Cullenholcomb0235

Today, a new β-coronavirus called SARS-CoV-2 has emerged and it is causing a global pandemic. SD-208 molecular weight Inter-human transmission studies have indicated a significant role of aerosols in the transmission of many respiratory viruses. Hence, it is very important to decrease the spread of the virus through disinfectant agents. This review aimed to provide an overview related to possible alternative inhibitory molecules against this virus.

For this review the literature search was performed in the MEDLINE electronic database using the public access known as NCBI-PUBMED. Keywords 'coronavirus' and "SARS-CoV-2" and "COVID19" were used. No specific time range was used.

We provide a review related to structure, anti-coronavirus activity and molecular mechanism of natural substances and semisynthetic derivatives such as glycopeptides, lipopeptides, probiotics, surfactants, terpenes and resveratrol. We also include the latest in vitro experiments with anti-SARS-CoV-2 activity. We also provide the theoretical basis for discussing the prospects of such natural molecules as possible alternative anti-Coronavirus products, so as to develop a complete screening for future applications.

In summary, this review suggest to investigate deeper several molecules most of which belong to natural substances to fight COVID19 disease.

In summary, this review suggest to investigate deeper several molecules most of which belong to natural substances to fight COVID19 disease.Diabetes mellitus is a disease that presents great challenges for health systems worldwide, and the identification of alternative therapies for the treatment of this disease is of vital importance. Metallic nanoparticles (gold, silver, and selenium) and metallic oxide (ZnO) have been studied in different areas such as medicine, biotechnology, the environment, and the food industry with promising results. In medicine, current research has revealed these nanoparticles' antidiabetic properties thanks to the implementation of animal models. This review will address the existing antecedents and the effects of gold, silver, selenium, and zinc oxide nanoparticles in diabetes administered alone, functionalized with other molecules or combined with drugs that have shown promising therapeutic effects. The antidiabetic effects of these nanoparticles are related to the regulation of glucose, insulin, and lipid profiles. In addition, oxidative stress markers, liver and kidney markers, the reduction of inflammation, apoptosis of the pancreas, and the restoration of normal liver and kidney histology are also reported in the literature after using these nanoparticles. However, the therapeutic effects that these nanoparticles provide are limited due to the lack of specific protocols dictated by international organizations to evaluate the risks of using these nanoparticles.

Linum usitatissimum or flax has been broadly utilized in numerous milieus world-wide as a primeval medicinal plant because of its health benefits in diverse types of diseases.

The objective of this review is to assemble the latest information on the botanical description, distribution, conventional uses, and biochemical constituents, along with the pharmacological activities and toxicity of flax .

For this purpose, data on Linum was accumulated from scientific journals, books, and worldwide acknowledged scientific databases via a library and electronic search.

Phytochemical analysis showed that the major chemical constituents of L. usitatissimum are ω-3 fatty acid, phytoestrogenic lignans (secoisolariciresinol diglycoside-SDG), phenols, flavonoids, sterols, proteins, antioxidants as well as various soluble and insoluble fibres. Among them, secoisolariciresinol diglycosides (SDG) are the major bioactive compounds of L. usitatissimum with prospective pharmacological accomplishments. Pure compounds and crude extracts isolated from L. usitatissimum exhibited significant anti-cancer, antioxidant, anti-microbial, anti-inflammatory, anti-obesity, anti-diabetic, anti-diarrheal, anti-malarial, hepato-protective, reno-protective, immunosuppressive, antiarrhythmic, and cognitive effects. Studies indicated that the toxicological effect from the consumption of flaxseed is because of its cyanogenic glycosides, linatine, and cadmium, but the level doesn't seem to be adequately concentrated to contribute any physiological impact.

Further studies are expected to comprehend the detailed mode of action of its dynamic constituents as potent therapeutics and to completely reveal its preventive and healing potentials.

Further studies are expected to comprehend the detailed mode of action of its dynamic constituents as potent therapeutics and to completely reveal its preventive and healing potentials.

Amygdalin has anticancer benefits because of its active component, hydrocyanic acid. However, the underlying molecular mechanism is unclear.

This study aimed to investigate the molecular mechanism by which amygdalin exerts antiproliferative effects in the human Michigan Cancer Foundation-7 (MCF-7) breast cancer cell line.

MCF-7 cells were exposed to amygdalin at a particular IC50 value for 24 and 48 hours and compared to nontreated cells. An Affymetrix whole-transcript expression array was used to analyze the expression of 32 genes related to DNA replication.

Among the 32 genes, amygdalin downregulated the expression of 16 genes and 19 genes by >1.5-fold at 24 and 48 hours, respectively. At 24 hours, the downregulated genes from the DNA polymerase α-primase complex were POLA1, POLA2, PRIM1, and PRIM2; DNA polymerase δ complex POLD3; DNA polymerase complex POLE4, minichromosome maintenance protein (MCM) complex (helicase) MCM2, MCM3, MCM4, MCM6, and MCM7; clamp and clamp loader PCNA; nuclease FEN1; and DNA ligase LIG1. At 48 hours, the downregulated genes from the DNA polymerase α-primase complex were POLA1, POLA2, and PRIM1; DNA polymerase δ complex POLD3; DNA polymerase complex POLE and POLE2; MCM complex (helicase) MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7; clamp and clamp loader PCNA, RFC2, and RFC3; RNase H RNASEH2A; nucleases DNA2 and FEN1; and DNA ligase LIG1.

Amygdalin treatment caused downregulation of several genes that play critical roles in DNA replication in the MCF-7 cell line. Thus, it might be useful as an anticancer agent.

Amygdalin treatment caused downregulation of several genes that play critical roles in DNA replication in the MCF-7 cell line. Thus, it might be useful as an anticancer agent.