Covingtonbunn6396

0001). HIFU group tumor metastasis (27%) was lower than resected (33%) and control (67%) group metastasis. Ultrasound imaging, gross pathology and histology results supported these outcomes. HIFU procedures had no complications. Rabbit liver tumor ablation using a toroidal HIFU transducer under ultrasound imaging guidance might therefore be an effective intra-operative treatment for localized liver metastases.Innate immune cells can adopt long-term inflammatory phenotypes following brief encounters with exogenous (microbial) or endogenous stimuli. This phenomenon is named trained immunity and can improve host defense against (recurrent) infections. In contrast, trained immunity can also be maladaptive in the context of chronic inflammatory disorders, such as atherosclerosis. Key to future therapeutic exploitation of this mechanism is thorough knowledge of the mechanisms driving trained immunity, which can be used as pharmacological targets. These mechanisms include profound changes in intracellular metabolism, which are closely intertwined with epigenetic reprogramming at the level of histone modifications. Glycolysis, glutamine replenishment of the tricarboxylic acid cycle with accumulation of fumarate, and the mevalonate pathway have all been identified as critical pathways for trained immunity in monocytes and macrophages. In this review, we provide a state-of-the-art overview of how these metabolic pathways interact with epigenetic programs to develop trained immunity.

To examine prescription opioid claims among individuals with traumatic spinal cord injury (SCI) and to identify factors associated with both chronic opioid and chronic high-dose opioid use.

Retrospective cohort study using population-level administrative data.

Ontario, Canada.

Individuals (N=1842) with traumatic SCI between April 1, 2004 and March 31,2015.

Not applicable.

Proportion of cohort with chronic opioid use (≥90d supply) and proportion with chronic high-dose opioid use (≥90d supply exceeding 90 mg morphine equivalent) between April 1, 2016 and March 31, 2017 (observation period).

A total of 1842 individuals with traumatic SCI were identified (74% men), with a median age of 51 years (interquartile range [IQR], 34-64y) and median duration of injury of 6 years (IQR, 4-9y). During the observation period, 35% were dispensed at least 1 opioid and 19.8% received chronic opioids, 39% of whom received more than 90 mg daily (chronic high dose). The median daily morphine equivalent dose was 212 mged by the Canadian opioid guideline. Further research is needed to understand the risk factors associated with chronic, high-dose opioid use in this population.To optimize the operation and maintenance of nuclear power systems, this study presents a remaining useful life (RUL) prediction method for electric valves by combining convolutional auto-encoder (CAE) and long short term memory (LSTM). CAE can extract deeper features and LSTM is efficient in dealing with time-series data. Moreover, by designing a parallel structure between the outputs of CAE and the original data, features fed into the LSTM are enriched. see more Also, network structure and corresponding hyper-parameters are compared to obtain a more suitable model. Moreover, the accuracy of the proposed method is tested and compared with other machine learning algorithms. This work also serves as a critical innovation to enhance the safety and economic operation of nuclear plants and other complex systems.This paper investigates the observer-based output feedback control problem for cyber-physical systems against randomly occurring packet dropout and periodic Denial-of-Service (DoS) attacks. Two independent Bernoulli distribution are employed to model the randomly occurring packet dropout and periodic DoS attacks such that the considered system can be viewed as a stochastic system. Then, by stochastic analysis method, it proves that the closed-loop systems are still stochastically stable and satisfy a specified H∞ performance. The relationship between the disturbance rejection capacity and the success rate of a DoS attacker is also analyzed. Moreover, some novel inequalities and auxiliary matrices are adopted to remove the restrictive conditions on input matrix B and the diagonal structure of Lyapunov function. Finally, three examples are utilized to show the applicability of the proposed method.As unmanned aerial vehicles (UAVs) use global navigation satellite systems for positioning, the openness and weak security of satellite navigation signals make these systems easily falsifiable. By leveraging these characteristics, we propose a path following identification algorithm to gain control of UAVs using navigation spoofing as a countermeasure against illegal activities. Our contribution is threefold. First, we redefine the UAV kinematics model by treating the spoofing signal as wind. Subsequently, the relation between the spoofing signal and UAV heading angle is identified based on a path following algorithm, and the relation accuracy is experimentally verified. Finally, we propose the spoofing sparse A* search (SSAS) algorithm, whose effectiveness is verified by simulations of a UAV directed to a designated area while avoiding obstacles and forbidden areas.

Dyslipidemia is an important risk factor for cardiovascular disease (CVD). Statins are known to effectively reduce not only low-density lipoprotein cholesterol (LDL-C) level but also death and nonfatal myocardial infarction due to coronary heart disease. The risk for CVD from atherogenic dyslipidemia persists when elevated triglyceride (TG) and reduced high-density lipoprotein cholesterol (HDL-C) levels are not controlled with statin therapy. Therefore, statin/fenofibrate combination therapy is more effective in reducing CVD risk. Here, we assessed the efficacy and tolerability of pitavastatin/fenofibrate combination therapy in patients with mixed dyslipidemia and a high risk for CVD.

This multicenter, randomized, double-blind, parallel-group, therapeutic-confirmatory clinical trial evaluated the efficacy and tolerability of fixed-dose combination therapy with pitavastatin/fenofibrate 2/160mg in Korean patients with a high risk for CVD and a controlled LDL-C level (<100mg/dL) and a TG level of 150-500mg/dL after a run-in period with pitavastatin 2mg alone.