Clayhovgaard9745

Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer's disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness.

Two hundred thirty-six clinically normal (N) and 102 impaired (I) participants from the ADNI cohort were included. Amyloid (global) and tau burden (in entorhinal and inferior temporal cortices) were assessed using positron emission tomography (PET). Self-awareness of memory was assessed using discrepancy indexes of subjective participant-informant ratings, as well as participant-objective scores of memory performance. Subjective and objective values were derived from the Everyday Cognition memory questionnaire and Logical Memory (delayed recall).

Lower awareness (both methods) of memory function was associated with higher levels of pathology in the I group as compared to N. There was a significant effect of tauopathy, but not amyloidosis, on individual complaint, such that higher levels of tau associated with lower awareness.

Impaired self-awareness appears progressively in the evolution of the disease related to AD biomarkers. Discordant subjective and objective measures may be important for clinical consideration.

Impaired self-awareness appears progressively in the evolution of the disease related to AD biomarkers. Discordant subjective and objective measures may be important for clinical consideration.

Evidence about contextual interference in children with brain lesions when practising motor tasks is lacking. selleck kinase inhibitor Our main objective was to evaluate the feasibility of a randomised controlled trial (RCT) comparing blocked with random practice order of an upper limb robotic exergame to improve reaching in children with neuromotor disorders with a pilot trial.

We recruited children with brain lesions and impaired upper limb functions who underwent a 3-week schedule that consisted of baseline assessments, intervention period (participants were randomised to a blocked or random order group), and follow-up assessment. We evaluated ten feasibility criteria, including the practicability of the inclusion/exclusion criteria, recruitment rate, feasibility of randomisation, scheduling procedure, and the participants' programme adherence.

The inclusion/exclusion criteria were not completely feasible as patients who were not able to perform the exergames were included. Twelve participants were recruited, and six datasets were used for analysis. The scheduling and randomisation procedures were generally feasible, but the procedure was only partially feasible for the participants, as some sessions were aborted due to lack of motivation and fatigue.

An RCT following this study protocol is not feasible. We formulated suggestions for future studies that aim to investigate contextual interference as in this pilot study.

ClinicalTrials.gov Identifier NCT02443857 , registered on May 14, 2015.

ClinicalTrials.gov Identifier NCT02443857 , registered on May 14, 2015.

Many studies have evaluated the effects that a lack of resources has in children's physical and cognitive development. Although there are reviews that have focused on applied interventions from different perspectives, there is still a need for a comprehensive review of what has been attempted with these children from the cognitive intervention field. The aim of this paper is to present a protocol for a systematic review collecting randomized controlled trials (RCTs) studies whose purpose was to enhance cognitive development through the implementation of cognitive interventions in children and adolescents (< 18 years old) from low socioeconomic Status (SES) settings.

The following databases will be searched Web of Science (WoS core collection), PsycINFO, Cochrane Central Register of Controlled Trial, ERIC, PubMed, ICTRP and Opengrey Register (System for Information of Grey Literature in Europe). Searches will be adapted for each database. Additionally, the reference list of articles included in the reviote interventions aimed at enhancing cognitive domains in children and adolescents who live in disadvantaged contexts.

This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 16 March 2020 (registration number CDR42020150238).

This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 16 March 2020 (registration number CDR42020150238).

The organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults.

We performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011-2018 database. Because of the skewed distribution, BLL and BCL were Ln-transformed for analysis. Weighted multivariate regressions were performed to evaluate the associations between LnBLL and LnBCL and lumbar BMD. Subgroup analyses were further performed.

A total of 3234 participants aged 20-35 years were included in this study. No significant association between LnBLL and lumbar BMD was found (β = - 5.6, 95%CI - 13.5-2.3). However, in the subgroup analysis stratified by sex, this association became negative in women (β = - 18.2, 95%CI - 29.9- - 6.4). Moreover, this negative association was more prominent in female blacks (β = - 35.5, 95%CI - 63.4- - 7.6). On the other hand, a negative association between LnBCL and lumbar BMD was found (β = - 7.4, 95%CI - 14.0- - 0.8). In the subgroup analysis stratified by sex, this negative association only existed in women (β = - 18.7, 95%CI - 28.0- - 9.5). Moreover, this negative association was more prominent in female whites (β = - 31.1, 95%CI - 46.2- - 16.1).

Our finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.

Our finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.