tasks, and automatically allocate beds and announce schedule information in real time. We implemented this system, collected time data of 200 actual patients, and put these data into the implementation program for simulation and comparison. The average time difference between manual and automatic scheduling was 7.