Carneymarcus2138

disease known to be often unresponsive to antidepressants only. Non-invasiveness, the absence of severe side effects and the possibility of administering it to outpatients at an affordable price make tDCS an important tool in clinical practice.

tDCS as augmentation treatment of an adequate pharmacotherapy is a potential strategy in the management of vascular depression, a disease known to be often unresponsive to antidepressants only. Non-invasiveness, the absence of severe side effects and the possibility of administering it to outpatients at an affordable price make tDCS an important tool in clinical practice.

Anemia and coagulation management, or restrictive transfusion strategy are key points in patient blood management in cardiac surgery. Meanwhile, little consideration has been paid to the kinetics of postoperative bleeding. We designed a prospective observational study on the bleeding kinetics from chest tubes, to assess whether it is possible to predict, within the early postoperative hours, major bleeding at the 12 postoperative hour (H12).

Cardiac surgery adult patients admitted consecutively to the postoperative Intensive Care Unit in a tertiary academic hospital were included from January to June 2016. Blood volume was collected from the chest drains, and major bleeding was defined by bleeding exceeding 90th percentile of the volume distribution at H12. Receiver Operating Characteristics (ROC) curve analysis was performed with hourly bleeding thresholds to find out the best predictor of major bleeding.

In 292 patients, H12 bleeding ranged from 60 to 2190 ml (median 350 ml), and major bleeding has a threshold of 675 ml, and concerned 30 patients. Bleeding volume declined logarithmically, 54% [45-63] within the first 4 hours. Patients with major bleeding had higher bleeding volume every hour (p<0.004). A good predictive value was observed within the first 2 hours (2.73 ml/kg; ROC area under the curve 0.87± 0.04 [0.79-0.94], p< 0.001).

Hourly rate of chest tube blood loss seems quite relevant to predict, within the very first postoperative hours after cardiac surgery, major bleeding at H12. Its early detection may help to improve blood conservation strategy since it may prompt preemptive treatments.

Hourly rate of chest tube blood loss seems quite relevant to predict, within the very first postoperative hours after cardiac surgery, major bleeding at H12. Its early detection may help to improve blood conservation strategy since it may prompt preemptive treatments.

Electrolyte serum disorders are associated with poor outcome in chronic heart failure. The aim of this study sought to identify the main driver of incident hypochloremia in chronic HF (CHF) outpatients and to determine the prognostic value of baseline and incident hypochloremia.

Consecutive CHF outpatients were enrolled and clinical, laboratoristic and echocardiographic evaluations were performed at baseline and repeated yearly in a subgroup of patients. Baseline and incident hypochloremia were evaluated. During an up to 5-year follow-up, all-cause mortality was the primary end-point for outcome.

Among 506 patients enrolled, 120 patients died during follow-up. At baseline, hypochloremia was present in 10% of patients and it was associated with mortality at univariate (HR 3.25; 95%CI 2.04-5.18; p<0.001) and at multivariate analysis (HR 2.14; 95%CI 1.23-3.63; p 0.005) after correction for well-established CHF prognostic markers. Among patients with repeated evaluations and without baseline hypochloremioring and correction of hypochloremia could exert a beneficial effect on prognosis.Spontaneous unilateral orbital haematoma in children is not common and very rarely caused by scurvy. Scurvy is a clinical syndrome with a spectrum of clinical manifestations due to severe prolonged vitamin C deficiency leading to impairment of collagen synthesis over skin, bone, teeth and blood vessels. This paper presents a unique case of a 7- year-old girl with learning difficulty who presented with spontaneous right proptosis due to scurvy. OUL232 Imaging studies suggestive of intra- orbital extraconal haemorrhage. The child was treated with a higher than recommended dose of vitamin C initially in emergency situation. She responded well and discharged without complication. Spontaneous orbital haematoma due to scurvy is very rare with less than 10 cases published in literature. The present case should raise the awareness regarding this forgotten disease and importance of balance nutrition amongst children.

We aimed to reveal evidence of endothelial dysfunction in the development of anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis (DM).

Thirty anti-MDA5 DM patients were enrolled and compared with patients with polymyositis (PM) (n=10) and healthy controls (n=20). The concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), endothelin-1 (ET-1) and von Willebrand factor (vWF) as well as interferon-alpha (IFN-α) and Galcetin-9 in the peripheral blood were tested by enzyme-linked immunosorbent assay (ELISA).

Plasma levels of sICAM-1, sVCAM-1, ET-1 and vWF were higher in the anti-MDA5 DM patients than in either the healthy controls or the PM patients. In the anti-MDA5 DM cohort, the ET-1 and vWF levels were significantly lower in the cases without cutaneous ulcers and ILD than the other cases. There was a strong positive relationship between the concentrations of ET-1 and Galectin-9 in the anti-MDA5 DM group.

Our data suggest that endothelial dysfunction may be involved in the development of anti-MDA5 DM.

Our data suggest that endothelial dysfunction may be involved in the development of anti-MDA5 DM.

Tuberculosis (TB) remains a serious public health concern because it continues devastating communities. This survey was conducted in the sub-district 2 of the Tshwane health district, South Africa. It aimed at determining the influence of patients' living conditions on TB treatment outcomes. Human immunodeficiency virus (HIV) status, food security and exposure to cigarette smoke were considered as living conditions; and cure, death, default, failure and relapse were considered TB treatment outcomes.

Record review using the Aitahealth database, clinic registers as well as a piloted, structured and administered questionnaire.

Convenience sampling applied; 180 respondents were obtained. Tuberculosis respondents with negative HIV status had a cure rate of 67.3% whilst those with positive HIV status had 37%. Tuberculosis respondents with good food security had 45.9% of cure rate. Tuberculosis respondents exposed to cigarette smoke had a death rate of 65.2%, while respondents not exposed to cigarette smoke showed 75% of cure rate.