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function; in addition the dichotomous variables of age over 75 years and ACCI more than 7 were significant predictors of hospital stay. No outcomes were significantly associated with Clavien-Dindo grading. Sub-group analysis demonstrated that patients aged over 75 years had a longer LOS (median 6 -IQR 5-8-
7 -IQR 6-12- d,
= 0.013) and later TFF (median 2 -IQR 1-3-
3 -IQR 2-4- d,
= 0.008), while patients with ACCI more than 7 were only associated with a prolonged hospital stay (median 7 -IQR 5-8-
7 -IQR 6-14.5- d,
= 0.036).
RRH is related to shorter LOS when compared with the laparoscopic approach, but older age and several comorbidities tend to reduce its benefits.
RRH is related to shorter LOS when compared with the laparoscopic approach, but older age and several comorbidities tend to reduce its benefits.
There is an increased need for accurate staging for gastric cancer treatment. Consequently, it is necessary to carefully examine all dissected lymph nodes for precise staging. learn more Recently, the fat-dissociation method has been developed as a quick and accurate method for harvesting dissected lymph nodes of colorectal cancer cases.
To investigate the usefulness of the fat-dissociation method for harvesting dissected lymph nodes of gastric cancer cases.
Fifty-six resected specimens from gastric cancer patients who underwent standard curative gastrectomy and lymph node dissection at our hospital were used. Group 2 lymph nodes were separated from each specimen, and the remaining adipose tissue containing the group 1 lymph nodes was used. Some resected specimens were subjected to the fat-dissociation method. One vial of Imofully
was dissolved in 50 mL of saline and injected into the tissue. The tissue was incubated for 1 h and the dissolved fat was removed. Subsequently, the nodes were identified, picked up wiy.
Nonalcoholic fatty liver disease (NAFLD) presents high incidence throughout the world and has been progressively increasing in prevalence. This disease has a heterogeneous natural history, including simple steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. The factors that determine its evolution to more severe forms of the disease are still poorly understood, and micronutrients with antioxidant potential may be involved in the pathophysiology of the disease.
To evaluate the relationship between serum levels of micronutrients and the severity of NAFLD.
A retrospective, observational and cross-sectional study was conducted. This study included all patients undergoing bariatric surgery who experienced liver biopsy during the procedure, and had serum levels of micronutrients (vitamin D, vitamin B12, zinc, iron, and magnesium), which was assessed in a preoperative evaluation conducted at a reference center in southern Brazil.
A total of 614 patients were analyzed, of which 93% had steatosis, 70.7% had NASH, and 49.3% had some degree of fibrosis. Serum levels of vitamin D were negatively correlated with the severity of steatosis and NASH, and serum levels of vitamin B12 were positively correlated with the severity of steatosis and fibrosis. The other micronutrients showed no association with NAFLD staging.
Serum levels of vitamin D are inversely related to the severity of steatosis and NASH, and serum levels of vitamin B12 are higher in more advanced stages of simple steatosis and liver fibrosis. Serum levels of zinc, iron, and magnesium were not associated with NAFLD severity.
Serum levels of vitamin D are inversely related to the severity of steatosis and NASH, and serum levels of vitamin B12 are higher in more advanced stages of simple steatosis and liver fibrosis. Serum levels of zinc, iron, and magnesium were not associated with NAFLD severity.One-hundred years after the 1918-19 H1N1 flu pandemic and 10 years after the 2009 H1N1 flu pandemic, another respiratory virus has now inserted itself into the human population. Severe acute respiratory syndrome coronavirus has become a critical challenge to global health with immense economic and social disruption. In this article we review salient aspects of the coronavirus disease 2019 (COVID-19) outbreak that are relevant to surgical practice. The emphasis is on considerations during the pre-operative and post-operative periods as well as the utility and limitations of COVID-19 testing. The focus of the media during this pandemic is centered on predictive epidemiologic curves and models. While epidemiologists and infectious disease physicians are at the forefront in the fight against COVID-19, this pandemic is also a "stress test" to evaluate the capacity and resilience of our surgical community in dealing with the challenges imposed to our health system and society. As recently pointed out by Dr. Anthony Fauci, the virus decides the timelines in the models. However, the models can also change based on our decisions and behavior. It is our role as surgeons, to make every effort to bend the curves against the virus' will.Airway remodeling represents the healing and alteration in the airway that occur as a consequence of chronic inflammation. Extracellular matrix synthesis regulated by transforming growth factor (TGF-β1) and vascular remodeling regulated by epidermal growth factor (EGF) are important factors for the airway remodeling. This study aimed to probe the effect of catalpol, a major component of Radix Rehmanniae Preparata (Shudihuang), on airway remodeling and expression of TGF-β1 and EGF in asthmatic mice. A mice model of asthma was induced by ovalbumin (OVA) treatment. BALB/c mice were randomly divided into blank control group, asthma model group, dexamethasone (DEX) group (positive control), high, medium and low dose of catalpol intervention group. Changes in lung histology were observed using hematoxylin and eosin staining. The levels of TGF-β1 and EGF in mouse sera and bronchoalveolar lavage fluid (BALF) were examined by ELISA. The EGF mRNA and protein levels in mice tissues were determined. The results indicated that catalpol improved general conditions and reduced the damage of lung tissues in asthmatic mice. Moreover, results of ELISA revealed that catalpol significantly reduced the OVA-induced levels of TGF-β1 and EGF in sera and in bronchoalveolar lavage fluid (BALF). Additionally, results indicated that catalpol decreased the OVA-induced EGF mRNA and protein expression in lung tissues in asthmatic mice. Catalpol at a high dose was more efficient in decreasing the level of TGF-β1 in mice sera and BALF comparing the DEX group. Current study has demonstrated that catalpol might effectively prevent airway remodeling in asthma via inhibiting TGF-β1 and EGF.
