Cliffordskovsgaard6990

performances. In general, the SH-SAW sensor with AuNPs shows multifunctional independent characteristics and high-sensitivity performance, making it suitable for a chemical environment, with the possibility of integration with a wireless network.Autonomic self-healing (SH), namely, the ability to repair damages from mechanical stress spontaneously, is polarizing attention in the field of new-generation electrochemical devices. This property is highly attractive to enhance the durability of rechargeable Li-ion batteries (LIBs) or Na-ion batteries (SIBs), where high-performing anode active materials (silicon, phosphorus, etc.) are strongly affected by volume expansion and phase changes upon ion insertion. Here, we applied a SH strategy, based on the dynamic quadruple hydrogen bonding, to nanosized black phosphorus (BP) anodes for Na-ion cells. The goal is to overcome drastic capacity decay and short lifetime, resulting from mechanical damages induced by the volumetric expansion/contraction upon sodiation/desodiation. Specifically, we developed novel ureidopyrimidinone (UPy)-telechelic systems and related blends with poly(ethylene oxide) as novel and green binders alternative to the more conventional ones, such as polyacrylic acid and carboxymethylcellulose, which are typically used in SIBs. BP anodes show impressively improved (more than 6 times) capacity retention when employing the new SH polymeric blend. In particular, the SH electrode still works at a current density higher than 3.5 A g-1, whereas the standard BP electrode exhibits very poor performances already at current densities lower than 0.5 A g-1. This is the result of better adhesion, buffering properties, and spontaneous damage reparation.The optimal therapy effect of tumors is frequently restricted by the dense extracellular matrix (ECM) and anoxia. Herein, an intelligent BPNs-Arg-GOx@MnO2 (BAGM) nanozyme is innovatively designed as a multimodal synergistic therapeutic paradigm that possesses both nitric oxide (NO) self-supplying and ECM degradation properties to reinforce the therapy effect by a tumor microenvironment (TME)-activatable cyclic cascade catalytic reaction. This theranostic nanoplatform is constructed by using polyethyleneimine-modified black phosphorus nanosheets as a "fishnet" to attach l-Arginine (l-Arg) and glucose oxidase (GOx) and then depositing mini-sized MnO2 nanosheets (MNs) on the surface by a facile situ biomineralization method. As an intelligent "switch", the MNs can effectively trigger the cascade reaction by disintegrating intracellular H2O2 to release O2. Then, the conjugated GOx can utilize O2 production to catalyze intracellular glucose to generate H2O2, which not only starves the tumor cells but also promotes oxidation of l-Arg to NO. Thereafter, matrix metalloproteinases will be activated by NO production to degrade the dense ECM and transform matrix collagen into a loose state. In turn, a loose ECM can enhance the accumulation of the BAGM nanozyme and thereby reinforce synergistic photothermal therapy/starvation therapy/NO gas therapy. Both in vitro and in vivo results indicate that the TME-tunable BAGM therapeutic nanoplatform with cascade anticancer property and satisfactory biosecurity shows potential in nanomedicine.Two-dimensional materials such as graphene and transition metal dichalcogenides (TMDCs) have received extensive research interest and investigations in the past decade. In this research, we used a refined opto-thermal Raman technique to explore the thermal transport properties of one popular TMDC material WSe2, in the single-layer (1L), bilayer (2L), and trilayer (3L) forms. This measurement technique is direct without additional processing to the material, and the absorption coefficient of WSe2 is discovered during the measurement process to further increase this technique's precision. By comparing the sample's Raman spectroscopy spectra through two different laser spot sizes, we are able to obtain two parameters-lateral thermal conductivities of 1L-3L WSe2 and the interfacial thermal conductance between 1L-3L WSe2 and the substrate. We also implemented full-atom nonequilibrium molecular dynamics simulations (NEMD) to computationally investigate the thermal conductivities of 1L-3L WSe2 to provide comprehensive evidence and confirm the experimental results. The trend of the layer-dependent lateral thermal conductivities and interfacial thermal conductance of 1L-3L WSe2 is discovered. The room-temperature thermal conductivities for 1L-3L WSe2 are 37 ± 12, 24 ± 12, and 20 ± 6 W/(m·K), respectively. The suspended 1L WSe2 possesses a thermal conductivity of 49 ± 14 W/(m·K). Crucially, the interfacial thermal conductance values between 1L-3L WSe2 and the substrate are found to be 2.95 ± 0.46, 3.45 ± 0.50, and 3.46 ± 0.45 MW/(m2·K), respectively, with a flattened trend starting the 2L, a finding that provides the key information for thermal management and thermoelectric designs.Bacterial infections caused by multi-drug-resistant Gram-negative pathogens pose a serious threat to public health. Gram-negative bacteria are characterized by the enrichment of lipid A-anchored lipopolysaccharide (LPS) or lipooligosaccharide (LOS) in the outer leaflet of their outer membrane. Constitutive biosynthesis of lipid A via the Raetz pathway is essential for bacterial viability and fitness in the human host. The inhibition of early-stage lipid A enzymes such as LpxC not only suppresses the growth of Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter spp., and other clinically important Gram-negative pathogens but also sensitizes these bacteria to other antibiotics. The inhibition of late-stage lipid A enzymes such as LpxH is uniquely advantageous because it has an extra mechanism of bacterial killing through the accumulation of toxic lipid A intermediates, rendering LpxH inhibition additionally lethal to Acinetobacter baumannii. Because essential enzymes of the Raetz pathway have never beencterial infection. We anticipate that continued efforts with structure and ligand dynamics-based lead optimization will ultimately lead to the discovery of LpxC- and LpxH-targeting clinical antibiotics against a broad range of Gram-negative pathogens.Synthesis of three-dimensional photocatalysts offers great potential for chemical conversion and hydrogen generation as appropriate solutions for environmental protection and energy shortage challenges. In this study, the magnetic WO3-x@mesoporous carbon (M-WO3-x@MC) was synthesized through the evaporation-induced self-assembly method applying diatom frustules as a natural template. Then, plasma modification was used to prepare the N-doped M-WO3-x@MC (NM-WO3-x@MC) with enhanced photocatalytic activity and durable performance. The WO3-x was embedded in the conductive MC, which was also partially reduced by the carbon precursor within the heat-treatment procedure. The obtained M-WO3-x@MC was treated by the plasma under an N2 atmosphere for the production of the final photocatalyst containing both the N-doped WO3-x and MC. As a result, the NM-WO3-x@MC had larger surface area (208.4 m2 g-1), narrower band gap (2.3 eV), more visible light harvesting, and confined electron-hole pairs recombination. The H2 generation rates of net WO3 nanorods and NM-WO3-x@MC nanocomposite were estimated as 532 and 2765 μmol g-1 h-1, respectively. Additionally, more than 90% of antibiotics (cephalexin, cefazolin and cephradine) degradation and 76% of total organic carbon elimination were obtained after 120 and 240 min of photocatalytic process under visible light irradiation. Eventually, more than eight intermediates were detected for each antibiotic degradation using the gas chromatography-mass spectrometer method, and based on the obtained results, the possible degradation pathways were suggested.We have demonstrated the active manipulation of metamaterial-induced transparency (MIT) in a terahertz hybrid metamaterial with graphene overlayer under photoexcitation. TGF-beta inhibitor It is found that the introduction of graphene can greatly modify the resonant dips and transparency window through the formed depolarization field around unequal-length double bars to weaken dipole resonances and their destructive interference. Transient control of MIT behaviors is determined by the photogenerated carrier dynamics, which influences the distributions of currents and electric fields in the resonant region to hinder the near-field coupling of two bright modes. Optical modulation depth is sensitive to bar spacing due to an anomalous increased double-bar coupling involving intracell and intercell interaction. Heterointerface formed by the added graphene with substrate could further enhance terahertz response via effective separation of the photoexcited carriers. Theoretical calculation based on the coupled Lorentz oscillator model reveals that the photoinduced terahertz response mainly originates from the coupling and damping in hybrid structures. Our findings could facilitate the development of graphene-based dynamical terahertz modulators and optoelectronic devices.3D printing of hydrogels finds widespread applications in biomedicine and engineering. Artificial cartilages and heart valves, tissue regeneration and soft robots, require high mechanical performance of complex structures. Although many tough hydrogels have been developed, complicated synthesis processes hinder their fabrication in 3D printing. Here, a strategy is proposed to formulate hydrogel inks, which can be printed into various strong and tough particle-based double-network (P-DN) hydrogels of arbitrary shapes without any rheological modifiers. These hydrogel inks consist of microgels and a hydrogel precursor. The microgels are individual highly cross-linked networks. They are prepared by swelling dried microparticles in the hydrogel precursor that consists of monomers, initiators, and cross-linkers. Microgels regulate the rheological properties of the hydrogel ink and enable the direct printing. After printing and curing, the precursor forms a sparsely cross-linked network that integrates the microgels, leading to a P-DN hydrogel. The proposed hydrogel inks allow 3D printing of multifunctional hydrogel structures with high mechanical performance and strong adhesion to diverse materials. This strategy will open new avenues to fabricate multifunctional devices in tissue engineering and soft robotics.Timothy grass pollen is a source of potent allergens. Among them, Phl p 1 and Phl p 5 are thought to be the most important, as a majority of timothy grass-allergic individuals have IgE antibodies directed against these two allergens. The profilin from timothy grass (Phl p 12) has been registered as a minor allergen, with up to 35% of individuals in populations of grass pollen allergic patients showing IgE binding to Phl p 12. Profilins are primarily minor allergens and are known for a high likelihood of co-sensitization as well as cross-reactivity situations caused by their sequence and structure similarity. The crystal structure of Phl p 12.0101 was determined and it revealed that this allergen may form an unusual dimer not previously observed among any profilins. For example, the Phl p 12 dimer has a completely different geometry and interface when compared with the latex profilin (Hev b 8) dimer that has its crystal structure determined. The structure of Phl p 12.0101 is described in the context of allergenic sensitization and allergy diagnostics.