Crowelltennant9126

Along with the reduction in semiconductor chip size and enhanced performance of electronic devices, high input/output density is a desired factor in the electronics industry. To satisfy the high input/output density, fan-out wafer-level packaging has attracted significant attention. While fan-out wafer-level packaging has several advantages, such as lower thickness and better thermal resistance, warpage is one of the major challenges of the fan-out wafer-level packaging process to be minimized. There have been many studies investigating the effects of material properties and package design on warpage using finite element analysis. Current warpage simulations using finite element analysis have been routinely conducted with deterministic input parameters, although the parameter values are uncertain from the manufacturing point of view. This assumption may lead to a gap between the simulation and the field results. This paper presents an uncertainty analysis of wafer warpage in fan-out wafer-level packaging by using finite element analysis. Coefficient of thermal expansion of silicon is considered as a parameter with uncertainty. The warpage and the von Mises stress are calculated and compared with and without uncertainty.We present a highly stretchable and compact bow-tie antenna which operates at 5 GHz for wearable applications. The dimensions of the bow-tie antenna were 7.9 mm×17.8 mm. The stretchable antenna was fabricated with a composite mixture of silver flake and polymer binder. The composite paste was printed on polyurethane and textile using the screen printing technique. The RF performances, stretchability, bendability, and durability of the antennas were evaluated, which are critical requirements in wearable electronics. The stretchable bow-tie antennas showed excellent RF performances and stretchability up to a stretching strain of 40%. The antennas could be bent up to a bending radius of 20 mm without degrading RF performance. The stretchable antennas also exhibited outstanding mechanical endurance after 10,000 cyclic stretching tests. The antennas were not affected by the presence of the body and showed very stable RF performances, exhibiting promising results for mobile and wearable applications.In stretchable strain sensors, highly elastic elastomers such as polydimethylsiloxane (PDMS), Ecoflex, and polyurethane are commonly used for binder materials of the nanocomposite and substrates. However, the viscoelastic nature of the elastomers and the interfacial action between nanofillers and binders influence the critical sensor performances, such as repeatability, response, and hysteresis behavior. In this study, we developed a stretchable nanocomposite strain sensor composed of multiwalled carbon nanotubes and a silicone elastomer binder. see more The effects of binder and substrate materials on the repeatability, response, hysteresis behavior, and long-term endurance of the strain sensors were systematically investigated using stretching, bending, and repeated cyclic bending tests. Three different binder and substrate materials including PDMS, Ecoflex, and a mixture of PDMS/Ecoflex were tested. The stretchable strain sensors showed an excellent linearity and stretchability of more than 130%. Therefore, the lonbehavior, and excellent capability in detecting finger and wrist bending.This study explored the feasibility of a fast and uniform large-scale laser sintering method for sintering stretchable electrodes. A homogenized rectangular infrared (IR) laser with a wavelength of 980 nm was used in the sintering process. A highly stretchable composite electrode was fabricated using silver (Ag) microparticles and Ag flakes as the fillers and polyester resin as the binder on the polyurethane substrate. This laser-sintering method showed a sintering time of 1 sec and a very uniform temperature across the surface, resulting in enhancing the conductivity and stretchability of the electrodes. The effects of the laser power on the electrical and electromechanical properties of the electrodes were investigated. Using stretching, bending, and twisting tests, the feasibility of the laser-sintered stretchable electrodes was comprehensively examined. The electrode that was sintered at a laser power of 50 W exhibited superior stretchability at a strain of 210%, high mechanical endurance of 1,000 repeated cycles, and excellent adhesion. The stretchable electrodes showed excellent bendability and twistability in which the electrodes can be bent up to 1 mm and twisted up to 90° without any damage; thus, they are highly applicable as stretchable electrodes for wearable electronics. Additionally, the Ag composites were explored for use in a radio-frequency (RF) stretchable antenna to confirm the application of the laser-sintering method for stretchable and wearable electronic devices. The stretchable dipole antenna showed an excellent radiation efficiency of 95% and a highly stable operation, even when stretched to 90% strain.Recently, fine pitch wafer level packaging (WLP) technologies have drawn a great attention in the semiconductor industries. WLP technology uses various interconnection structures including microbumps and through-silicon-vias (TSVs). To increase yield and reduce cost, there is an increasing demand for wafer level testing. link2 Contact behavior between probe and interconnection structure is a very important factor affecting the reliability and performance of wafer testing. In this study, with a MEMS vertical probe, we performed systematic numerical analysis of the deformation behavior of various interconnection structures, including solder bump, copper (Cu) pillar bump, solder capper Cu bump, and TSV. During probing, the solder ball showed the largest deformation. The Cu pillar bump also exhibited relatively large deformation. The Cu bump began to deform at OD of 10 μm. At OD of 20 μm, bump pillar was compressed, and the height of the bump decreased by 8.3%. The deformation behavior of the solder capped Cu bump was similar to that of the solder ball. At OD of 20 μm, the solder and Cu bumps were largely deformed, and the total height was reduced by 11%. The TSV structure showed the lowest deformation, but exerted the largest stress on the probe. In particular, copper protrusion at the outer edge of the via was observed, and very large shear stress was generated between the via and the silicon oxide layer. In summary, when probing various interconnection structures, the probe stress is less than that when using an aluminum pad. On the other hand, deformation of the structure is a critical issue. In order to minimize damage to the interconnection structure, smaller size probes or less overdrive should be used. This study will provide important guidelines for performing wafer-level testing and minimizing damage of probes and interconnection structures.Phytosterols are sterols naturally occurring in plant cells and well known for their cholesterollowering activity, as witnessed by the large number of food supplements based on these functional ingredients available on the market. However, the marked hydrophobic character of phytosterols makes their solubility in biological fluids extremely low, with disadvantageous consequences on the bioavailability and therapeutic efficacy. link3 In this work, we explore the effect of particle size reduction on the water solubility of stigmasterol, one of the most abundant phytosterols, through the formulation of nanocystals. A robust, top-down production process was employed to prepare stigmasterol nanocrystals, subsequently characterized by thermal and spectroscopic techniques. When formulated as nanocrystals, the solubility of stigmasterol in water and in simulated gastro-intestinal fluids was boosted compared to the raw material. The increased solubility of stigmasterol nanocrystals makes such formulation a promising candidate for the development of medicinal/nutraceutical products with enhanced bioavailability.Liposomes represent, among the nanocarriers, the most useful ones for dermatological use, and their composition, charge, size strongly influence their performance in topical drug delivery systems, with possible accumulation of the loaded drugs in the hair follicles. Recently, a saw palmetto carbon dioxide (CO₂) extract has been reported useful for the treatment of hair loss because of the inhibition of 5α-reductase enzyme, responsible of the conversion of testosterone to the most potent androgen, the 5α-dihydrotestosterone. In this work, the formation of nano-sized liposomes and the encapsulation efficiency of saw palmetto CO₂ extract were investigated by light scattering techniques, microscopy and HPLC. The vesicles were loaded with 0.1% w/v saw palmetto CO₂ extract and were small in size (mean size of 145±5 nm). In addition, they were homogeneously dispersed (polydispersity index ≤0.27) and negatively charged (mean value -36.2±3.1 mV). The developed nanoliposomes could represent suitable drug delivery systems to treat the hair loss.The research on new radiopharmaceuticals for therapy of cancer is evolving rapidly. Thanks to novel technologies and new selective and less toxic compounds, we move towards personalized molecular medicine. The neutron capture radiation therapy (NCT) can be potentially much safer and can offer a better spatial and temporal control than the radioisotope therapy. Still, there are not many options in NCT the 10B isotope has been almost exclusively used for decades, and only recently, 157Gd has attracted some interest. Here, we want to draw attention to a new nuclide, 7Be, recently suggested for the NCT, and discuss perspective of Be2+ confinement in aqueous solutions and targeted delivery to cancerous tissues.Enzyme-containing Coordination Polymers (CPs) were prepared by a one-pot sonochemical method, mixing Glucose Oxidase (GOx) enzyme, 4,4'-bipyridine as spacer ligand, and chloride zinc salt. The reaction took place in a very short time (a few minutes) with a minimum use of solvents compared to conventional methods. The obtained composite material, named GOx-[Zn(4,4'-bipy)Cl₂]∞, resulted from embedding the GOx molecules into uniformly sized [Zn(4,4'-bipy)Cl₂] nanocrystals. The structural and thermal characterization, confirmed that the adopted strategy allows the preparation of hybrid bio-nanomaterials in a very fast, facile and eco-friendly method, by simply synthesising the [Zn(4,4'-bipy)Cl₂] nanocrystals in the presence of the enzyme.In this study, we present the preparation of superparamagnetic ordered mesoporous silica (SOMS) for biomedical applications by the combination of high energy ball milling (HEBM) and the liquid crystal template method (LCT) to produce a material comprised of room temperature superparamagnetic Fe₃O₄ nanoparticles in a MCM-41 like mesostructured silica. In a typical synthesis, a mixture of Fe₂O₃ and silica was sealed in a stainless-steel vial with steel balls. Ball milling experiments were performed in a vibratory mill apparatus. The milling process produced nanocomposites with an average size ranging from ∼100-200 nm, where the Fe₃O₄ nanoparticles (4.8 nm size) are homogeneously dispersed into the amorphous SiO₂ matrix. The obtained nanocomposite has been used for the preparation of the SOMS through the LCT method. Structural, morphological and textural characterization were performed using X-ray powder diffraction, transmission electron microscopy and nitrogen sorption analysis. Field dependence of magnetization was investigated and showed superparamagnetic behaviour at 300 K with a value of saturation magnetization (Ms) that is of interest for biomedical applications.