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Oocytes obtained after the third flushing episode developed into poor quality embryos.

Flushing confers a benefit in mono-follicular IVF cycles in poor responder women but flushing more than four times is futile.

Flushing confers a benefit in mono-follicular IVF cycles in poor responder women but flushing more than four times is futile.

Uterine fibroids are common benign uterine tumours. The three most common surgical treatment approaches for uterine fibroids are laparoscopic, robotic and abdominal myomectomies. Bleeding is a risk with all three approaches. The present study compared post-operative and pregnancy outcomes in patients with bilateral uterine artery occlusion who underwent an abdominal myomectomy, with or without a temporary uterine tourniquet.

This retrospective study included 84 patients with intra-mural fibroids (≥ 5 cm) who underwent an abdominal myomectomy. The patients were divided into two groups according to the use (n = 36) or non-use (n = 48) of a temporary uterine tourniquet, and post-operative and pregnancy outcomes in the tourniquet use and non-use groups were then compared. The association of uterine fibroid removal number (≤ 3 and > 3) with laboratory parameters were also evaluated.

There was a statistically significant difference between the groups with > 3 myomas removed and with a uterine tourniquet applied and not applied in terms of haemoglobin (Hb) drop, haematocrit (Hct) drop, transfusion amounts, operation times and lengths of hospitalization in favour of the uterine tourniquet use group (p = 0.019, p = 0.023, p = 0.012, p = 0.044 and p = 0.036, respectively). Bilateral uterine arterial occlusion using a temporary uterine tourniquet had no negative effects on pregnancy outcomes.

A temporary uterine tourniquet may be an effective method for reducing the amount of perioperative bleeding in patients with multiple, large-sized myomas located close to vascular structures.

A temporary uterine tourniquet may be an effective method for reducing the amount of perioperative bleeding in patients with multiple, large-sized myomas located close to vascular structures.

The aim of this study was to evaluate the efficacy, side-effects and continuation rate of the desogestrel-progestin-only-pill (POP) in postpartum and post-abortive Turkish women its relation with breast-feeding.

In this prospective multicentric study women who delivered (or had surgical abortion) and wanted to receive POP for contraception were recruited to the study. The follow-up visits were scheduled at 3rd, 6th and 9th months.

Overall 7468 women (66.5% postpartum, 33.5% post-abortive) participated in the study. Crenolanib According to the previous visit, the percentage of women who came for a follow-up visit at 3rd, 6th and 9th month was 944(12.6%), 406(43%) and 121(29.8%) respectively. Out of the 7468 women recruited only 6% continued with the method at the end of the 9th month. There was a statistically significant increase in Hb level at the 3rd month when compared to the initial values. The incidence of breastfeeding at all visits was between 54.8% and 68.4%. Oligomenorrhea, spotting and headache were the three leading side-effects. There was no pregnancy among the patients who were followed up.

This study demonstrates that POP is an effective postpartum and post-abortive contraceptive method that has no negative impact on breast-feeding and the change in bleeding patterns is the most common side-effect. However, the possible causes of low contraceptive maintenance rates need to be investigated.

This study demonstrates that POP is an effective postpartum and post-abortive contraceptive method that has no negative impact on breast-feeding and the change in bleeding patterns is the most common side-effect. However, the possible causes of low contraceptive maintenance rates need to be investigated.

The diagnosis of endometrial cancer is made by biopsy sampling with pathological analysis, but it is extremely important to make an accurate diagnosis in order to plan the specific treatment, and we suggest that HE4 in the endometrial tissue and in serum could be tools to make the diagnosis more precise.

Our prospective study compared patients with endometrial cancer against non-endometrial cancer ones, matched with several variables. The inclusion criteria were females older than 18 years old that accepted to participate in the research study but that had never underwent surgery for other oncological pathologies, whether for ovarian, colon, cervical carcinoma or uterine sarcoma, and none of them had received preoperative chemo or radiotherapy; moreover, they could not have any severe renal or liver pathology. All of them had hysterectomy surgery and the endometrium was studied by a pathologist who compared the regular staining with HE4-antibody staining, in addition, there were collected the serum samples previous to the surgery.

Suggest bad correlation between the tissue HE4 in patients with and without carcinoma, however, the serum HE4 is statistically significant in the diagnosis of endometrial carcinoma (median EC= 123.1 U, median NE=64.67 U, p=0.002), although the CA125 level is not significant (p=0.208).

Compared to previous studies our results are quite different in the pathological side, but the serum conclusions are positive and very hopeful as the tumor marker HE4 seems to be able to diagnose endometrial cancer.

Compared to previous studies our results are quite different in the pathological side, but the serum conclusions are positive and very hopeful as the tumor marker HE4 seems to be able to diagnose endometrial cancer.

Ductus venosus blood flow velocity measurements are mandatory in many clinical indications. The evaluation of the flow is performed either by comparing the results with the reference tables or by checking the "a" flow qualitatively as reversed or absent in the spectral waveforms. It is aimed to develop the normal reference ranges in low-risk pregnancies of our population.

Measurements of flow velocities (S, v, D, a) and indexes (PIV, PVIV, a/S, S/a) were performed by a single experienced specialist in 1279 singleton uncomplicated pregnancies between 11 and 40 weeks. The absolute flow velocities (S, v, D, a, Vm_Peak) and indexes (PIV, PVIV, a/S, S/a) are obtained from the spectral waveforms using the equipment producer's preset system. The still images were stored in the picture archiving and communication system.

The predicted reference ranges of the DV blood flow velocities according to the gestational age are shown in tables and graphics. Predicted reference curves based on the 5th and 95th percentiles according to gestational week were plotted and given in tables and figures.

The normal reference ranges for absolute flow velocities and indexes were studied in a tertiary care center. The measurements are performed by a single operator, a specialist certified by FMF, either in the classic patterns of the waveforms, about which there are several studies or in case of the variants of the spectral waveforms, which was published recently, for the first time in the medical literature.

The normal reference ranges for absolute flow velocities and indexes were studied in a tertiary care center. The measurements are performed by a single operator, a specialist certified by FMF, either in the classic patterns of the waveforms, about which there are several studies or in case of the variants of the spectral waveforms, which was published recently, for the first time in the medical literature.Aptima MG required the shortest, and STD6 the longest time to detect MG in clinical samples. RPMG detected MG and macrolide resistance mediating mutations (MRMM) simultaneously. Times were influenced by specimen numbers. MG-positives from the other two assays required increased time for MRMM sequencing.

Although heart failure (HF) is one of the most common conditions affecting the heart, little attention has been placed on the role of arteries in contributing to the progression of this disease. We sought to determine the hemodynamic change of arteries in HF patients subdivided according to left ventricular ejection fraction. The major goal was to establish the active compensatory role of arteries in HF.

Using sphygmography, we systematically studied a cohort of 228 HF patients and 52 healthy controls. We focused on the common carotid as the main elastic artery and the posterior tibial as the main muscular artery. Moreover, we categorized the three HF groups, HFrEF, HFmrEF, HFpEF, into two subgroups (A and B) according to the presence or absence of HF signs at baseline.

We discovered that all the parameters of measured arterial kinetics, i.e., work, power, acceleration, and speed, were significantly increased (p<0.001 by one-way ANOVA) in the groups without HF signs. In contrast, all the arterial kin arteries during HF. Mechanistically, we explain these findings by a dual activity of large arteries accomplished via an active propulsive work and a concurrent hemodynamic suction. These underestimated arterial functions partially compensate for the heart dysfunction in HF, underlining a key interplay between the heart and the vessels. We propose a new paradigm that we define as "heart and vessels failure" that explicitly focuses on both heart and vessels' interaction during the progression of HF.

Granulomatosis with polyangiitis (GPA) patients show increased tendency to thromboembolic phenomena in the active phase of their disease.

To evaluate thrombin generation potential and fibrinolytic plasma activity in GPA patients, both in the active phase and in GPA remission.

Thirty-eight GPA patients were studied; 18 with active GPA and 20 in remission. Control group consisted of 39 healthy subjects similar in age and sex. Plasma thrombogenic potential was assessed using calibrated automated thrombography. Plasma fibrinolytic potential was studied by clot lysis time (CLT). In all subjects, inflammatory markers, thrombomodulin and fibrinolysis proteins were also measured.

In the whole group of GPA patients endogenous thrombin potential was higher by about 25% (P< 0.001), while the CLT was lower by about 20% (P=0.02) as compared to controls. Higher ETP and lower CLT together with elevated levels of thrombomodulin and inflammation markers (C-reactive protein, fibrinogen, factor VIII) were also seen between controls and exacerbation and remission subgroups separately, but not between subgroups. The only parameter which differentiated patients with GPA exacerbation from those in remission was D-dimer (1151 ng/mL; IQR 597.2-2468.7 vs. 340.4 ng/mL; IQR 255.1-500.7; P <0.001), a marker of lysis of intravascularly formed fibrin.

GPA patients show increased prothrombotic state, both at exacerbation and remission phase of disease. This is probably related to ongoing low grade inflammation and endothelial injury. Large, clinical studies would be required to address the need for, and appropriate type of antithrombotic prophylaxis during the course of GPA.

GPA patients show increased prothrombotic state, both at exacerbation and remission phase of disease. This is probably related to ongoing low grade inflammation and endothelial injury. Large, clinical studies would be required to address the need for, and appropriate type of antithrombotic prophylaxis during the course of GPA.