Dalgaardarnold0005

Finally, the amount of lifetime running exposure did not affect ankle kinetics during walking in middle-aged runners.PURPOSE To assess the effects of periodized versus nonperiodized dry-land strength training (DLST) on indices of swimming performance in well-trained adolescent swimmers. METHODS Sixteen athletes (10 boys and 6 girls; age 14.9 [1.1] y) performed similar endurance training for 16 weeks (29.1 [7.5] km·wk-1). During weeks 1 to 7, all athletes additionally performed 2 or 3 times weekly whole-body DLST (3 × 6-10 repetitions at 75-85% 1-repetition maximum [1RM]). Thereafter, the DLST frequency was maintained, but athletes were stratified into periodized (experimental, n = 9) and nonperiodized (control, n = 7) DLST groups. The experimental group performed maximal (3 × 3-4 repetitions at 85-90% 1RM) and explosive DLST (throws and unloaded jumps), while in the control group, DLST was maintained. RESULTS Swimming time at 4 mmol·L-1 of blood lactate improved after 7 weeks in both the experimental (+2.6% [1.8%], P = .033) and the control groups (+3.2% [2.4%], P = .081) and plateaued thereafter. Ten-meter start improved in both the experimental (-3.6% [2.5%], P = .039) and the control groups (-5.1% [2.2%], P = .054) throughout the entire intervention. Both groups improved in maximal weight lifted in half-squat (experimental, +19.6% [14.9%], P = .021; control, +25.7% [18.4%], P = .054) and bench press (experimental, +14.1% [4.8%], P = .018; control, +19.3% [11.1%], P = .051). Countermovement-jump height increased only in the experimental group throughout the intervention (+19.4% [7.0%], P = .024). The associations for the pooled changes in half-squat performance and 4 mmol·L-1 of blood lactate were statistically significant (r = .560, P = .024). CONCLUSIONS The findings do not support the superior effects of DLST periodization in adolescent swimmers. However, the association between improvements in lower-body strength and swimming performance still indicates the importance of muscle strength in this age group.Despite the prevalence of turning maneuvers in everyday life, relatively little research has been conducted on joint angle kinematic coordination during whole-body rotations around a vertical axis. Ballet pirouettes provide an opportunity to study dynamically balanced, whole-body rotations on a single support and the potential to scale results to smaller angular displacements executed by general populations. The purpose of this study was to determine the supporting limb's ankle, knee, hip, and pelvis-trunk joint angle excursions and kinematic coordination strategies utilized during the pirouette's turn phase. Advanced dancers (n = 6) performed pirouettes while whole-body 3-dimensional kinematics were recorded. Group mean ankle ab/adduction excursion was significantly greater than all other excursions (P less then .05). Principal components analysis was applied to joint angle time-series data (4 joints × 3 degrees of freedom = 12 variables). The first 4 principal components explained 92% (2%) of variance, confirming redundancy in joint angle data. Evolution of the data along the first principal component in successful pirouettes oscillated at the pirouette's rotational frequency. Principal component eigenvector coefficients provided evidence of ankle-hip coordination, although specific coordination patterns varied between individuals and across trials. These results indicate that successful pirouettes are executed with continuous, oscillatory joint angle coordination patterns.In this study, the network pharmacology analysis method was used to explore the bioactive components and targets of Xianlinggubao (XLGB) and further elucidate its potential biological mechanisms of action in the treatment of osteoporosis (OP). The bioactive compounds and predictive targets of XLGB were collected from the traditional Chinese medicine systems pharmacology databases and analysis platform(TCMSP), the Encyclopeida of traditional Chinese medicine (ETCM), traditional Chinese medicine Databse@Taiwan, ChEMBL, STITCH, and SymMap database. The targets corresponding to OP were obtained by using Online Mendelian Inheritance in Man® (OMIM), GeneCards, the National Center for Biotechnology Information-Gene database. The XLGB-OP targets were obtained by intersecting with the targets of XLGB and OP. Protien-Protien interaciton (PPI) network was constructed using STRING online database and analyzed using Cytoscape 3.7.0 software to screen out hub genes. Gene ontology (GO) and KEGG enrichment analysis of the target in the PPI network was conducted using the ClusterProfiler package in R with adjusted p-value less then 0.05. A total of 65 XLGB bioactive compounds were screened corresponding to 776 XLGB targets and 2556 OP targets. The GO analysis and KEGG enrichment analyses suggested XLGB played a therapeutic roles in OP treatment via the interleukin-17 signaling pathway, hypoxia-inducible factor-1 signaling pathway, insulin resistance, Th-17 signaling pathway, etc. Five hub genes (AKT1, MAPK1, MAPK8, TP53, and STAT3) were screened using the degree algorithm, and molecular docking stimulation results showed that most bioactive compounds of XLGB had strong binding efficiency with hub genes. Navitoclax Overall, this study laid the foundation for further in vivo and in vitro experimental research and expanded the clinical applications of XLGB. BACKGROUND A growing body of literature has suggested that effective emotion regulation is influenced by cognitive function. Maintenance and manipulation of internal representations occur in working memory (WM), and impairments of WM have been reported in patients with bipolar disorder. METHODS We examined the manipulation ability of internal representations in WM using mental rotation (MR) tasks, and compared the task performances of euthymic bipolar I disorder patients to those of schizophrenia patients and healthy controls. In this study, 20 euthymic bipolar I disorder patients, 20 schizophrenia patients, and 38 healthy controls were recruited. People and letter MR tasks were employed to evaluate the ability of WM manipulation. RESULTS Compared to healthy controls, euthymic bipolar I disorder patients showed substantially higher error rates of people MR task and slower responses in both people and letter MR tasks. Schizophrenia patients showed no difference in error rate and response time in MR tasks compared to healthy controls; however, they showed significantly slower responses in people MR task compared to controls.