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The latter was shown to have a higher affinity for the G4 sequences than for their mutated version. This study sheds light on new RNA G-quadruplexes located in genes dysregulated in Parkinson disease and a new G4-binding protein, GNL1.

High-risk non-muscle invasive urinary bladder cancer (NMIBC) presents an increased risk of progression and cancer death. To reduce these risks, two different treatments are recommended - BCG or radical cystectomy (RC). The purpose of this study is to analyze cancer-specific survival of these two initial treatments.

BladderBaSe links information from the SNRUBC from 1997 to 2014, with a number of national healthcare and demographic registers. BCG was used for 3,862 patients (399 had delayed RC), while 687 had initial RC. Propensity scores were used to match the patients treated with RC and with relevant variables such as age, gender, and tumor stage with the same number treated with BCG (673 each arm). In a further comparison, an instrumental variable analysis using hospital strategy as the instrument was used.

The 5-year cancer-specific survival chance was higher for the BCG group than it was for the initial RC group, 87 vs 71%, respectively. In the population with propensity score matching, 78 died from cancer in the BCG group during follow-up and 162 in the RC group. In the instrumental variable analysis, the multivariate adjusted risk difference of cancer-specific death 2 years after diagnosis was 32 per 100 treated patients, in favor of the BCG group.

BCG therapy had better cancer-specific survival than RC also when two different statistic methods were used to try to control for confounding. A prospective randomized trial will be necessary to rule out that selection is a major factor for the outcome.

BCG therapy had better cancer-specific survival than RC also when two different statistic methods were used to try to control for confounding. A prospective randomized trial will be necessary to rule out that selection is a major factor for the outcome.After being ravished by a bloody civil war in the 1860 s, Venezuela's healthcare system was very precarious. In this context, one particularly bright medical student stood out, José Gregorio Hernández. As part of a program to modernize medicine in Venezuela, José Gregorio was sent on a scholarship to pursue medical studies in Europe. He brought back to Venezuela equipment and medical knowledge in bacteriology and pathophysiology. This was instrumental in laying the foundations for major healthcare modernization in Venezuela. Throughout his life, José Gregorio negotiated his intense Catholic faith, with his scientific leanings as a physician. His untimely tragic death in 1919 elevated him to a saintly status amongst Venezuelans. Consequently, his image became a powerful symbol for practitioners of prescientific medicine.Carl Theodor (1839-1909), a royal Duke in the ruling house of the Kingdom of Bavaria, was born to a life of wealth, privilege, and leisure. As was usual for sons of the nobility, he trained as a military officer. He fought in the Franco-Prussian War (1870-1871) and was decorated for his service in battle. Inspired by the tragedies he observed during the War, he decided to become a physician and received his medical degree from the Ludwig Maximilian University in Munich. After working in general medicine, he embarked on an extensive post-graduate program of study in ophthalmology. Starting in 1880, he practiced ophthalmology full time and devoted his life to his patients. He performed most of his work gratis and he personally underwrote most of the costs for his practice. His wife, the Duchess Marie José (1857-1943), a princess of the royal house of Portugal, was as committed to his medical career and philanthropy as he was, and she served as his assistant in the clinic and the operating room. Her untiring support made it possible for Carl Theodor to maintain his busy schedule. After his death, she established a Foundation to administer his clinic and operating facility in Munich.Prostate cancer is the most common malignancy diagnosed in North American men. Although medical advances have improved survival rates, men treated for prostate cancer experience side-effects that can reduce their work capacity, increase financial stress, and affect their career and/or retirement plans. Working-age males comprise a significant proportion of new prostate cancer diagnoses. It is important, therefore, to understand the connections between prostate cancer and men's work lives. This scoping review aimed to summarize and disseminate current research evidence about the impact of prostate cancer treatment on men's work lives. selleck chemicals llc Electronic databases were searched to identify peer-reviewed articles published between 2006 and 2020 that reported on the impact of prostate cancer treatment on men's work. Following scoping review guidelines, 21 articles that met inclusion criteria were identified and analyzed. Evidence related to the impact of prostate cancer on work was grouped under three themes (1) work outcomes after prostate cancer treatment; (2) return to work considerations, and (3) impact of prostate cancer treatment on men's finances. Findings indicate that men's return to work may be more gradual than expected after prostate cancer treatment. Some men may feel pressured by financial stressors and masculine ideals to resume work. Diverse factors including older age and social benefits appear to play a role in shaping men's work-related plans after prostate cancer treatment. The findings provide direction for future research and offer clinicians a synthesis of current knowledge about the challenges men face in resuming work in the aftermath of prostate cancer treatment.Charles Hewitt Moore, a Fellow of the Royal Society of Medicine, practiced at Middlesex and St. Luke's Hospitals and was administratively active in The Medical and Chirurgical Society. From 1851 to 1868, he demonstrated expertise in general surgery and the lymphatic system; on pelvic deformity and disease; on the vascular system and aneurisms; on the etiology of cancer; and on the neurophysiology of sleep. He subscribed to two principles of medical investigation anomalies can reveal new information; and the propagation of untested theory inhibited medical learning and practice. Translator of the German edition of Rokitansky's Handbook (vol. 3, 1851), Moore wrote twelve papers, three chapters for Holmes' System of Surgery (1860-1862), and two treatises. Renowned in vascular and cancer surgery, he combined ablation with ZnCl2 against cutaneous and breast cancer. Theorizing that ganglionic nerve tissue was involved in the sleep cycle, he anticipated modern investigations into the sleep-related activity of basal ganglia, the only nerve tissue in the brain.