Comptonhernandez4713

We report a case of Argentine hemorrhagic fever diagnosed in a woman in Belgium who traveled from a disease-endemic area. Patient management included supportive care and combination therapy with ribavirin and favipiravir. Of 137 potential contacts, including friends, relatives, and healthcare and laboratory workers, none showed development of clinical symptoms of this disease.BACKGROUND The 2-amino 1,3,4-thiadiazole framework has attracted considerable interest because of its prevalence in compounds possessing a wide range of pharmacological properties including anticancer / antitumor activities. Though a number of methods have been reported for the synthesis of this class of compounds some of them are not straightforward, inexpensive and environmentally friendly. OBJECTIVE To synthesize 2-amino-1,3,4-thiadiazole derivatives that could act as potential anticancer agents. METHODS The use of lemon juice as an inexpensive and readily available biocatalyst was explored in the synthesis of 2-amino 1,3,4- thiadiazole derivatives. Accordingly, a convenient method has been developed for the rapid synthesis of this class of compounds under a mild and non-hazardous reaction condition in good yields. The methodology involved reaction of various acid hydrazides with TMSNCS in the presence of lemon juice in PEG-400 at room temperature (25-30ºC) under ultrasound irradiation. These compounds were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g. MDAMB-231 and MCF-7 and subsequently against SIRT1. RESULTS The 2-amino 1,3,4-thiadiazole derivative 3a, 3i, 3j and 3l showed promising growth inhibition of MDAMB-231 and MCF-7 cell lines and SIRT1 inhibition in vitro. Indeed, 3i was found to be a potent inhibitor of SIRT1. CONCLUSION An ultrasound assisted method facilitated by lemon juice has been developed to synthesize 2-amino-1,3,4-thiadiazole derivatives that could act as potential anticancer agents. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Targeting evolutionarily conserved proteins in malignant cells and the adapter proteins involved in signalling that generates from such proteins may play a cardinal role in the selection of anti-cancer drugs. Drugs targeting these proteins could be of importance in developing anti-cancer drugs. OBJECTIVES We inferred that drugs like loperamide and promethazine that act as antagonists of proteins conserved in cancer cells like voltage-gated Calcium channels (Cav), Calmodulin (CaM) and drug efflux (ABCB1) pump may have the potential to be re-purposed as an anti-cancer agent in Prostate Cancer (PCa). METHODS Growth and cytotoxic assays were performed by selecting loperamide and promethazine to target Cav, CaM and drug efflux (ABCB1) pumps to elucidate their effects on androgen-independent PC3 and DU145 PCa cell lines. RESULT We show that loperamide and promethazine in doses of 80- 100µg/ml exert oncocidal when tested in DU145 and PC3 cell lines. Diphenhydramine which shares its targets with promethazine, except the CaM, failed to exhibit oncocidal effects. CONCLUSION Anti-cancer effects can be of significance if structural analogues of loperamide and promethazine that specifically target Cav, CaM and ABCB1 drug efflux pumps can be synthesized or these two drugs could be re-purposed after human trials in PCa. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Imidazo[1,2-a]pyrimidinone, quinazolinone and amide derivatives have attracted a lot of interest because of their broad scope of biological and pharmacological activities. There are a lot of methods reported in literature for the synthesis of them. Therefore, we became interested in developing a convenient synthetic method for the preparation of imidazoquinazolinone and amide derivatives. OBJECTIVE NiFe2O4@SiO2 @glucose amine were synthesized, characterized and have been used for the green, effective and mild multicomponent synthesis of quinazolinones, benzoimidazo[1,2-a]pyrimidinones and amides under solvent-free condition in short reaction times and excellent yields To expand of the scope of this avenue, multicomponent synthesis of mono and bis novel amides was tested for the first time. All of products were characterized by mp, FT-IR, NMR and elemental analysis. METHOD Aldehyde (1mmol), 2-aminobenzimidazole (1 mmol), dimedone (1mmol) or indane-1,3-dione (1 mmol) for the synthesis of quinazoline tant architecture. The operational simplicity, the excellent yields of products, ease of separation and recyclability of the magnetic catalyst, waste reduction and high selectivity are the main advantages of this method. Furthermore, this new avenue is cheap and environmentally benign. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Sulfonated carbon-based solid acids (CBSAs) has been reported to be an efficient solid acid catalyst for many acid-catalyzed reactions. On the other hand, the use of carbon obtained from biomass waste has been explored, these material show the higher catalytic performance and higher stability versus other solid acids. OBJECTIVE In order to synthesis a biomass carbon-based solid acids nanoparticle with high catalytic activity in organic transformation, Grape pomace waste-SO3H Nano particles (GPW-SO3H NPs) were successfully synthesized. H3B-6527 purchase MATERIALS AND METHOD Grape pomace waste-SO3H Nano particles (GPW-SO3H NPs) were successfully synthesized. The Grape Pomace waste dried in an oven at 70 ° C and was crushing to powder by an electric spice grinder. A mixture of powdered grapes juice waste (1 g) and concentrated sulfuric acid (>98%, 10 mL) were mixed and stirred at room temperature, Then the resultant mixture was transferred into a 100 mL sealed Teflon-lined autoclave and kept at 180 °C for 12 h. After ce.net.BACKGROUND Aripiprazole is a quinolinone derivative. It shows a high affinity for neurotransmitters dopamine and serotonin receptors, which can overcome the blood-brain barrier (BBB) to reach the central nervous system (CNS) to exert therapeutic effects. Its radioiodination may lead to high radiochemical yield and improved its affinity. Aripiprazole radioiodination is an aromatic electrophilic substitution. OBJECTIVE Herein, we investigate the favorable atom site of the aromatic electrophilic substitution of aripiprazole by calculating the Fukui indices of heavy atoms and ESP charges of the parent molecule. METHOD The calculations have been carried out at the B3LYP/LanL2DZ level of theory. The iodinated aripiprazole structure is confirmed by comparing the experimental and the predicted 1H NMR chemical shifts of the parent molecule and its iodinated forms. RESULT Finally, the electronic properties of aripiprazole and its iodinated form were calculated at the same level of theory. Nucleophilic Fukui indices and ESP charges calculations confirm that C8 is the most favorable site of the electrophilic substitution.