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Carbon nanomaterials have received increased attention in the last few years due to their potential applications in several areas. In medicine, for example, these nanomaterials could be used as contrast agents, drug transporters, and tissue regenerators or in gene therapy. This makes it necessary to know the behavior of carbon nanomaterials in biological media to assure good fluidity and the absence of deleterious effects on human health. In this work, the rheological characterization of different graphene nanomaterials in fetal bovine serum and other fluids, such as bovine serum albumin and water, is studied using rotational and microfluidic chip rheometry. Graphene oxide, graphene nanoplatelets, and expanded graphene oxide at concentrations between 1 and 3 mg/mL and temperatures in the 25-40 °C range were used. The suspensions were also characterized by transmission and scanning electron microscopy and atomic force microscopy, and the results show a high tendency to aggregation and reveals that there is a protein-nanomaterial interaction. Although rotational rheometry is customarily used, it cannot provide reliable measurements in low viscosity samples, showing an apparent shear thickening, whereas capillary viscometers need transparent samples; therefore, microfluidic technology appears to be a suitable method to measure low viscosity, non-transparent Newtonian fluids, as it is able to determine small variations in viscosity. No significant changes in viscosity are found within the solid concentration range studied but it decreases between 1.1 and 0.6 mPa·s when the temperature raises from 25 to 40 °C.Migraine is a neurological disorder characterized by severe headaches, visual aversions, auditory, and olfactory disorders, accompanied by nausea and vomiting. Zolmitriptan (ZMT®) is a potent 5HT1B/1D serotonin receptor agonist frequently used for the treatment of migraine. It has erratic absorption from the gastrointestinal tract (GIT), but its oral bioavailability is low (40-45%) due to the hepatic metabolism. This makes it an ideal candidate for oral fast dissolving formulations. Hence, the current study was undertaken to design and develop oral fast-dissolving films (OFDFs) containing ZMT for migraine treatment. The OFDFs were formulated by the solvent casting method (SCM) using Pullulan (PU) and maltodextrin (MDX) as film-forming agents and propylene glycol (PG) as a plasticizer. The strategy was designed using Box-Behnken experimental design considering the proportion of PUMDX and percentage of PG as independent variables. The effectiveness of the OFDF's was measured based on the following responses druh might endeavor ZMT-OFDFs as an auspicious alternative approach to improve patient compliance and shorten the onset time of ZMT in migraine treatment.Buton Rock Asphalt (BRA) refers to the natural rock asphalt natively produced on the Buton island of Indonesia. It is often used as a modifier to enhance the performance of asphaltpavement. However, the segregation of BRA in BRA-Modified Asphalt (BRA-MA) has restricted its application. This study aims to investigate how the particle size and content of BRA affect the physical properties and storage stability of BRA-MA. Penetration, softening point, viscosity, and viscosity-temperature susceptibility (VTS) were analyzed. The evaluation method of storage stability was discussed and determined. The segregation of BRA in BRA-MA of static storage and transportation process were simulated and tested. The results suggest that the softening point and viscosity were positively correlated to BRA content and inversely determined by particle size. Penetration, VTS, and ductility were reduced due to the decline in particle size and increment of BRA content. The index of segregation value based on viscosity difference showed better statistical and quantitative significances than the softening-point difference in evaluating the storage stability. The particle size and content of BRA are positively correlated to the segregation of BRA-MA. Both the storage temperature and time were positively correlated to the segregation of BRA-MA. We prove that the relationship between specific surface area and segregation are power functional. BRA-MA with BRA whose 50% particle sizes are lower than 13.6 μm showed low segregation in transportation.In this manuscript, a novel dual-step selective epitaxy growth (SEG) of Ge was proposed to significantly decrease the defect density and to create fully strained relaxed Ge on a Si substrate. With the single-step SEG of Ge, the threading defect density (TDD) was successfully decreased from 2.9 × 107 cm-2 in a globally grown Ge layer to 3.2 × 105 cm-2 for a single-step SEG and to 2.84 × 105 cm-2 for the dual-step SEG of the Ge layer. This means that by introducing a single SEG step, the defect density could be reduced by two orders of magnitude, but this reduction could be further decreased by only 11.3% by introducing the second SEG step. The final root mean square (RMS) of the surface roughness was 0.64 nm. The strain has also been modulated along the cross-section of the sample. Tensile strain appears in the first global Ge layer, compressive strain in the single-step Ge layer and fully strain relaxation in the dual-step Ge layer. The material characterization was locally performed at different points by high resolution transmission electron microscopy, while it was globally performed by high resolution X-ray diffraction and photoluminescence.The effects of reinforcement corrosion and sustained axial load on mechanical performance of reinforced concrete (RC) columns were investigated in the present study. Three different degrees of reinforcement corrosion were achieved by controlling the durations of accelerated corrosion test (i.e., 16 days, 31 days, and 63 days). Three levels of sustained axial load (i.e., 0%, 30%, and 60% of the ultimate bearing capacity) were concentrically applied on column specimens. The impressing current and the sustained load were applied on column specimens simultaneously, mimicking the degradation of RC columns in real structures. Results indicated that transverse stirrups yielded higher corrosion degree than that of the longitudinal rebar under identical duration of accelerated corrosion test. The application of sustained axial load improved the performance of corroded RC columns in terms of the reinforcement corrosion, the ultimate axial load, as well as the stiffness. Additionally, more longitudinal cracks along the main rebar were exhibited for column specimens subjected to sustained axial load. For both loaded and unloaded column specimens, corrosion of reinforcing steels exacerbated the mechanical deterioration of RC columns, lowering the ultimate load carrying capacity and the axial deformation compared to the uncorroded columns.The investigation of the hot filament chemical vapor deposition nanodiamonds with simultaneously embedded luminescent GeV- and SiV- color centers from solid sources showed that both the absolute and relative intensities of their zero-phonon lines (at 602 and 738 nm) depend on nanodiamond growth conditions (a methane concentration in the CH4/H2 gas mixture, growth temperature, and time). It is shown that a controlled choice of parameters of hot filament chemical vapor deposition synthesis makes it possible to select the optimal synthesis conditions for tailoring bicolor fluorescence nanodiamond labels for imaging biological systems.The effect of various heat inputs on the microstructure and impact toughness of the simulated coarse-grained heat-affected zone (CGHAS) of a niobium microalloyed (0.14 wt.%) low-carbon steel was studied. The results showed that higher impact toughness was achieved at a low heat input of 20 kJ/cm, which resulted from the formation of acicular ferrite laths/plates. They sectioned large prior austenite grains into many smaller regions, resulting in smaller crystallographic grains and high-angle grain boundaries. Conversely, when specimens were simulated with larger heat-inputs (100, 200 kJ/cm), the microstructure of the CGHAZ was predominantly composed of granular bainite plus massive MA constituents, thus impairing the impact toughness.This work aimed to analyze the reliability of a steel hall that was recently erected in central Poland subjected to dynamic wind excitation using the stochastic finite element method. Reliability analysis was completed using the relative entropy concept delivered by Bhattacharyya and contrasted with the first-order reliability method recommended by the engineering design codes. Bhattacharyya probabilistic relative entropy was additionally rescaled in this study to fit the demands and recommended admissibility intervals given in Eurocode 0. The finite element method study was carried out thanks to a discrete model created in the system ABAQUS 2019, while all further statistical and probabilistic computations were programmed and completed in the symbolic environment of MAPLE 2019. read more Contrary to most engineering analyses in steel structure areas, this study included the important warping effect while designing the hall ridges and the purlins. Dynamic structural responses were determined via the Hilber-Hughes-Taylor algorithm and their series were numerically obtained for a series of input uncertainty parameters representing several mechanical and environmental quantities. The generalized 10th order iterative stochastic perturbation technique was contrasted in this context with statistical estimators from the Monte Carlo simulations and numerical integration resulting from the semi-analytical approach. The key research finding of this study was an extremely good coincidence between the FORM indices and the rescaled relative probabilistic entropies for the given stochastic excitations, which additionally did not depend on a choice of one of the three proposed numerical approaches.Mechanical properties of undisturbed root-soil composites were investigated through direct shear tests under different cementation concentrations by microbially induced carbonate precipitation (MICP). The results show that MICP has a significant strengthening effect on the undisturbed root-soil composite, and the maximum shear strength increases by about 160% after grouting. The shear strength of root-soil composites increases with the increase in calcium chloride concentration, and the shear strength increases the most when the concentration is 0.75M. Calcium carbonate formed by MICP treatment has cementitious properties, which increases the cohesion and internal friction angle of the root-soil composite by about 400% and 120%, respectively. The results show that it is feasible to solidify slope and control soil erosion together with microbial and vegetation roots. The research results can serve as a scientific basis and reference for the application of MICP technology in vegetation slope protection engineering.BaCe0.2Zr0.6Y0.2O3-δ (BCZY) perovskite electrolytes were synthesized for intermediate-temperature solid oxide fuel cell with a cost-effective and versatile co-precipitation method. The synthesized BCZY electrolytes were sintered at 900, 1000, and 1100 °C to observe the effects of low sintering temperature on the structural, morphological, thermal, and electrical properties of BCZY. All BCZY electrolytes materials exhibited a crystalline perovskite structure and were found to be thermally stable. The crystallinity and conductivity of BCZY electrolyte enhanced with increased sintering temperature, due to the grain growth. At the same time, secondary phases of carbonates were also observed for samples sintered at a temperature lower than 1100 °C. The BCZY sintered at 1100 °C exhibited a density >95%, and a power density of 350 mWcm-2 with open-circuit voltage 1.02 V at 650 °C was observed due its dense and airtight structure. Based on the current investigation, we suggest that the BaCe0.2Zr0.6Y0.2O3-δ perovskite electrolyte sintered at a temperature of 1100 °C is a suitable electrolyte for IT-SOFC.