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This finding correlates with the improvement of functional outcome of the patients.

This study aimed to explore nurses' experiences in delivering emergency trauma care during the COVID-19 pandemic at a level I trauma centre in Saudi Arabia.

A qualitative, descriptive phenomenological design was utilised, in which face-to-face, unstructured interviews were carried out with emergency and trauma nurses at a level I trauma centre in Saudi Arabia. The study included nine registered emergency and trauma nurses who were interviewed twice from February to April 2021. The collected data were analysed using Colaizzi's descriptive phenomenological method.

The analysis of the data revealed an overarching theme that was about the inevitable change on the ground due to the pandemic and two primary themes, each containing two subthemes 1 dealing with an interrupted path of care; 1.1 experiencing additional complexity; 1.2 encountering extra demands; 2 optimising the path of care; 2.1 modifying the steps; and 2.2 transforming the system.

The COVID-19 pandemic imposed change on how trauma patients would be handled and treated. Nurses took an active and critical role in creating another form of change, which helped optimise the path of trauma care and accommodate urgent treatment needs of the injured patients.

The COVID-19 pandemic imposed change on how trauma patients would be handled and treated. Nurses took an active and critical role in creating another form of change, which helped optimise the path of trauma care and accommodate urgent treatment needs of the injured patients.Polyol synthesis of silver nanocubes (Ag NCs) under dark conditions yielded nanoparticles with high uniformity and purity, as well as edge lengths of 42 nm with good stability and scattering cross-section. These nanoparticles were characterized by SEM, TEM, and Uv-vis spectroscopy. The presence of polyvinylpyrrolidone (PVP) as a capping agent on the surface of Ag NCs, as well as its satisfactory interaction level with Haloperidol (Hp) as an antipsychotic drug, has led to the use of these nanoparticles as Resonance RayleighScattering (RRS) probe to measure Hp. Indeed, Hp resulted in reducing the RRS signal of Ag NCs, and this change in RRS intensity was linear in the range of 10.0 to 800.0 µg L-1 of Hp. The limits of detection (LOD) and quantification (LOQ) were found to be 1.5 and 5.0 µg L-1, respectively. The influence of interfering species was studied, and it was found that the suggested method has good selectivity and can be used to monitor Hp in actual samples. As a result, this RRS probe operated well in determining Hp in pharmaceutical and human plasma samples with satisfactory recovery.Nanocatalytic amplification of carbon dots is a new way to improve sensitivity. The preparation of the high catalytic activity and stable iron/nitrogen-doped carbon dot (CDBFe) sol and its application in aptamer (Apt) assay have not been reported yet. In this paper, a simple hydrothermal procedure for the preparation of CDBFe derived from Fe2+-2,2'-bipyridine complex has been developed. It is found that CDBFe has a strong catalytic effect on the indicator reaction of glyoxal (C2H2O2) reduction of HAuCl4 to produce gold nanoparticle (AuNP) probe with strong surface enhanced Raman scattering (SERS) at 1617 cm-1, resonance Rayleigh scattering (RRS) effect at 370 nm and absorption (Abs) at 550 nm. A rapid and sensitive CDBFe catalytic amplification Apt method for SERS/RRS/Abs trimode detecting ultratrace lead ions was established, based on the Apt reaction mediated the nanocatalytic indicator reaction. The results show that the SERS intensity and Pb(II) concentration have a good linear relationship in the range of 1.3-16 pM, and the detection limit is the lowest. In addition, Hg(II) and As(III) can also be measured by this naocatalytic amplification- Apt assay platform.There is both public and scholarly concern that (passive) social media use decreases well-being by providing a fertile ground for harmful (upward) social comparison and envy. The present review critically summarizes evidence on this assumption. We first comprehensively synthesize existing evidence, including both prior reviews and the most recent publications (2019-2021). Results show that earlier research finds social comparison and envy to be common on social media and linked to lower well-being. Yet, increasingly, newer studies contradict this conclusion, finding positive links to well-being as well as heterogeneous, person-specific, conditional, and reverse or reciprocal effects. The review identifies four critical conceptual and methodological limitations of existing evidence, which offer new impulses for future research.In this review, we systematize work on the relationship between social media use and stress by providing a functional perspective that distinguishes between three functions that social media can have in the stages of the stress-coping process as stressors, as resources, and as coping tools. Current research provides evidence that social media can cause stress, serve as resources, and can be used as a tool for various coping strategies, but it remains unclear when social media can successfully mitigate stress. Future research should use more fine-grained research designs that consider the timing of social media use, the situational context, and the encountered content to determine when social media serves which function and when social media reduces or increases stress.Fetal, infant, and toddler neuroimaging is commonly thought of as a development of modern times (last two decades). Yet, this field mobilized shortly after the discovery and implementation of MRI technology. Here, we provide a review of the parallel advancements in the fields of fetal, infant, and toddler neuroimaging, noting the shifts from clinical to research use, and the ongoing challenges in this fast-growing field. We chronicle the pioneering science of fetal, infant, and toddler neuroimaging, highlighting the early studies that set the stage for modern advances in imaging during this developmental period, and the large-scale multi-site efforts which ultimately led to the explosion of interest in the field today. Lastly, we consider the growing pains of the community and the need for an academic society that bridges expertise in developmental neuroscience, clinical science, as well as computational and biomedical engineering, to ensure special consideration of the vulnerable mother-offspring dyad (especially during pregnancy), data quality, and image processing tools that are created, rather than adapted, for the young brain.Steady-state visual evoked potential (ssVEP) frequency tagging is an increasingly used method in electrophysiological studies of visual attention and perception. Frequency tagging is suitable for studies examining a wide range of populations, including infants and children. Frequency tagging involves the presentation of different elements of a visual array at different temporal rates, thus using stimulus timing to "tag" the brain response to a given element by means of a unique time signature. Leveraging the strength of the ssVEP frequency tagging method to isolate brain responses to concurrently presented and spatially overlapping visual objects requires specific signal processing methods. click here Here, we introduce the FreqTag suite of functions, an open source MATLAB toolbox. The purpose of the FreqTag toolbox is three-fold. First, it will equip users with a set of transparent and reproducible analytical tools for the analysis of ssVEP data. Second, the toolbox is designed to illustrate fundamental features of frequency domain and time-frequency domain approaches. Finally, decision criteria for the application of different functions and analyses are described. To promote reproducibility, raw algorithms are provided in a modular fashion, without additional hidden functions or transformations. This approach is intended to facilitate a fundamental understanding of the transformations and algorithmic steps in FreqTag, and to allow users to visualize and test each step in the toolbox.

The Family Aggression Screening Tool (FAST) is an instrument to screen for experiences of maltreatment using primarily pictorial representations, including direct victimisation and exposure to intimate partner violence. The initial psychometric properties of the FAST were reported in the original research in the United Kingdom.

This research aimed to replicate and to extend the evaluation of the psychometric properties of FAST in Brazil.

Data consisted of 648 youth aged 11 to 17 years from public schools in Brazil.

We employed confirmatory factor analysis (CFA), exploratory factor analysis (EFA) and exploratory graphical analysis (EGA). Concurrent validity was supported by strong correlations between the FAST's emotional and physical victimisation subscales and Childhood Trauma Questionnaire (CTQ) emotional and physical abuse subscales.

CFA resulted in a solution including second and first order factors, resembling the original structure. FAST's reliability was assessed both through internal consistency and test-retest, showing favorable coefficients.

Our results suggest that FAST has good psychometric properties for the Brazilian population with respect to both its validity and reliability.

Our results suggest that FAST has good psychometric properties for the Brazilian population with respect to both its validity and reliability.The aim of this study was to establish an alginate encapsulation procedure for stallion sperm, and investigate if sperm encapsulation enhances longevity during cold storage and survival after cryopreservation. First, biocompatibility of the compounds needed for encapsulation was tested and factors determining capsule structure were identified. Sperm encapsulation was realized either by depositing droplets (20 µL) of sperm solution supplemented with barium or calcium chloride (10 mM) in alginate solution (0.25%, w/v), or by adding sperm-alginate droplets in solution containing barium or calcium chloride, and hardening (10 min). The first procedure resulted in structures with sperm residing in a liquid core surrounded by a spherical alginate shell, whereas the second procedure resulted in sperm embedded in solid beads of alginate matrix. It was found that use of calcium for alginate gelation resulted in decreased sperm motility as compared to using barium, and that encapsulation in solid beads had a negative impact on sperm plasma membrane intactness. Percentages of membrane intact sperm in barium-alginate core-shell structures were similar as found for ordinary diluted sperm, and did not change during 4 d storage at 5 °C. Sperm motility was reduced after direct recovery from core-shell structures, however, remained stable during 4 d storage leading to similar values as found for un-encapsulated sperm at this time point. Cryosurvival of sperm encapsulated in solid beads or core-shell structures was found to be lower compared to that of ordinary diluted sperm.Dendritic cells (DCs) have the unique capacity to link innate to adaptive immunity. While most cells that express major histocompatibility (MHC) molecules are able to present antigens to activated T cells, DCs possess the means for presenting antigens to naïve T cells, and, as such, are able to instruct T cells to initiate immune response. There are two cascades of events necessary for DCs to start their instructive function. First, DCs enzymatically process proteins to make T cells recognize an antigen as unique peptide-MHC complexes. Second, DCs provide secretory cytokines and co-stimulatory functions for T cells to respond to this antigen. Thus, the compartments for protein degradation and for protein synthesis are central to DC function. The endoplasmic reticulum (ER), a vast network of membranes and vesicles, connects these compartments and helps modulate DC-specific performance, such as antigen capture and presentation. However, while the health of ER appears relevant for DC function, the intersection between ER stress and antigen presentation remains to be explored.