Currinshoemaker3104

Our results showed the overexpression of YAP1 and Survivin as well as a decreased activity of large tumor suppressor 1 (LATS1) in high-grade glioblastoma versus anaplastic astrocytoma and low-grade glioma. Furthermore, we also demonstrated that miR-221 and miR-10b are specifically involved in Hippo signaling via LATS1 regulation and that their knockdown significantly decreased glioma cell proliferation. This preliminary data confirmed the crucial role of the Hippo pathway in cancer and suggested that miR-221 and miR-10b could be potential therapeutic targets for glioma treatment.A series of actinia-shaped lignin-based adsorbents (LNAEs) featuring lignin(LN) as the core and grafted poly(acrylic acid) (PAA) as the tentacle were designed and fabricated. LNAEs were applied to remove ofloxacin and ciprofloxacin from water, and their maximum adsorption capacities were 0.835 and 0.965 mmol/g at pH 6.0, respectively. However, their adsorption capacities were up to about 20 % and 31 % reductions in the present of NaCl and humic acid, respectively. Electrostatic attraction (EA) and hydrogen bonding (HB), including ordinary HB and negative charged auxiliary HB, were mainly involved in adsorption. Diphenyleneiodonium Experimental and calculation results indicated HB contributes more than EA. The effects of two structural factors of LNAEs, namely, PAA branched-chain length(L) and distribution density(D), on the adsorption performance associated with HB and EA, were quantitatively discussed using a binary nonlinear model based on phenomenological theory. The fitting results were completely consistent with the experimental findings. D was more efficient than L in promoting HB and EA in adsorption due to the cooperative effects of adjacent branched-chains and enhanced activity of terminal groups. This study provides a better understanding of the structure-activity relationship of surface grafting-modified adsorbents and fundamental guidance for the exploitation and design of novel and efficient adsorbents.Sintering dust is considered as a hazardous waste material owing to its high heavy metal content. In this study, a new technology for the treatment of sintering dust via chlorination roasting was developed. The chlorination behavior of Pb at high temperatures was studied. The volatilization behavior of Pb and Cl was found using different analytical techniques, such as scanning electron microscopy and energy dispersive X-ray spectrometry, X-ray diffraction, X-ray photoelectron spectroscopy, X-ray fluorescence, and atomic absorption spectroscopy. In addition, the thermodynamics and kinetics of the chlorination mechanism of Pb at high temperatures were studied. Thermodynamic analysis results showed that quartz and the chlorinating agent played key roles in the process of chlorination. Compared with KCl and NaCl, CaCl2 showed superiority in the chlorination. The phase transformation of sintering dust at different temperatures was analyzed. The volatilization rates of Pb and Cl reached 98.69 % and 84.55 %, respectively. The study of kinetics showed that the volatilization of PbCl2 was controlled by diffusion, and the apparent activation energy is 7.97 kJ/mol. Finally, chlorination roasting residue can be recycled for iron and steel metallurgy.To better deal with the radioactive iodine generated during the development of nuclear energy, B2O3, Bi2O3, ZnO, and SiO2 were used to sinter borosilicate glass for the immobilization of iodine. The effect of B2O3 on glass formation was discussed by changing the molar ratio of B2O3 in the matrix. When B2O3 content is 50 mol% and sintering temperature is 600 ℃, the amorphous degree of quaternary glass is the highest. The sintered body with the highest degree of amorphous was selected to study radioactive iodine. Then, the effects of different iodine loading concentrations for sintering borosilicate glass in terms of microstructure and phase change were discussed. With the increase in iodine content on silica-gel, the degree of amorphous of the specimens presented a decreasing trend, and there are obvious SiO2 peaks. When the content was 20 wt.%-30 wt.%, a large number of new phases were generated. When the iodine content is 20 wt.%, in addition to the enrichment of Si and O elements, the elemental distribution for B, Bi, Zn, I, and Ag was even. TEM results also showed that there was a crystalline phase in the sinter.CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal tissues to limit excessive immune response. However, tumors take advantage of the CD73-mediated adenosinergic mechanism to protect them from immune attack. In particular, inducible expression of CD73 along with other adenosinergic molecules on both cancer cells and host cells sustains immunosuppressive tumor microenvironment by affecting multiple aspects of the immune response. Owing to its multifaceted capacity to tumor promotion as an emerging immune checkpoint, CD73 is an ideal therapeutic target for cancer treatment especially in combination with conventional therapy and/or other immune checkpoint inhibitors. In this review, we will discuss the roles of CD73 on tumor and immune cells and will highlight the therapeutic value of CD73 for combination therapy.

Recently SARS-CoV-2 has spread worldwide causing a pandemic. Little is known about disease severity in immunocompromised hosts and people receiving disease modifying therapies (DMTs). In the last decades DMTs have been widely employed, and ocrelizumab represents one of the newest therapies for the relapsing remitting and progressive forms of multiple sclerosis (MS).

to describe SARS-CoV-2 related pneumonia in two MS patients under ocrelizumab treatment.

Case series.

Patients showed a mild clinical course of SARS-CoV-2 related pneumonia without complications or sequelae.

Ocrelizumab treatment is not necessarily associated to increased severity in MS patients with SARS-CoV-2 infection.

Ocrelizumab treatment is not necessarily associated to increased severity in MS patients with SARS-CoV-2 infection.

People with Intellectual Disability (ID) and epilepsy are more likely to experience psychiatric conditions, challenging behaviour (CB), treatment resistance and adverse effects of anti-seizure medications (ASM) than those without. This population receives care from various professionals, depending on local care pathways. This study evaluates the training status, confidence, reported assessment and management practices of different professional groups involved in caring for people with ID, epilepsy and CB.

A cross sectional survey using a questionnaire developed by expert consensus which measured self-reported training status, confidence, and approaches to assessment and management of CB in people with ID and epilepsy was distributed to practitioners involved in epilepsy and/or ID.

Of the 83 respondents, the majority had either a psychiatry/ID (n = 39), or Neurology/epileptology background (n = 31). link2 Psychiatry/ID and Neurology/epileptology had similar confidence in assessing CB in ID-epilepsy cases, but management. As such, training opportunities in ID should be offered to neurology professionals, and vice versa. Based on the findings, a best practice checklist is presented, which aims to provide clinicians with a structured framework to consider causal explanations for CB in this population.Open-faced charcoal canisters have been used for radon measurements for over 40 years. This method is sensitive to temperature, changing radon concentrations, humidity and other parameters, but a comprehensive study dealing with the influence quantities and measurement uncertainty was not available in literature. In this paper, all the identified influence quantities are discussed in detail, uncertainty budget is developed, good practice and bad practice examples are introduced and new recommendations are proposed to optimize the method and reduce uncertainty.In Argentina, a multi-institutional project has been established to assess the feasibility of applying BNCT ex-situ to the treatment of patients with multiple metastases in both lungs. Within this context, this work aims at applying the neutron autoradiography technique to study boron microdistribution in the lung. A comprehensive analysis of the different aspects for the generation of autoradiographic images of both normal and metastatic BDIX rat lungs was achieved. Histology, boron uniformity, optimal tissue thickness and water content in tissue were explored for the two types of samples. A qualitative and a quantitative analysis were performed. No heterogeneities in uptake were observed in normal lung. Conversely, samples with metastasis showed preferential boron uptake in the tumour areas with respect to surrounding tissue. Surrounding tissue would present a slightly higher uptake of boron than the normal lung. Quantitative results of boron concentration values and ratios determined by neutron autoradiography were obtained. In order to contribute to BNCT dosimetry, further analysis increasing the number of samples is warranted.Activity concentrations of tea samples were determined using high resolution gamma spectrometry.The values ranged from (421.00 ± 17.00) to (732.00 ± 30.00) Bq.kg -1 for K-40 and from (3.00 ± 0.80) to (27.00 ± 3.00) Bq.kg-1 for Ra-228. The values for Ra-226 were below 27.00 Bq.kg-1. The committed effective dose was estimated at 4.74-78.89 μSv.y-1 for adults and 13.55-445.84 μSv.y-1 for children. The cancer risk was higher for females. However, results showed that the tea consumption do not represent a radiological health risk to the population.Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with a human breast cancer cell line and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.The aim of this study is to determine the release of TiO2 from six sport garments into the wash water after 1, 2 and 10 washes. link3 For such, Total Reflection X-ray Fluorescence (TXRF) spectrometry was employed for the study of the wash water and Scanning Electron Microscopy - Energy Dispersive Spectrometry (SEM-EDS) was used for the analysis of the textiles. Results showed that the six sport garments released between 0.106 mg/L and 0.352 mg/L after the first two washes and between 0.028 mg/L and 0.337 mg/L of Ti after ten washes. The values found for the Ti amount released in wash water, and consequently into the environment, is much less than other common sources. These results showed the potential of TXRF spectrometry in quantifying Ti in wash water, which is a hard task even for well-established methods. SEM images show that all six samples were weft knitted fabrics, with yarns of approximately 250 μm of width and fibers' width between 9 and 13 μm.