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of pro-oxidants and antioxidant enzyme activity in relapse and remission confirms ongoing oxidative injury irrelevant of MS clinical presentation.

Neuropathic pain is a type of pain reported in people with Parkinson's disease. There are various scales to evaluate the characteristics of this kind of pain. The purpose of this study was to investigate the psychometric properties of the Neuropathic Pain Symptom Inventory (NPSI), a specific scale that measures neuropathic pain in Iranian people with Parkinson's disease.

Four hundred forty-seven individuals with Parkinson's disease were recruited in the study. Acceptability, internal consistency (Cronbach's alpha), and test-retest reliability (intraclass correlation coefficient, ICC) of NPSI were calculated. Dimensionality was examined through exploratory factor analysis. For convergent validity, correlations of NPSI with Douleur Neuropathic 4, Brief Pain Inventory, King's Pain Parkinson disease Scale, and Visual Analog Scale-Pain were used. Discriminative validity and sensitivity to change between On- and Off- medication states were analyzed.

A marked floor effect was observed for this scale (64.2%). Cronbach's alpha and ICC were 0.90 and 0.87, respectively. Items of NPSI were placed in 4 factors. A moderate to the strong association (r

 = 0.55 to 0.85) between NPSI and other scales was obtained. The results of discriminative validity and sensitivity to change indicate the ability of NPSI to show differences between medication states.

The results of this study suggest that NPSI has acceptable reliability, validity, and sensitivity to change, indicating that this scale is suitable for measuring neuropathic pain in Iranian people with Parkinson's disease.

The results of this study suggest that NPSI has acceptable reliability, validity, and sensitivity to change, indicating that this scale is suitable for measuring neuropathic pain in Iranian people with Parkinson's disease.

The prompt recognition of an acute neurovascular syndrome by the patient or a bystander witnessing the event can directly influence outcome. We aimed to study the predictive value of the medical history and clinical features recognized by the patients' bystanders to preclassify acute stroke syndromes in prehospital settings.

We analyzed 369 patients 209 (56.6%) with acute ischemic stroke (AIS), 107 (29.0%) with intracerebral hemorrhage (ICH), and 53 (14.4%) with subarachnoid hemorrhage (SAH). All patients had neuroimaging as diagnostic gold standard. We constructed clinical prediction rules (CPRs) with features recognized by the bystanders witnessing the stroke onset to classify the acute neurovascular syndromes before final arrival to the emergency room (ER).

In all, 83.2% cases were referred from other centers, and only 16.8% (17.2% in AIS, 15% in ICH, and 18.9% in SAH) had direct ER arrival. The time to first assessment in ≤3h occurred in 72.4% (73.7%, 73.8%, and 64.2%, respectively), and final ER ares, before neuroimaging confirmation.

Uric acid (UA) possesses antioxidant features and potential neuroprotective effects. However, conflicting results regarding the association between serum uric acid (SUA) levels and the prognosis of stroke have been obtained. We aimed to assess whether SUA is related to discharge recovery and short-term outcomes in patients who underwent thrombolysis therapy.

We recruited 393 consecutive patients who were diagnosed with acute ischaemic stroke (AIS) and treated with thrombolysis. The demographic information, including sex and age, was collected. Haematology tests, including SUA, fasting plasma glucose (FPG), and blood lipid parameters, were performed under fasting conditions the morning after admission. The modified Rankin Scale (mRS) was used to assess the functional outcome of patients at discharge and 3 months after onset.

A negative correlation was observed between the levels of SUA and the National Institute of Health Stroke Scale (NIHSS) score at discharge (r = - 0.171, P = 0.003). Additionally, a positive correlation was observed between the levels of SUA and the difference between the baseline NIHSS and discharge NIHSS (r = 0.118, P = 0.032). The levels of SUA in the patients with good outcomes (353.76 ± 93.05) were higher than those in the patients with poor outcomes (301.99 ± 92.24; P = 0.015) at 3 months. The multivariate logistic regression analysis demonstrated that a higher SUA level (odds ratio 0.988, 95% confidence interval 0.985-0.991, P = 0.002) was an independent predictor of a good outcome at 3 months.

Higher SUA levels were associated with better discharge recovery and 3-month outcomes in patients with ischaemic stroke who received thrombolysis.

Higher SUA levels were associated with better discharge recovery and 3-month outcomes in patients with ischaemic stroke who received thrombolysis.

Few data are available on the associations between the level of pre-stroke physical activity and long-term outcomes in patients with stroke. This study is designed to assess the associations between pre-stroke physical activity and age of first-ever stroke occurrence and long-term outcomes.

Six hundred twenty-four cases with first-ever stroke were recruited from the Mashhad Stroke Incidence Study a prospective population-based cohort in Iran. Data on Physical Activity Level (PAL) were collected retrospectively and were available in 395 cases. According to the PAL values, subjects were classified as inactive (PAL < 1.70) and active (PAL ≥ 1.70). Age at onset of stroke was compared between active and inactive groups. Using logistic model, we assessed association between pre-stroke physical activity and long-term (5-year) mortality, recurrence, disability, and functional dependency rates. We used multiple imputation to analyze missing data.

Inactive patients (PAL < 1.70) were more than 6years youngerive.

The aim was to investigate the association between MMP16 rs60298754 and symptoms of Parkinson's disease (PD) in southern Chinese.

Seven hundred forty-five PD patients were recruited in this study. All patients were evaluated by Brief Pain Inventory (BPI), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39), and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded.

The difference of BPI and Parkinson's disease sleep scale (PDSS) between two groups was showed (BPI MMP16 wildtypes 14.73 ± 14.45; MMP16 carriers 10.95 ± 10.67, p 0.002; PDSS MMP16 wildtypes 117.80 ± 21.45; MMP16 carriers 108.40 ± 23.95, p < 0.001). The association of apathy, nocturia, and sensitive to light were found (apathy p 0.001, OR 0.49, 0.32-0.76; nocturia p < 0.001, OR 3.57, 1.90-7.26; sensitive to light p < 0.001, OR 3.99, 2.01-7.74).

MMP16 rs60298754 was associated with the presence of apathy, pain, nocturia, and sensitive to light.

MMP16 rs60298754 was associated with the presence of apathy, pain, nocturia, and sensitive to light.In a glance, observers can evaluate gist characteristics from crowds of faces, such as the average emotional tenor or the average family resemblance. Prior research suggests that high-level ensemble percepts rely on holistic and viewpoint-invariant information. However, it is also possible that feature-based analysis was sufficient to yield successful ensemble percepts in many situations. To confirm that ensemble percepts can be extracted holistically, we asked observers to report the average emotional valence of Mooney face crowds. Mooney faces are two-tone, shadow-defined images that cannot be recognized in a part-based manner. To recognize features in a Mooney face, one must first recognize the image as a face by processing it holistically. Across experiments, we demonstrated that observers successfully extracted the average emotional valence from crowds that were spatially distributed or viewed in a rapid temporal sequence. In a subsequent set of experiments, we maximized holistic processing by including only those Mooney faces that were difficult to recognize when inverted. Under these conditions, participants remained highly sensitive to the average emotional valence of Mooney face crowds. Taken together, these experiments provide evidence that ensemble perception can operate selectively on holistic representations of human faces, even when feature-based information is not readily available.Calibration is the process by which the execution of actions becomes scaled to the (changing) relationship between environmental features and the actor's action capabilities. Though much research has investigated how individuals calibrate to perturbed optic flow, it remains unclear how different experimental factors contribute to the magnitude of calibration transfer. In the present study, we assessed how testing environment (Experiment 1), an adapted pretest-calibration-posttest design (Experiment 2), and bilateral ankle loading (Experiment 3) affected the magnitude of calibration to perturbed optic flow. We found that calibration transferred analogously to real-world and virtual environments. Although the magnitude of calibration transfer found here was greater than that reported by previous researchers, it was evident that calibration occurred rapidly and quickly plateaued, further supporting the claim that calibration is often incomplete despite continued calibration trials. We also saw an asymmetry in calibration magnitude, which may be due to a lack of appropriate perceptual-motor scaling prior to calibration. The implications of these findings for the assessment of distance perception and calibration in real-world and virtual environments are discussed.Observers can adopt attentional control settings that regulate how their attention is drawn to salient stimuli in the environment. Do observers choose their attentional control settings voluntarily, or are they primed in a bottom-up manner based on the stimuli that the observer has recently attended and responded to (i.e., target-selection history)? In the present experiment, we tested these two accounts using a long-term memory attentional control settings paradigm, in which participants memorized images of 18 common visual objects, and then searched for those objects in a spatial blink task. Unbeknownst to participants, we manipulated priming by dividing the set of target objects into two subsets nine objects appeared frequently as targets in the spatial blink task (frequently primed objects), and nine infrequently (infrequently primed objects). We assessed attentional capture by presenting these objects as distractors in the spatial blink task and measuring their effect on task accuracy. We found that both subsets of objects captured attention more than non-studied objects, and frequently primed objects did not capture attention more than infrequently primed objects. Moreover, a follow-up analysis revealed that all studied objects captured attention, even before those objects had appeared as targets in the spatial blink task. These findings suggest that priming through target-selection history plays little-to-no role in long-term memory attentional control settings. Rather, these findings align with a growing body of evidence that attentional control settings are primarily implemented through voluntary control.