Christophersenpeters2131

The search will be conducted without geographical or publication date restrictions; however, only papers published in the English language will be sought. Details regarding patients' diets, lifestyles, and characteristics will be assessed. check details We will define the primary outcome to compare CRC patients' immunotherapy responses with their gut microbiota composition. The systematic review methodology does not require ethics approval due to the nature of the study design. The systematic review results will be published in an open-access peer-reviewed journal. PROSPERO ID CRD42021277691.Rational use of medicine (RUM) for all medical conditions is crucial in attaining quality of healthcare and medical care for patients and the community as a whole. However, the actual medicine use pattern is not consistent with that of the World Health Organization (WHO) guideline and is often irrational in many healthcare setting, particularly in developing countries. Thus, the aim of the study was to evaluate rational medicine use based on WHO/International Network of Rational Use of Drugs (INRUD) core drug use indicators in Eritrean National and Regional Referral hospitals. A descriptive and cross-sectional approach was used to conduct the study. A sample of 4800 (600 from each hospital) outpatient prescriptions from all disciplines were systematically reviewed to assess the prescribing indicators. A total of 1600 (200 from each hospital) randomly selected patients were observed for patient indicators and all pharmacy personnel were interviewed to obtain the required information for facility-specific indict none of them had their own medicine list or guideline. In conclusion, majority of WHO stated core drug use indicators were not fulfilled by the eight hospitals. The results of this study suggest that a mix of policies needs to be implemented to make medicines more accessible and used in a more rational way.

WHO states risk communication as the conversation of actual information, guidance, and thoughts between specialists and people fronting risks to their well-being, economic or social safety. As risk communication activities are complex and costly usually, evaluation assessment are the best approach to advance risk communication interventions. This study aims to evaluate the effectiveness of risk communication and the quality of health communication materials developed during the 2019 cholera outbreak at Addis Ababa, Ethiopia.

A community-based parallel mixed design was conducted from May to June 2020 at Addis Ababa. A total of 605 adults were selected randomly from Addis Ketema sub-city and ten purposely selected adults were interviewed for qualitative data. In addition eight health communication materials on cholera were randomly selected for evaluation. The quantitative data were analyzed using SPSS version 25. After audio recorded interviews transcribed verbatim and translated into English the qualitati development process is very important to bring desired effects in disease prevention strategies and for effective emergency responses in the future.

this study revealed the positive effects of risk communication messages in increasing individuals' knowledge. Even though the risk communication spots were found to be simple and easy to understand, the quality of printed materials was low and less attention was given for the risk-communication activities. Thus, strengthening the quality of risk communication and materials development process is very important to bring desired effects in disease prevention strategies and for effective emergency responses in the future.

Retrospective cohort.

Lateral lumbar interbody fusion (LLIF) commonly involves a transpsoas approach. Despite the association between LLIF, postoperative iliopsoas weakness, and iatrogenic neuropraxia, no study has yet examined the effect of psoas or multifidus muscle quality on patient-reported outcomes (PROs).

This study retrospectively reviewed patients who underwent LLIF with 1-year minimum follow-up. Psoas and multifidus muscle qualities were graded on preoperative magnetic resonance imaging using two validated classification systems for muscle atrophy. Average muscle quality was calculated as the mean score from all levels (L1-2 through L5-S1). Univariate and multivariate statistics were utilized to investigate the relationship between psoas/multifidus muscle quality and preoperative, 6-weeks postoperative, and final postoperative PROs.

74 patients (110 levels) with a mean follow-up of 18.71 ± 8.02 months were included for analysis. Greater multifidus atrophy was associated with less improvement outcome measures after LLIF.

In observational studies, venous thromboembolism (VTE) has been associated with Cushing's syndrome and with persistent mental stress, two conditions associated with higher cortisol levels. However, it remains unknown whether high cortisol levels within the usual range are causally associated with VTE risk. We aimed to assess the association between plasma cortisol levels and VTE risk using Mendelian randomization.

Three genetic variants in the SERPINA1/SERPINA6 locus (rs12589136, rs11621961 and rs2749527) were used to proxy plasma cortisol. The associations of the cortisol-associated genetic variants with VTE were acquired from the INVENT (28 907 cases and 157 243 non-cases) and FinnGen (6913 cases and 169 986 non-cases) consortia. Corresponding data for VTE subtypes were available from the FinnGen consortium and UK Biobank. Two-sample Mendelian randomization analyses (inverse-variance weighted method) were performed.

Genetic predisposition to higher plasma cortisol levels was associated with a reduced e are associated with a decreased risk of VTE and that this association may be mediated by blood pressure. This study has implications for the planning of observational studies of cortisol and VTE, suggesting that blood pressure traits should be measured and accounted for.The destruction of the earth's ecosystems is the most pressing issue globally. Carbon emissions account for nearly half of global air pollution. Methane is the primary source of ground-level ozone and a significant source of greenhouse gases (GHGs), with greater warming potential than carbon dioxide emissions. The study examines the impact of the different methane emissions (released by agriculture, energy, and industrial sectors), urbanization, natural resource depletion, and livestock production on carbon emissions in the panel of selected Asian countries for the period of 1971 to 2020. The results show that energy associated methane emissions, livestock production, natural resource depletion, and urbanization are the main detrimental factors of environmental degradation across countries. The causality estimates show the unidirectional relationship running from livestock production and agriculture methane emissions to carbon emissions, from total methane emissions and carbon emissions to urbanization and from urbanization to energy methane emissions and livestock production. The forecasting estimates suggest that total methane emissions, natural resource depletion, and urbanization will likely increase carbon emissions over the next ten years. The study concludes that the energy sector should adopt renewable energy sources in its production process to minimize carbon emissions. Urbanization and excessive resource exploitation must be curtailed to attain carbon neutrality.Climate warming accelerates the hydrological cycle, especially in high-latitude and high-altitude areas. The increase in temperature will increase the amount of snow and glacier melting and change the runoff, which will affect the operations of cascade reservoirs significantly. Therefore, taking the upper reaches of the Yellow River with an alpine climate as an example, we propose an improved SIMHYD-SNOW, which considers the snowmelt runoff process. The impacts of climate changes on the runoff process were revealed based on the SIMHYD-SNOW model using the precipitation and temperature data predicted by the SDSM model. A model for the maximum power generation of the cascade reservoirs in the upper reaches of the Yellow River was constructed to explore the impacts of climate changes on the inter-annual and intra-annual hydropower generation of the cascade reservoirs at different periods in the future. The results show that climate change has changed the spatial and temporal allocation of water resources in this area. The future runoff will decrease during the flood period (July to September) but increase significantly during the non-flood period. The inter-annual and intra-annual hydropower generation under the RCP8.5 climate change scenario is significantly lower than the RCP2.6 and RCP4.5 climate change scenarios, and as the CO2 emission concentration increases, this gap increases significantly. This study can provide technical references for the precise formulation of water resources management under climate change.

Men have traditionally not been fully involved in reproductive health care of their partners, and yet, they play a crucial role in family decision-making and therefore crucial key players in preventing poor pregnancy outcomes. This study aimed to assess prevalence and determinants of male participation in maternal health care and explore male partners' perspective of their involvement in antenatal care at an urban tertiary referral facility.

A mixed-methods study was conducted from October 2018 to January 2019 at Muhimbili National Hospital. A cross-sectional survey of 428 nursing mothers and two focus group discussions of male partners (n = 7 and n = 11) of women attending antenatal clinic and nursing mothers in the post-natal ward were performed. Using SPSS Ver. 23 (IBM, Chicago, IL), frequency distribution tables summarized demographic data and categories of male partners' involvement in antenatal care. Focus group discussions included male partners of age from 24 to 55 years at their first to fifth exm should complement strategies to promote men's involvement in maternal health.

The prevalence of male partners' involvement in antenatal care was relatively high. Men's involvement in antenatal care depended on access to antenatal care education, standards of structure and process of antenatal service and how well their role was defined in the maternal health care system. Interactions and practice in society, employment sector and government health system should complement strategies to promote men's involvement in maternal health.According to Terror Management Theory (TMT), there are three common buffers that minimize the anxiety of mortality salience affirmation of a) one's cultural worldview, b) the self and one's personal values, and c) one's significance in the context of close personal relationships. The current study aimed at examining the contents of memes, which were distributed on social media during the COVID-19 outbreak, to explore the means by which humor buffers against death anxiety. A deductive and inductive thematic analysis captured three means by which humor buffers against death anxiety, a) humor as a means for connecting to cultural worldviews; b) humor as a means for inclusion in group; c) humor as a means to gain a sense of control. These findings are discussed through the theoretical lens of TMT.