Dallpurcell5549

001).

CADOn three-unit posterior FDPs demonstrate excellent fracture resistance after 5 years of clinical function. All evaluated clinical parameters were satisfactory, except for surface stain, which also increased over time.

Conventionally veneered bi-layer zirconia-based posterior FDPs have limited clinical success. Based on this study, alternative methods such as zirconia frameworks veneered with milled lithium disilicate glass-ceramic provide a viable alternative with excellent long-term clinical outcomes.

Conventionally veneered bi-layer zirconia-based posterior FDPs have limited clinical success. Based on this study, alternative methods such as zirconia frameworks veneered with milled lithium disilicate glass-ceramic provide a viable alternative with excellent long-term clinical outcomes.Obesity is associated with hypothalamic-pituitary-testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field.Long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been studied in multiple diseases, but the role of HOTAIR on chronic heart failure (CHF) through the regulation of microRNA (miR)-30a-5p and lysine-specific demethylase 3A (KDM3A) remains unexplored. This research aims to probe the effects of HOTAIR on CHF progression via modulating miR-30a-5p to target KDM3A. CHF mouse model was established by intraperitoneal injection of doxorubicin. The CHF mice were then injected with high-expressed HOTAIR, miR-30a-5p or KDM3A adenovirus vectors to determine the cardiac function, oxidative stress, inflammatory response, pathological change and cardiomyocyte apoptosis. HOTAIR, miR-30a-5p, KDM3A and Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) expression in CHF mice was detected. The binding relations among HOTAIR, miR-30a-5p and KDM3A were validated. HOTAIR and KDM3A were depleted, while miR-30a-5p was augmented in CHF mice. The elevated HOTAIR or KDM3A or could improve cardiac function, mitigate oxidative stress and pathological change, reduce inflammatory factor levels and cardiomyocyte apoptosis, while the increased miR-30a-5p exerted opposite effects. The miR-30a-5p elevation could reverse the effects of enriched HOTAIR, while BNIP3 reduction abrogated the effects of KDM3A on CHF. HOTAIR sponged miR-30a-5p that targeted KDM3A. HOTAIR improves cardiac injury in CHF via modulating miR-30a-5p to target KDM3A. This study provides novel therapeutic strategies for CHF treatment.

Mouthguard thickness influences the protection ability from orofacial trauma. The aim of this study was to propose a new design for mouthguards and to evaluate the effect of the lamination order on the thicknesses of mouthguards.

Mouthguard sheets of 2.0-mm and 4.0-mm ethylene vinyl acetate were used. The sheets were pressure formed using a pressure former. Two lamination conditions were examined The condition 24P used the 2.0-mm sheet as the first layer and 4.0-mm sheet as the second layer. The condition 42P used the 4.0-mm sheet as the first layer and 2.0-mm sheet as the second layer. The first layer was trimmed to cover only the anterior region, and then the second layer was formed over the first layer. Mouthguard thickness was measured using a measuring device at the labial surface of the central incisor, plus the buccal and occlusal surfaces of the first molar. Differences in thickness by measurement region of mouthguards formed under different lamination conditions were analyzed by two-way analysis of variance.

Mouthguard thickness differed among the regions at the central incisors and the first molars (p<.01). The thickness at the labial surface of the central incisor became statistically significantly larger with the 42P condition (3.38mm) than with the 24P condition (3.30mm) (p<.05). The thickness at the buccal and occlusal surfaces of the first molar became statistically significantly larger with the 24P condition (2.25mm and 2.72mm, respectively) than with the 42P condition (1.23mm and 1.44mm, respectively) (p<.01).

The results suggest that the combination of the 2.0-mm and 4.0-mm sheets could obtain the necessary thickness for the prevention at the labial surface of the central incisor and buccal surface of the first molar.

The results suggest that the combination of the 2.0-mm and 4.0-mm sheets could obtain the necessary thickness for the prevention at the labial surface of the central incisor and buccal surface of the first molar.The first-line treatment of advanced and metastatic human epidermal growth factor receptor type 2 (HER2+) breast cancer requires two HER2-targeting antibodies (trastuzumab and pertuzumab) and a taxane (docetaxel or paclitaxel). The three-drug regimen costs over $320,000 per treatment course, requires a 4 h infusion time, and has many adverse side effects, while achieving only 18 months of progression-free survival. To replace this regimen, reduce infusion time, and enhance efficacy, a single therapeutic is developed based on trastuzumab-conjugated nanoparticles for co-delivering docetaxel and siRNA against HER2 (siHER2). The optimal nanoconstruct has a hydrodynamic size of 100 nm and specifically treats HER2+ breast cancer cells over organ-derived normal cells. In a drug-resistant orthotopic HER2+ HCC1954 tumor mouse model, the nanoconstruct inhibits tumor growth more effectively than the docetaxel and trastuzumab combination. When coupled with microbubble-assisted focused ultrasound that transiently disrupts the blood brain barrier, the nanoconstruct inhibits the growth of trastuzumab-resistant HER2+ BT474 tumors residing in the brains of mice. The nanoconstruct has a favorable safety profile in cells and in mice. Combination therapies have become the cornerstone of cancer treatment and this versatile nanoparticle platform can co-deliver multiple therapeutic types to ensure that they reach the target cells at the same time to realize their synergy.2D materials with intriguing properties have been widely used in optoelectronics. However, electronic devices suffered from structural damage due to the ultrathin materials and uncontrolled defects at interfaces upon metallization, which hindered the development of reliable devices. Here, a damage-free Au/h-BN/Au memristor is reported using a clean, water-assisted metal transfer approach by physically assembling Au electrodes onto the layered h-BN which minimized the structural damage and undesired interfacial defects. The memristors demonstrate significantly improved performance with the coexistence of nonpolar and threshold switching as well as tunable current levels by controlling the compliance current, compared with devices with evaporated contacts. The devices integrated into an array show suppressed sneak path current and can work as both logic gates and latches to implement logic operations allowing in-memory computing. Cross-sectional scanning transmission electron microscopy analysis validates the feasibility of this nondestructive metal integration approach, the crucial role of high-quality atomically sharp interface in resistive switching, and a direct observation of percolation path. The underlying mechanism of boron vacancies-assisted transport is further supported experimentally by conductive atomic force microscopy free from process-induced damage, and theoretically by ab initio simulations.This work reports the dehydrated Zr-based MOF UiO-66(SH)2 as a visible-light-driven photocatalyst to mimic the biological N2 fixation process. The 15 N2 and other control experiments demonstrated that the new photocatalyst is highly efficient in converting N2 to ammonia. In-situ TGA, XPS, and EXAFS as well as first-principles simulations were used to demonstrate the role of the thermal treatment and the changes of the local structures around Zr due to the dehydration. It was shown that the dehydration opened a gate for the entry of N2 molecules into the [Zr6 O6 ] cluster where the strong N≡N bond was broken stepwise by μ-N-Zr type interactions driven by the photoelectrons aided by the protonation. This mechanism was discussed in comparison with the Lowe-Thorneley mechanism proposed for the MoFe nitrogenase, and with emphasis on the [Zr6 O6 ] cluster effect and the leading role of photoelectrons over the protonation. The results shed new light on understanding the catalytic mechanism of biological N2 fixation and open a new way to fix N2 under mild conditions.

To date, there is a controversy regarding the effects of acute aerobic exercise of moderate intensity on executive function and prefrontal cortex activity in community-dwelling older adults. This study aimed to investigate the effects of acute aerobic exercise of moderate intensity in healthy older adults.

Fifty-six healthy older adults were randomly assigned to the experimental group (EG) that performed moderate-intensity aerobic exercise or the wait-list control group (CG) for a total of 15 sessions. To compare the two groups, the Stroop Color-Word Task (SCWT) and the Trail-Making Test Part B (TMT-B) were implemented for executive function and prefrontal cortex activity during executive function testing.

After the intervention, the EG achieved a significant improvement in the SCWT (P< 0.001; η

= 0.196) and the TMT-B (P< 0.001; η

= 0.245) compared with the CG. In addition, the EG showed a lower HbO2 concentration in the prefrontal cortex than the CG during the SCWT (P< 0.05; η

= 0.076) and the TMT-B (P< 0.05; η

= 0.090).

These findings shed new light on the clinical effectiveness of acute moderate-intensity aerobic exercise on executive function and prefrontal cortex activity in healthy older adults. Pidnarulex Geriatr Gerontol Int 2022; 22 227-232.

These findings shed new light on the clinical effectiveness of acute moderate-intensity aerobic exercise on executive function and prefrontal cortex activity in healthy older adults. Geriatr Gerontol Int 2022; 22 227-232.Advanced electrocatalysts for complete oxidation of ethylene glycol (EG) in direct EG fuel cells are strongly desired owing to the higher energy efficiency. Herein, Pd-PdSe heterostructural nanosheets (Pd-PdSe HNSs) have been successfully fabricated via a one-step approach. These Pd-PdSe HNSs feature unique electronic and geometrical structures, in which unconventional p-d hybridization interactions and tensile strain effect co-exist. Compared with commercial Pd/C and Pd NSs catalysts, Pd-PdSe HNSs display 5.5 (6.6) and 2.5 (2.6) fold enhancement of specific (mass) activity for the EG oxidation reaction (EGOR). Especially, the optimum C1 pathway selectivity of Pd-PdSe HNSs reaches 44.3 %, illustrating the superior C-C bond cleavage ability. Electrochemical in situ FTIR spectroscopy and theoretical calculations demonstrate that the extraordinary p-d hybridization interaction and tensile strain effect could effectively reduce the activation energy of C-C bond breaking and accelerate CO* oxidation, boosting the complete oxidation of EG and improving the catalytic performance.