Damborgguldager2007

y marker of interest. A larger randomized controlled trial aimed at measuring both biological and clinical outcomes is indicated. Clinical Trial Registration ClinicalTrials.gov, Identifier NCT02723344.Background Injuries from exposure to explosions rose dramatically during the Iraq and Afghanistan wars, which motivated investigation of blast-related neurotrauma. We have undertaken human studies involving military "breachers" -exposed to controlled, low-level blast during a 3-days explosive breaching course. Methods We screened epigenetic profiles in peripheral blood samples from 59 subjects (in two separate U.S. Military training sessions) using Infinium MethylationEPIC BeadChips. Participants had varying numbers of exposures to blast over their military careers (empirically defined as high ≥ 40, and conversely, low less then 39 breaching exposures). Daily self-reported physiological symptoms were recorded. Tinnitus, memory problems, headaches, and sleep disturbances are most frequently reported. Results We identified 14 significantly differentially methylated regions (DMRs) within genes associated with cumulative blast exposure in participants with high relative to low cumulative blast exposure. Notablyculties, and those within FMOD and TNXB track with pain and headache. Conclusion Sleep disturbances, as well as tinnitus and chronic pain, are widely reported in U.S. military service members and veterans. As we have previously demonstrated, DNA methylation encapsulates lifetime exposure to blast. The current data support previous findings and recapitulate transcriptional regulatory alterations in genes involved in sleep, auditory function, and pain. These data uncovered novel epigenetic and transcriptional regulatory mechanism underlying the etiological basis of these symptoms.A stroke prediction model based on the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project was developed. We compared its predictive ability with the revised Framingham Stroke Risk Score (R-FSRS) for 5-year stroke incidence in a community cohort of Chinese adults, namely the Beijing Longitudinal Study of Aging (BLSA). Calibration, discrimination, and recalibration were used to compare the predictive ability between the two prediction models. Category-less net reclassification improvement (NRI) and integrated discrimination improvement (IDI) values were also assessed. During a mean follow-up duration of 5.1 years, 106 incidents of fatal or non-fatal strokes occurred among 1,203 participants aged 55-84 years. The R-FSRS applied to our cohort underestimated the 5-year risk for stroke in men and women. China-PAR performed better than the R-FSRS in terms of calibration (men, R-FSRS χ2-value 144.2 [P less then 0.001], China-PAR 10.4 [P = 0.238]; women, R-FSRS 280.1 [P less then 0.001], China-PAR 12.5 [P = 0.129]). In terms of discrimination, R-FSRS and China-PAR models performed modestly in our cohort (C-statistic 0.603 [95% CI 0.560-0.644] for men using China-PAR and 0.568 [95% CI 0.524-0.610] using the R-FSRS; the corresponding numbers for women were 0.602 [95% CI 0.564-0.639] and 0.575 [95% CI 0.537-0.613). The recalibrated China-PAR model significantly improved the discrimination in C statistics and produced higher category-less NRI and IDI for stroke incidence than the R-FSRS. Although China-PAR fairly estimated stroke risk in our cohort, it did not sufficiently identify adults at high risk of stroke. Caution would be exercised by practitioners in applying the original China-PAR to Chinese older adults. Further studies are needed to develop an adequate prediction model based on the recalibrated China-PAR or to find new risk markers which could upgrade this model.[This corrects the article DOI 10.3389/fpsyg.2020.01975.].[This corrects the article DOI 10.3389/fpsyg.2020.588604.].[This corrects the article DOI 10.3389/fpsyg.2019.02611.].

Besides the evident positive effect on body development, physical activity has proven to boost executive functions, especially if the exercises are enriched with cognitive stimuli. Previous studies have shown that introducing challenging exercises in the physical activity routine can also enhance motivation. Therefore, enriching a physical education program with cognitively challenging exercises may also foster children's motivation during physical education classes, where the motivation is high at the beginning of the school year and low at the end of it. Therefore, the purpose of this paper is to test if a sport program enriched by cognitive stimuli may improve kids' motivation or take them out from a state of amotivation along the school year.

A sample of 342 school children (203 boys, 139 girls) took part in the study. Participants were asked to complete a battery of motivation and perceived social support questionnaires before and after they completed the ESA Program, a sport program enriched with cognitive stimuli. Moreover, parents of these children attended four seminars about the importance of supporting children for the practice of regular physical activity (PA). Selleckchem MK-0991 A control group consisting of children that attended the ordinary physical education school class was also included.

A repeated measures MANOVA model showed that the ESA Program was able to improve children's general motivation, in particular the intrinsic motivation. The program was not effective in social support, but, independently from the group, the family social support in sports activities decreased for females.

Apart from cognitive improvement, the ESA Program can have beneficial effects on children's sports motivation in physical education, but not on perceived social support.

Apart from cognitive improvement, the ESA Program can have beneficial effects on children's sports motivation in physical education, but not on perceived social support.Introduction The impulsivity, sensation-seeking, and drug use variables, in addition to being closely related, have repercussions on peer conflict and violence in schools. Objective The purpose of this study was to analyze the relationship between impulsivity, sensation-seeking, and drug use in aggressors and victims of violence. Methods The study design was cross-sectional and observational. The study sample was made up of 822 students aged 13-18 who had completed an ad hoc questionnaire, the State Impulsivity Scale and the Sensation-Seeking Scale. Results The results showed that the aggressors had high levels of gratification, automatism, attentional factor, disinhibition, and susceptibility to boredom and used alcohol and/or tobacco. Conclusion The design of an effective education intervention for reducing risk behaviors related to violence must focus on these variables.