Chandlertobiasen7466

001) and F2R (p  less then  .001) was highly correlated with its mRNA expression. In the poisoning cases, neutrophil percentage was significantly different among the high, middle, and low CSF3R-methylation groups (p = .002). In particular, the neutrophil percentage in the high CSF3R-methylation group (48.10 ± 9.63%) was significantly lower than that in the low CSF3R-methylation group (59.30 ± 6.26%) (p = .012). The correlation coefficient between promoter methylation in CSF3R and the neutrophil percentage was -0.445 (p = .020) in cases and - 0.398 (p = .060) in controls. These results imply that hypermethylation occurs in the CSF3R promoter due to benzene exposure and is significantly associated with a reduction in neutrophils. © 2020 Wiley Periodicals, Inc.AIM To examine the control of cardiovascular risk factors in type 1 diabetes (T1D) registries from the USA and Germany/Austria. MATERIALS AND METHODS Data on individuals aged ≥12 years with T1D for ≥1 year, from the T1D Exchange Clinic Network (T1DX, USA) and the Prospective Diabetes Follow-up Registry (DPV, Germany/Austria) between 1/1/2016 and March 31, 2018 were analyzed. Linear and logistic regression models adjusted for age groups, sex, duration of diabetes, and minority status were used to compare clinical characteristics and achievement of diabetes management targets between registries. RESULTS The cohort included 47 936 patients (T1DX n = 19 442; DPV n = 28 494). Achievement of A1c goals ( less then 7.0% ages 18-65 years; all others less then 7.5%) was better in the DPV for those less then 65 years (all p less then 0.001). However, more older adults (age ≥ 65 years) in the T1DX achieved A1c goal of less then 7.5% compared to DPV (70% vs 50%, p less then 0.001). Frequency of patients with overweight (53% vs 51%, p less then 0.001) and obesity (19% vs 9%, p less then 0.001) was higher in T1DX. Frequency of meeting blood pressure goals (84% vs 66%, p less then 0.001) and lipid goals (73 vs 62%, p less then 0.001) was higher in T1DX; this was observed across all age groups (all p less then 0.001). Few young adults less then 26 years received antihypertensive and lipid lowering medications, respectively, despite indications in both registries (T1DX 5% and 3%, DPV 3% and 1%). CONCLUSION A minority of patients with T1D achieve glycemic targets and the majority are inadequately treated for hypertension and dyslipidemia. This highlights the need for improved diabetes and cardiovascular risk management strategies in T1D. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.AIMS Pinus massoniana is one of the most widely distributed forest plants in China. In this study, we isolated a bacterial endophyte (designated FBS135) from apical buds and needles of P. massoniana. Investigations were performed to understand the effects of the strain on pine growth, its genomic features, and the functions of the plasmids it carries. METHODS AND RESULTS Based on its morphological features and 16S rDNA sequence, strain FBS135 was primarily identified as Pantoea eucalypti. We found that FBS135 not only promoted the growth of P. massoniana seedlings, but also significantly increased the survival rate of pine seedlings. The whole genome of FBS135 was sequenced, which revealed that the bacterium carries one chromosome and four plasmids. Its chromosome is 4,023,751 bp in size and contains dozens of genes involved in plant symbiosis. Curing one of the four plasmids, pPant1, resulted in a decrease in the size of the FBS135 colonies and the loss of the ability to synthesize yellow pigment, indicating that this plasmid may be very important for FBS135. CONCLUSIONS P. eucalypti FBS135 has a genomic basis to be implicated in plant-associated lifestyle and was established to have the capability to promote pine growth. This article is protected by copyright. All rights reserved.Chronic stress has been increasingly linked with aberrations in children's behavioral, cognitive, and social development, yet the effect of chronic physiological stress on neural development during the first year of life is largely unknown. Tatbeclin1 The present study aims to link a physiological index of chronic stress (maternal hair cortisol concentration) to maturational differences in infant functional brain development during the first year of life. Participants were 94 mother-infant dyads. To index chronic physiological stress, maternal hair samples were assayed for the previous three months' cortisol output. To examine the development of brain function during the first year of life, six-to-twelve-month-old infants (N=94) completed a resting electroencephalography (EEG) recording. Infants of mothers with evidence of higher physiological stress showed increased relative low-frequency (theta) power and reduced relative high-frequency (alpha, high-gamma) power, compared to infants of mothers with evidence of low physiological stress. This pattern of findings is consistent with other studies suggesting that early life stress may lead to alterations in patterns of infant brain development. These findings are important given that maturational lags in brain development can be long-lasting and are associated with deficits in cognitive and emotional development. The present research also suggests that reducing maternal physiological stress may be a useful target for future interventions aiming to foster neurodevelopment during the first year of life. This article is protected by copyright. All rights reserved.The garnet electrolyte presents poor wettability with Li metal, resulting in an extremely large interfacial impedance and drastic growth of Li dendrites. Herein, a novel ultra-stable conductive composite interface (CCI) consisting of LiySn alloy and Li3N is in-situ constructed between Li6.4La3Zr1.4Ta0.6O12  (LLZTO) pellet and Li metal by conversion reaction of SnNx  with Li metal at 300 ℃. The LiySn alloy as a continuous and robust bridge between LLZTO and Li metal can effectively reduce the LLZTO/Li interfacial resistance from 4468.0 Ω to 164.8 Ω. Meanwhile, the Li3N as a fast Li ion channel can efficiently transfer Li ions and achieve their uniform distribution at the LLZTO/Li interface. Therefore, the Li/LLZTO@CCI/Li symmetric battery stably cycles for 1200 h without short circuit, and the all-solid-state high-voltage Li/LLZTO@CCI/LiNi0.5Co0.2Mn0.3O2  battery achieves a specific capacity of 161.4 mAh g-1  at 0.25 C with a capacity retention rate of 92.6 % and coulombic efficiency of 100.0% after 200 cycles at 25 ℃.