Currinsheehan2834

These data highlight the importance of considering both frailty and age when seeking to identify at-risk patients who might benefit from closer follow-up after discharge.

Patients with pre-existing frailty who develop critical illness have higher rates of hospital readmission and death than patients without frailty, and age modifies these associations. These data highlight the importance of considering both frailty and age when seeking to identify at-risk patients who might benefit from closer follow-up after discharge.

To provide a comprehensive review of studies that have investigated fatigue in intensive care unit (ICU) survivors and questions the potential link between intensive care unit-acquired weakness (ICUAW), fatigability and fatigue. We also question whether the central nervous system (CNS) may be the link between these entities.

A narrative review of the literature that investigated fatigue in ICU survivors and review of clinical trials enabling understanding of CNS alterations in response to ICU stays.

Fatigue is a pervasive and debilitating symptom in ICU survivors that can interfere with rehabilitation. this website Due to the complex pathophysiology of fatigue, more work is required to understand the roles of ICUAW and/or fatigability in fatigue to provide a more holistic understanding of this symptom. While muscle alterations have been well documented in ICU survivors, we believe that CNS alterations developing early during the ICU stay may play a role in fatigue.

Fatigue should be considered and treated in ICU survivors. The causes of fatigue are likely to be specific to the individual. Understanding the role that ICUAW and fatigability may have in fatigue would allow to tailor individual treatment to prevent this persistent symptom and improve quality of life.

Fatigue should be considered and treated in ICU survivors. The causes of fatigue are likely to be specific to the individual. Understanding the role that ICUAW and fatigability may have in fatigue would allow to tailor individual treatment to prevent this persistent symptom and improve quality of life.

The purpose of this study was to investigate the relationship between depressive symptoms and suicidal ideation and living with stuttering while accounting for time, sex, and health-related confounders.

The data for this study come from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative survey study that has followed 13,564 respondents over the course of 14 years. Responses to the question "Do you have a problem with stuttering or stammering?" at two time points were used to establish stuttering and non-stuttering groups. Regression analysis, propensity score matching, and structural equation modeling were used.

Compared to their fluent counterparts, males and females reported significantly elevated symptoms of depression. Although symptoms of depression among males who stutter were stable over time, depressive symptoms among females who stutter increased with age. Compared to males who do not stutter, males who stutter were significantly more likely to report feelings of suicidal ideation. There were no differences in suicidal ideation between females who do and do not stutter.

Speech-language pathologists should be aware of the associations between stuttering and depressive symptoms, as well as the increased risk for suicidal ideation among males who stutter. Clinicians should be knowledgeable about symptoms of depression and suicidal ideation and be familiar with processes to refer as needed.

Speech-language pathologists should be aware of the associations between stuttering and depressive symptoms, as well as the increased risk for suicidal ideation among males who stutter. Clinicians should be knowledgeable about symptoms of depression and suicidal ideation and be familiar with processes to refer as needed.

We examined the quality and readability of English-language Internet information about stuttering and evaluated the results considering recommendations by experts in health literacy.

A search of Internet websites containing information about stuttering was conducted. Three key words (i.e., stuttering, stammering, speech disfluency) were entered into five country-specific versions of the most commonly used Internet search engine. A total of 79 websites were assessed. Their origin (commercial, non-profit, government, personal or university), quality [Health On the Net (HON) certification and DISCERN scores], and readability [Flesch Reading Ease (FRE) score, Flesch-Kincaid Grade Level Formula (F-KGL), and Simple Measure of Gobbledygook (SMOG)] were assessed.

Of the 79 websites, 38 % were of commercial, 42 % were of nonprofit organization, 15 % were of government and 5% were of university origins, respectively. Only 13 % had obtained HON certification and the mean DISCERN scores was 3.10 in a 5-point scale.information resource, speech-language pathologists and other healthcare professionals have an opportunity to direct consumers to websites that provide readable information of good quality.Triple-negative breast cancer (TNBC) heterogeneity represents one of the main obstacles to precision medicine for this disease. Recent concordant transcriptomics studies have shown that TNBC could be divided into at least three subtypes with potential therapeutic implications. Although a few studies have been conducted to predict TNBC subtype using transcriptomics data, the subtyping was partially sensitive and limited by batch effect and dependence on a given dataset, which may penalize the switch to routine diagnostic testing. Therefore, we sought to build an absolute predictor (i.e., intra-patient diagnosis) based on machine learning algorithms with a limited number of probes. To that end, we started by introducing probe binary comparison for each patient (indicators). We based the predictive analysis on this transformed data. Probe selection was first involved combining both filter and wrapper methods for variable selection using cross-validation. We tested three prediction models (random forest, gradient boosting [GB], and extreme gradient boosting) using this optimal subset of indicators as inputs. Nested cross-validation consistently allowed us to choose the best model. The results showed that the fifty selected indicators highlighted the biological characteristics associated with each TNBC subtype. The GB based on this subset of indicators performs better than other models.

The electrocardiogram (ECG) is a valuable diagnostic tool for the diagnosis of myocardial ischemia during acute coronary syndrome. Aside from the commonly used ST-segment shift indicative of ischemia, several other ECG parameters are pathophysiologically reasonable. Thus, the goal of this study was to assess the accuracy of different ischemia parameters as obtained by the highly susceptible intracoronary ECG (icECG).

This was a retrospective observational study in 100 patients with chronic coronary syndrome. From each patient, a non-ischemic as well as ischemic icECG at the end of a one-minute proximal coronary balloon occlusion was available, and analysed twice by three different physicians, as well as once together for consensual results. The evaluated parameters were icECG ST-segment shift (mV), ST-integral (mV*sec), T-wave-integral (mV*sec), T-peak (mV), T-peak-to-end time (TPE; msec) and QTc-time (msec).

All six icECG parameters showed significant differences between the non-ischemic and the ischemic recording. Using the icECG recording during coronary patency or occlusion as criterion for absent or present myocardial ischemia, ROC-analysis of icECG ST-segment shift showed an area under the curve (AUC) of 0.963±0.029 (p<0.0001). AUC for ST-integral was 0.899±0.044 (p<0.0001), for T-wave integral 0.791±0.059 (p<0.0001), for T-peak 0.811±0.057 (p<0.0001), for TPE 0.667±0.068 (p<0.0001), and for QTc-time 0.770±0.061 (p<0.0001). The best cut-off point for the detection of ischemia by icECG ST-segment shift was 0.365mV (sensitivity 90%, specificity 95%).

When tested in a setting with artificially induced absolute myocardial ischemia, icECG ST-segment shift at a threshold of 0.365mV most accurately distinguishes between absent and present ischemia.

When tested in a setting with artificially induced absolute myocardial ischemia, icECG ST-segment shift at a threshold of 0.365 mV most accurately distinguishes between absent and present ischemia.

It has been reported in the literature that the increase in body temperature shortens QT interval on electrocardiogram through heart rate modulation. However, the effects of fever on ventricular repolarization are not clearly known. This study elaborates on QT interval of isolated fever, corrected QT (cQT), Tp-e interval, the ratio of corrected Tp-e (cTp-e) and Tp-e/QT, and their impacts on arrhythmia potential.

This prospective study was performed on 74 patients without any active and chronic diseases other than fever and upper respiratory tract infection. The study included patients at the age of 18-50years suffering from fever above 38.2°C. QT and Tp-e intervals of the patients were measured from their ECGs taken in febrile and afebrile periods. cQT and cTp-e values were calculated according to Bazett, Fridericia, and Framingham formulations.

QT and Tp-e intervals were observed to be shorter in the febrile period (p<0.001 and p=0.006 respectively). cTp-e was found to be longer in the febrile period according to Bazett, Fridericia, and Framingham formulations (p<0.001, p=0.002, p<0.001, respectively). Tp-e/QT ratio was found to be higher in the febrile period than in the afebrile period (p<0.001).

Although QT, cQT, and Tpe intervals were shorter, cTpe interval and Tpe/QT ratio were longer and higher in the febrile period, respectively. These findings may indicate that fever may create a proarrhythmic effect by causing variability in the transmural distribution of myocardial repolarization.

Although QT, cQT, and Tpe intervals were shorter, cTpe interval and Tpe/QT ratio were longer and higher in the febrile period, respectively. These findings may indicate that fever may create a proarrhythmic effect by causing variability in the transmural distribution of myocardial repolarization.Following the mysterious health attacks on U.S. diplomats in Cuba in 2016, the cause of concussion-like symptoms concurrent with strange noises heard by the diplomats remains undetermined. A wide range of possible causes of the sensations have been proposed pulsed microwave exposure, infrasound acoustic devices, pesticides/neurotoxins, and even mass hysteria (psychogenic illness). Here, we numerically examine the pulsed microwave exposure hypothesis and the simulated mechanical response of brain tissue. A computational model is used to examine the influence of various spatially varying temperature gradients and pulse durations on the mechanical response of brain tissue. We show that a stress-focusing effect due to a rapid temperature increase may result in brain tissue strains larger than the initially applied thermal strains.The electrochemical energy storage performance of activated carbons (ACs) obtained from coffee-derived biowastes was assessed. ACs were obtained from spent coffee ground second waste, after polyphenol extraction, by means of a hydrothermal process followed by physical or chemical activation. The resulting materials exhibited microporous structures with a total specific area between 585 and 2330 m2·g-1. Scanning electron microscopy (SEM) revealed a highly porous microstructure in the case of the chemically activated carbons, while physical activation led to a cracked micro-sized morphology. The electrochemical properties of the materials for supercapacitor applications were investigated in 1 M Na2SO4. After chemical activation, the coffee-derived material displayed a capacitance of 84 F·g-1 at 1 A·g-1 in a 1.9 V voltage window, with 70% capacitance retention at 10 A·g-1 and 85% retention after 5000 cycles of continuous charge-discharge. This work demonstrates how coffee secondary biowaste can be conveniently activated to perform as electrochemical energy storage material, contributing to its revalorization and reinsertion in a circular economy.