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With the burgeoning of wearable devices and passive body/brain-computer interfaces (B/BCIs), automated stress monitoring in everyday settings has gained significant attention recently, with applications ranging from serious games to clinical monitoring. With mobile users, however, challenges arise due to other overlapping (and potentially confounding) physiological responses (e.g., due to physical activity) that may mask the effects of stress, as well as movement artifacts that can be introduced in the measured signals. For example, the classical increase in heart rate can no longer be attributed solely to stress and could be caused by the activity itself. This makes the development of mobile passive B/BCIs challenging. In this paper, we introduce PASS, a multimodal database of Physical Activity and StresS collected from 48 participants. Participants performed tasks of varying stress levels at three different activity levels and provided quantitative ratings of their perceived stress and fatigue levels. To manipulate stress, two video games (i.e., a calm exploration game and a survival game) were used. Peripheral physical activity (electrocardiography, electrodermal activity, breathing, skin temperature) as well as cerebral activity (electroencephalography) were measured throughout the experiment. A complete description of the experimental protocol is provided and preliminary analyses are performed to investigate the physiological reactions to stress in the presence of physical activity. The PASS database, including raw data and subjective ratings has been made available to the research community at http//musaelab.ca/pass-database/. It is hoped that this database will help advance mobile passive B/BCIs for use in everyday settings.

To assess the safety and efficacy of pre-emptive treatment of optical coherence tomography- (OCT-) derived vulnerable, non-flow-limiting, non-culprit lesions in patients with myocardial infarction (MI).

Intracoronary imaging with OCT can aid in the decision to treat non-flow-limiting lesions by identifying vulnerable plaques. Pre-emptive treatment of these lesions might improve patient outcome by "sealing" these plaques. Bioresorbable vascular scaffolds (BVS) have theoretical benefit for this treatment because they dissolve completely over time.

In patients presenting with MI, non-culprit lesions with a fractional flow reserve ≥0.8 were imaged with OCT. Vulnerable plaques were randomised to either percutaneous coronary intervention (PCI) with bioresorbable vascular scaffold (BVS) placement or optimal medicinal therapy (OMT). The primary outcome was a composite of all-cause mortality, non-fatal MI, and unplanned revascularisation at 1-year follow-up.

The trial was stopped prematurely after retraction fgistered under https//www.trialregister.nl/trial/NL4177 on 08-12-2015.Stream and river restoration practices have become common in many parts of the world. To answer the question whether such restoration measures improve freshwater biotic assemblages or functions over time, and if not, can general reasons be identified for such outcomes, we conducted a literature survey and review of studies in which different types of stream restorations were conducted and outcomes assessed. In the first paper, we reviewed studies of culvert restorations, acid mine drainage or industrial pollution restoration; and urban stream restoration projects. Here, we review studies of restoration via dam removal, changes in dam operation or fish passage structures; instream habitat modification; riparian restoration or woody material addition; channel restoration and multiple restoration measures and develop some general conclusions from these reviews. Biomonitoring in different studies detected improvements for some restoration measures; other studies found minimal or no statistically significant increases in biotic assemblage richness, abundances or functions. In some cases, untreated stressors may have influenced the outcomes of the restoration, but in many cases, there were mismatches in the temporal or spatial scale of the restoration measure undertaken and associated monitoring. For example, either biomonitoring to measure restoration effects was conducted over a too short a time period after restoration for effects to be observed, or the sources and stressors needing remediation occurred at a larger catchment scale than the restoration. Also, many restoration measures lack observations from unimpaired reference sites for use in predicting how much of a beneficial effect might be expected.[This corrects the article DOI 10.1098/rspa.2020.0355.].Social distancing as one of the main non-pharmaceutical interventions can help slow down the spread of diseases, like in the COVID-19 pandemic. Effective social distancing, unless enforced as drastic lockdowns and mandatory cordon sanitaire, requires consistent strict collective adherence. However, it remains unknown what the determinants for the resultant compliance of social distancing and their impact on disease mitigation are. Here, we incorporate into the epidemiological process with an evolutionary game theory model that governs the evolution of social distancing behaviour. In our model, we assume an individual acts in their best interest and their decisions are driven by adaptive social learning of the real-time risk of infection in comparison with the cost of social distancing. FRAX597 price We find interesting oscillatory dynamics of social distancing accompanied with waves of infection. Moreover, the oscillatory dynamics are dampened with a non-trivial dependence on model parameters governing decision-makings and gradually cease when the cumulative infections exceed the herd immunity. Compared to the scenario without social distancing, we quantify the degree to which social distancing mitigates the epidemic and its dependence on individuals' responsiveness and rationality in their behaviour changes. Our work offers new insights into leveraging human behaviour in support of pandemic response.Acoustic actuation techniques offer a promising tool for contactless manipulation of both synthetic and biological micro/nano agents that encompass different length scales. The traditional usage of sound waves has steadily progressed from mid-air manipulation of salt grains to sophisticated techniques that employ nanoparticle flow in microfluidic networks. State-of-the-art in microfabrication and instrumentation have further expanded the outreach of these actuation techniques to autonomous propulsion of micro-agents. In this review article, we provide a universal perspective of the known acoustic micromanipulation technologies in terms of their applications and governing physics. Hereby, we survey these technologies and classify them with regards to passive and active manipulation of agents. These manipulation methods account for both intelligent devices adept at dexterous non-contact handling of micro-agents, and acoustically induced mechanisms for self-propulsion of micro-robots. Moreover, owing to the clinical compliance of ultrasound, we provide future considerations of acoustic manipulation techniques to be fruitfully employed in biological applications that range from label-free drug testing to minimally invasive clinical interventions.