Contrerashorowitz1082

Longitudinal analyses indicated stability of HRS-SR scores over time. Findings indicate that the internet-based HRS-SR is a useful and valid assessment of hoarding symptoms, though additional research using samples with more diverse hoarding behavior is needed to validate optimal cut-off values.The content of AVHs is a major predictor of distress. Although the relationship between mood and AVH content is considered of diagnostic relevance, research investigating the role of depression and anxiety in AVH content remains limited. This study investigated subtypes of negative AVH content, comprising critical, threatening, and self-harm commands in affective and non-affective psychosis. In addition, the study investigated relationships between negative, critical, threatening and self-harm related AVH content and depression and anxiety. Results showed that AVH content did not vary between affective and non-affective psychosis. Among affective voice-hearers, critical, threatening and self-harm content was predicted by anxiety. #link# Whereas in non-affective voice-hearers, self-harm content was predicted by depression. Findings suggest that in affective psychosis, "mood" may be more relevant to whether people hear voices per se, given that by definition voices only arise in mood episodes, whereas anxiety appears to be important in influencing content. In contrast, anxiety and depression may have little influence over voice content in non-affective psychosis, with the exception of depression in self-harm commands. As such, anxiety should be considered in the formulation and treatment of negative AVHs in affective psychosis, and depression in non-affective voice-hearers with self-harm commands.Although many investigators have examined symptoms of major depressive disorder (MDD), the multivariate relations among these features of depression and their relative associations with overall severity of depression are not well understood. The present study is the first to examine the underlying factor structure of depression across a broad set of constructs and to model the multivariate association of these factors with the overall severity of depression. We conducted a large-scale factor analysis and multiple regression in a sample of participants diagnosed with MDD (N = 233) and healthy controls (N = 235). We obtained a five-factor solution composed of the following factors (1) anxiety; (2) behavioral activation; (3) core symptoms; (4) rumination; and (5) emotional intensity. The core symptoms factor, composed primarily of DSM-5 diagnostic criteria for MDD, was the only factor that showed a consistent, significant association with overall severity of depression and functional impairment. Rumination combined with behavioral inhibition and positive and negative affect combined with each other to form coherent constructs that may be useful in examining differences among depressed individuals. These findings provide an important data-driven framework for the multidimensional symptom structure of depression and suggest several actionable ways for improving clinical assessment and treatment for individuals with MDD.Despite growing evidence of the relationship between residential environment and depressive symptoms, little is known about this longitudinal relationship for elderly. Based on the follow-up survey (2011, 2013, and 2015) of the China Health and Retirement Longitudinal Study (CHARLS), this study investigated the association between residential environment and depressive symptoms among Chinese middle- and old-aged adults using repeated measures mixed models and Cox proportional hazards regression models. We found that external building characteristics, indoor space layout, household facilities, and indoor environment have significant effects on depressive symptoms in the elderly. Therefore, residential environment interventions such as external built environments promotion, reasonable indoor space layout, and indoor household facilities and environment improvement can be effective ways to reduce risk of depressive symptoms among Chinese middle- and old-aged adults as well as decrease related public health burden.The current status of knowledge regarding magnetic hybrid structures based on graphene or carbon nanotubes with various forms of iron oxides is reviewed. The paper starts with a summary of the preparation and properties of iron oxide nanoparticles, both untreated and coated with silica or polymer layers. In the next section, organic-inorganic hybrid materials obtained as a result of a combination of graphene or carbon nanotubes and iron chemical compounds are characterized and discussed. These hybrids constitute an increasing percentage of all consumable high performance biomedical, electronic, and energy materials due to their valuable properties and low production costs. check details of their application as components of materials used in corrosion protection, catalysis, spintronics, biomedicine, photoelectrochemical water splitting and groundwater remediation, as well as magnetic nanoparticles in polymer matrices, are also presented. The last part of this review article is focused on reporting the most recent developments in design and the understanding of the properties of polymer composites reinforced with nanometer-sized iron oxide/graphene and iron oxide/carbon nanotubes hybrid fillers. The discussion presents comparative analysis of the magnetic, electromagnetic shielding, electrical, thermal, and mechanical properties of polymer composites with various iron oxide/graphene structures. It is shown that the introduction of hybrid filler nanoparticles into polymer matrices enhances both the macro- and microproperties of final composites as a result of synergistic effects of individual components and the simultaneous formation of an oriented filler network in the polymer. The reinforcing effect is related to the structure and geometry of hybrid nanoparticles applied as a filler, the interactions between the filler particles, their concentration in a composite, and the method of composite processing.Lipids play an important role in human nutrition. Several foodstuffs can be manufactured from the simple, compound and derived lipids. In particular, the use of self-assembled lipids (SLs, e.g. self-assembled L-α-lecithin) has brought great attention for the development of tailored, tuned and targeted colloidal structures loading degradation-sensitive substances with valuable antimicrobial, antioxidant and nutraceutical properties for food applications. For example, polyunsaturated fatty acids (PUFAs) and essential oils can be protected from degradation, thus improving their bioavailability in general terms in consumers. link2 From a nanotechnological point of view, SLs allow the development of advanced and multifaceted architectures, in which each molecule of them are used as building blocks to obtain designed and ordered structures. It is important to note before beginning this review, that simple and compound lipids are the main SLs, while essential fatty acids and derived lipids in general have been considered by many research groups as the bulk loaded substances within several structures from self-assembled carbohydrates, proteins and lipids. However, this review paper is addressed on the analysis of the lipid-lipid self-assembly. Lipids can be self-assembled into various structures (micelles, vesicular systems, lyotropic liquid crystals, oleogels and films) to be used in different food applications coatings, controlled and sustained release materials, emulsions, functional foods, etc. SLs can be obtained via non-covalent chemical interactions, primarily by hydrogen, hydrophilic and ionic bonding, which are influenced by the conditions of ionic strength, pH, temperature, among others. This manuscript aims to give an analysis of the specific state-of-the-art of SLs for food applications, based primarily on the literature reported in the past five years.A novel missense mutation, c.941A > C (p.Y314S), in mitochondrial ubiquinol-cytochrome c reductase core protein I (UQCRC1) gene, was recently identified in a family with autosomal-dominant late-onset parkinsonism and polyneuropathy. link3 UQCRC1 encodes a mitochondria respiratory complex III protein. Mutant UQCRC1 cells showed decreased mitochondrial activity and neurite degeneration. Here, we used the Sendai virus delivery system to generate induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells of a male patient having a heterozygous UQCRC1 p.Y314S mutation. The established iPSCs could differentiate into three germ layers in vivo. This cellular model provides a platform for further studies of UQCRC1-related parkinsonism and polyneuropathy.Ring chromosomes are structural aberrations commonly associated with disease phenotype. We consider necessary to create the iPSCs with a ring chromosome 8, which can be used for disease modeling and related research. The ICGi025-A iPSCs line was obtained by the reprogramming of the skin fibroblasts from a 1-year-old boy with 46,XY,r(8)/45,XY,-8 mosaicism, developmental delay, microcephaly, dysmorphic features, diffuse muscle hypotonia, moderate proximal muscle weakness, feeding problems, and motor alalia. The iPSCs had expression of the pluripotency-associated markers. In vitro differentiated cells expressed the markers of the cells of three germ layers. That data allowed us to conclude that ICGi025-A cells were pluripotent.Extracellular electron transfer via filamentous protein appendages called 'microbial nanowires' has long been studied in Geobacter and other bacteria because of their crucial role in globally-important environmental processes and their applications for bioenergy, biofuels, and bioelectronics. Thousands of papers thought these nanowires as pili without direct evidence. Here, we summarize recent discoveries that could help resolve two decades of confounding observations. Using cryo-electron microscopy with multimodal functional imaging and a suite of electrical, biochemical, and physiological studies, we find that rather than pili, nanowires are composed of cytochromes OmcS and OmcZ that transport electrons via seamless stacking of hemes over micrometers. We discuss the physiological need for two different nanowires and their potential applications for sensing, synthesis, and energy production.

The bed nucleus of the stria terminalis (BNST) plays an important role in rodent posttraumatic stress disorder (PTSD), but evidence to support its relevance to human PTSD is limited. We sought to understand the role of the BNST in human PTSD via fMRI, behavioral, and physiological measurements.

29 patients with PTSD (childhood sexual abuse) and 23 healthy controls (HC) underwent BOLD imaging with an emotional word paradigm. Symptom severity was assessed using the Clinician-Administered PTSD Scale and HPA-axis dysfunction was assessed by measuring the diurnal cortisol amplitude index (DCAI). A data-driven multivariate analysis was used to determine BNST task-based functional co-occurrence (tbFC) across individuals.

In the trauma-versus-neutral word contrast, patients showed increased activation compared to HC in the BNST, medial prefrontal cortex (mPFC), posterior cingulate gyrus (PCG), caudate heads, and midbrain, and decreased activation in dorsolateral prefrontal cortex (DLPFC). Symptom severity positively correlated with activity in the BNST, caudate head, amygdala, hippocampus, dorsal anterior cingulate gyrus (dACG), and PCG, and negatively with activity in the medial orbiotofrontal cortex (mOFC) and DLPFC.