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Laparoscopic cholecystectomy is one of the most frequently performed interventions in general surgery departments. Some of the most important aims in achieving perioperative stability in these patients is diminishing the impact of general anesthesia on the hemodynamic stability and the optimization of anesthetic drug doses based on the individual clinical profile of each patient. The objective of this study is the evaluation of the impact, as monitored through entropy (both state entropy (SE) and response entropy (RE)), that the depth of anesthesia has on the hemodynamic stability, as well as the doses of volatile anesthetic. A prospective, observational, randomized, and monocentric study was carried out between January and December 2019 in the Clinic of Anesthesia and Intensive Care of the "Pius Brînzeu" Emergency County Hospital in Timișoara, Romania. The patients included in the study were divided in two study groups patients in Group A (target group) received multimodal monitoring, which included monitori of anesthesia (SE and RE) led to a considerable improvement in perioperative hemodynamic stability. Furthermore, optimizing the doses of anesthetic drugs based on the individual clinical profile of each patient led to a considerable decrease in drug consumption, as well as to a lower incidence of hemodynamic side-effects.The objective of this study was to verify the feasibility of mouse data exposure by deriving features to improve the accuracy of a mouse data attack technique using machine learning models. To improve the accuracy, the feature appearing between the mouse coordinates input from the user was analyzed, which is defined as a feature for machine learning models to derive a method of improving the accuracy. As a result, we found a feature where the distance between the coordinates is concentrated in a specific range. We verified that the mouse data is apt to being stolen more accurately when the distance is used as a feature. An accuracy of over 99% was achieved, which means that the proposed method almost completely classifies the mouse data input from the user and the mouse data generated by the defender.This paper investigated the behavior of the two-dimensional magnetohydrodynamics (MHD) nanofluid flow of water-based suspended carbon nanotubes (CNTs) with entropy generation and nonlinear thermal radiation in a Darcy-Forchheimer porous medium over a moving horizontal thin needle. The study also incorporated the effects of Hall current, magnetohydrodynamics, and viscous dissipation on dust particles. The said flow model was described using high order partial differential equations. An appropriate set of transformations was used to reduce the order of these equations. The reduced system was then solved by using a MATLAB tool bvp4c. The results obtained were compared with the existing literature, and excellent harmony was achieved in this regard. The results were presented using graphs and tables with coherent discussion. It was comprehended that Hall current parameter intensified the velocity profiles for both CNTs. Furthermore, it was perceived that the Bejan number boosted for higher values of Darcy-Forchheimer number.The overall shape features that emerge from combinations of shape elements, such as "complexity" and "order", are important in designing shapes of industrial products. However, controlling the features of shapes is difficult and depends on the experience and intuition of designers. Among these features, "complexity" is said to have an influence on the "beauty" and "preference" of shapes. This research proposed a Gaussian curvature entropy as a "complexity" index of a curved surface shape. The proposed index is calculated based on Gaussian curvature, which is obtained by the sampling and quantization of a curved surface shape and validated by the sensory evaluation experiment while using two types of sample shapes. The result indicates the correspondence of the index to perceived "complexity" (the determination coefficient is greater than 0.8). Additionally, this research constructed a shape generation method that was based on the index as a car design supporting apparatus, in which the designers can refer many shapes generated by controlling "complexity". JNJ-26481585 The applicability of the proposed method was confirmed by the experiment while using the generated shapes.A stable explicit difference scheme, which is based on forward Euler format, is proposed for the Richards equation. To avoid the degeneracy of the Richards equation, we add a perturbation to the functional coefficient of the parabolic term. In addition, we introduce an extra term in the difference scheme which is used to relax the time step restriction for improving the stability condition. With the augmented terms, we prove the stability using the induction method. Numerical experiments show the validity and the accuracy of the scheme, along with its efficiency.Background A common task in machine learning is clustering data into different groups based on similarities. Clustering methods can be divided in two groups linear and nonlinear. A commonly used linear clustering method is K-means. Its extension, kernel K-means, is a non-linear technique that utilizes a kernel function to project the data to a higher dimensional space. The projected data will then be clustered in different groups. Different kernels do not perform similarly when they are applied to different datasets. Methods A kernel function might be relevant for one application but perform poorly to project data for another application. In turn choosing the right kernel for an arbitrary dataset is a challenging task. To address this challenge, a potential approach is aggregating the clustering results to obtain an impartial clustering result regardless of the selected kernel function. To this end, the main challenge is how to aggregate the clustering results. A potential solution is to combine the clustering results using a weight function. In this work, we introduce Weighted Mutual Information (WMI) for calculating the weights for different clustering methods based on their performance to combine the results. The performance of each method is evaluated using a training set with known labels. Results We applied the proposed Weighted Mutual Information to four data sets that cannot be linearly separated. We also tested the method in different noise conditions. Conclusions Our results show that the proposed Weighted Mutual Information method is impartial, does not rely on a single kernel, and performs better than each individual kernel specially in high noise.

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