Cowanbroch2585

Recently, several deep learning methods have been applied to decoding in task-related fMRI, and their advantages have been exploited in a variety of ways. However, this paradigm is sometimes problematic, due to the difficulty of applying deep learning to high-dimensional data and small sample size conditions. The difficulties in gathering a large amount of data to develop predictive machine learning models with multiple layers from fMRI experiments with complicated designs and tasks are well-recognized. Group-level, multi-voxel pattern analysis with small sample sizes results in low statistical power and large accuracy evaluation errors; failure in such instances is ascribed to the individual variability that risks information leakage, a particular issue when dealing with a limited number of subjects. In this study, using a small-size fMRI dataset evaluating bilingual language switch in a property generation task, we evaluated the relative fit of different deep learning models, incorporating moderate split methods to control the amount of information leakage. Our results indicated that using the session shuffle split as the data folding method, along with the multichannel 2D convolutional neural network (M2DCNN) classifier, recorded the best authentic classification accuracy, which outperformed the efficiency of 3D convolutional neural network (3DCNN). In this manuscript, we discuss the tolerability of within-subject or within-session information leakage, of which the impact is generally considered small but complex and essentially unknown; this requires clarification in future studies.The convolutional neural networks (CNNs) are a powerful tool of image classification that has been widely adopted in applications of automated scene segmentation and identification. However, the mechanisms underlying CNN image classification remain to be elucidated. In this study, we developed a new approach to address this issue by investigating transfer of learning in representative CNNs (AlexNet, VGG, ResNet-101, and Inception-ResNet-v2) on classifying geometric shapes based on local/global features or invariants. While the local features are based on simple components, such as orientation of line segment or whether two lines are parallel, the global features are based on the whole object such as whether an object has a hole or whether an object is inside of another object. Six experiments were conducted to test two hypotheses on CNN shape classification. The first hypothesis is that transfer of learning based on local features is higher than transfer of learning based on global features. The second hypothrk to develop future CNNs. In contrast to the "ImageNet" approach that employs natural images to train and analyze the CNNs, the results show proof of concept for the "ShapeNet" approach that employs well-defined geometric shapes to elucidate the strengths and limitations of the computation in CNN image classification. This "ShapeNet" approach will also provide insights into understanding visual information processing the primate visual systems.Over the past decade there has been a growing interest in the development of parallel hardware systems for simulating large-scale networks of spiking neurons. Compared to other highly-parallel systems, GPU-accelerated solutions have the advantage of a relatively low cost and a great versatility, thanks also to the possibility of using the CUDA-C/C++ programming languages. NeuronGPU is a GPU library for large-scale simulations of spiking neural network models, written in the C++ and CUDA-C++ programming languages, based on a novel spike-delivery algorithm. This library includes simple LIF (leaky-integrate-and-fire) neuron models as well as several multisynapse AdEx (adaptive-exponential-integrate-and-fire) neuron models with current or conductance based synapses, different types of spike generators, tools for recording spikes, state variables and parameters, and it supports user-definable models. The numerical solution of the differential equations of the dynamics of the AdEx models is performed through a parallel implementation, written in CUDA-C++, of the fifth-order Runge-Kutta method with adaptive step-size control. In this work we evaluate the performance of this library on the simulation of a cortical microcircuit model, based on LIF neurons and current-based synapses, and on balanced networks of excitatory and inhibitory neurons, using AdEx or Izhikevich neuron models and conductance-based or current-based synapses. On these models, we will show that the proposed library achieves state-of-the-art performance in terms of simulation time per second of biological activity. In particular, using a single NVIDIA GeForce RTX 2080 Ti GPU board, the full-scale cortical-microcircuit model, which includes about 77,000 neurons and 3 · 108 connections, can be simulated at a speed very close to real time, while the simulation time of a balanced network of 1,000,000 AdEx neurons with 1,000 connections per neuron was about 70 s per second of biological activity.Multiple mechanisms contribute to the generation, propagation, and coordination of the rhythmic patterns necessary for locomotion in Caenorhabditis elegans. Current experiments have focused on two possibilities pacemaker neurons and stretch-receptor feedback. Here, we focus on whether it is possible that a chain of multiple network rhythmic pattern generators in the ventral nerve cord also contribute to locomotion. L-Ascorbic acid 2-phosphate sesquimagnesium mw We use a simulation model to search for parameters of the anatomically constrained ventral nerve cord circuit that, when embodied and situated, can drive forward locomotion on agar, in the absence of pacemaker neurons or stretch-receptor feedback. Systematic exploration of the space of possible solutions reveals that there are multiple configurations that result in locomotion that is consistent with certain aspects of the kinematics of worm locomotion on agar. Analysis of the best solutions reveals that gap junctions between different classes of motorneurons in the ventral nerve cord can play key roles in coordinating the multiple rhythmic pattern generators.