Cormierring3014

05). Regarding fracture location, at 2weeks there was no significant difference in the fracture location between the groups, while at 3months, the difference was significant (P < 0.05), the middle root fracture being the most frequent (63.3%).

No significant difference in fracture resistant of simulated immature teeth was observed after 3months when they were filled with Biodentine or WMTA, indicating that Biodentine could be a suitable substitute for MTA. There was no difference in the possible fracture location at 2weeks, while after 3months middle root fractures were more frequent.

No significant difference in fracture resistant of simulated immature teeth was observed after 3 months when they were filled with Biodentine or WMTA, indicating that Biodentine could be a suitable substitute for MTA. There was no difference in the possible fracture location at 2 weeks, while after 3 months middle root fractures were more frequent.

Acute kidney injury (AKI) is frequent in Coronavirus Infection Disease 2019 (COVID-19) patients. Factors associated with AKI in COVID-19 intensive care unit (ICU) patients and their outcomes have not been previously explored.

Prospective observational study of COVID-19 patients admitted to the ICUs of the Hospital Clínic of Barcelona (Spain), from March 25th to April 21st, 2020, who developed AKI stage 2 or higher (AKIN classification). The primary goal was to describe the characteristics of moderate-severe AKI of COVID-19 patients in an ICU context. As a secondary goal, we aimed to find independent predictors of AKI progression, Renal Replacement Therapy (RRT) requirement and mortality among these patients.

During the study period, 52 out of 237 ICU patients, developed AKIN stage 2 or higher and were included in the study. A Sequential Organ Failure Assessment (SOFA) score at AKI diagnosis of 8 or higher was associated with RRT, OR 5.2, p 0.032. At the time of AKI diagnosis, patients had a worse liver profile and higher inflammation markers than at admission. Fifty per cent of the patients presented AKI progression from AKIN 2 to 3 and 28.85% required RRT. The use of corticosteroids in 69.2% of patients was associated with a reduced requirement of RRT, OR 0.13 (CI 95% 0.02-0.89), p 0.037. AKI was associated with high mortality (50%) and a longer hospital stay, median 35 vs 18days (p 0.024).

The prevalence of moderate/severe AKI in COVID-19 patients admitted to the ICU is high and has a strong correlation with mortality and length of hospital stay.

The prevalence of moderate/severe AKI in COVID-19 patients admitted to the ICU is high and has a strong correlation with mortality and length of hospital stay.

The risk of eculizumab therapy discontinuation in patients with atypical hemolytic uremic syndrome (aHUS) is unclear. The main objective of this studywas to analyze the risk of aHUS relapse after eculizumab interruption due to drug shortage in Brazil.

We screened all the registered dialysis centers in Brazil (n = 800), willing to participate in the aHUS Brazilian shortage cohort, through electronic mail and formal invitation by the Brazilian Society of Nephrology. We included patients with aHUS whose eculizumab therapy underwent unplanned discontinuation for at least 30days between January 1st, 2016 and December 31st, 2019 during the maintenance phase of treatment. Relapse was defined by the development of thrombocytopenia, hemolytic anemia, acute kidney injury or thrombotic microangiopathy (TMA) in akidney biopsy.

We analyzed 25episodes of exposure to risk of relapse, from 24 patients. Median age was 33 (6-53) years, 18 (72%) were female, 9 (36%) had a functioning renal graft, 5 (20%) were undergoing dialysis. CFH variant was found in 8 (32%) episodes. There were 11 relapses. The risk of relapse was 34%, 44.5% and 58% at 114, 150 and 397days, respectively. No baseline variable wasrelated to relapse in Cox multivariate analysis, including CFH variant.

In this study, the cumulative incidence of aHUS relapse at 397days was 58% after eculizumab interruption. The presence of complement variant does not seem to be associated with a higher relapse rate. The eculizumab interruption was deemed not safe, considering that the rate of relapse was high.

In this study, the cumulative incidence of aHUS relapse at 397 days was 58% after eculizumab interruption. The presence of complement variant does not seem to be associated with a higher relapse rate. The eculizumab interruption was deemed not safe, considering that the rate of relapse was high.

Autologous arteriovenous fistula (AVF) is the best vascular access for hemodialysis. Distal forearm radiocephalic fistula is the best option, although the primary failure rate ranges from 20% to 50%. The main objective of the PHYSICALFAV trial was to evaluate the effect of preoperative isometric exercise on vascular caliber, percentage of distal arteriovenous fistula, and primary failure rate.

The PHYSICALFAV trial (NCT03213756) is an open-label, multicenter, prospective, randomized, controlled trial (RCT). A total of 138 patients were randomized 11 to the exercise group (exercises combining a handgrip device and an elastic band for 8weeks) or the control group (no exercise) and followed up with periodic Doppler ultrasound (DU) examinations.

After 8weeks of preoperative isometric exercise, in the exercise group,significant increases were detected in venous caliber (2.80 ± 0.95mm vs 3.52 ± 0.93mm [p < 0.001]), arterial caliber (2.61 ± 0.82mm vs 2.74 ± 0.80mm [p = 0.008]), arterial peak systolic velocity (66.34 ± 19.2cm/s vs 71.03 ± 21.5cm/s [p 0.043]), and maximum strength (28.35 ± 9.16kg vs 32.68 ± 10.8kg [p < 0.001]). Diphenhydramine Distal radiocephalic fistulas were performed in 75% of the exercise group patients compared with 50.8% in the control group (p = 0.030). The global primary failure rate was very low in both groups (7% exercise group vs 14% control group [p = 0.373]).

Isometric preoperative exercise can improve vascular caliber and increase the possibility of performing distal arteriovenous fistula, with no significant differences in primary failure rate.

Isometric preoperative exercise can improve vascular caliber and increase the possibility of performing distal arteriovenous fistula, with no significant differences in primary failure rate.