Canturocha4750

Highlights An approach to understand the collective behaviour of cycling points races through principal component analysis was effective for quantifying the configuration of the cyclists.Principal component analysis of the global configuration of the cyclists in the points races revealed the fission-fusion dynamics was characterized by two components. The density of a group and number of groups, and transitions among four states was defined by these two components.State transition probabilities indicate that the group separation states were more frequent in the latter half of the sprint interval, and it was difficult to re-combine the separated groups into one.The riders and coaches need to be aware of the stretching and separation of the group, even if it does not occur immediately before the sprint as the positioning of a cyclist in the group would be important at that time.The treatment of wastewater containing organic pollutants has become a serious issue, and one of the advanced oxidation process, Fenton oxidation is recognized as an ideal way owing to its universality and environmental friendliness, thus efficient and economic catalysts are in great demand. Herein by incorporating Fe2+ containing compound as ligand, a tremella-like iron containing metal-organic framework (TFMOF) was synthesized with zirconium acetate and 1,1'-ferrocene-dicarboxylic acid though a facile solvothermal method. The TFMOF combined the merits of both ferrocene moiety with well dispersed Fe2+ sites in the molecular level and MOF films with large surface areas and exposed sites. And the morphology and crystal structure of TFMOF were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. Moreover, employed as an effective catalyst in Fenton oxidation, over 99%, 95% and 97% of rhodamine B, methyl orange and reactive black V were rapidly degraded without the assistance of additional irradiation, and degradation conditions like pH, H2O2 and initial pollutant concentrations as well as the reaction kinetic was investigated, indicating the hydroxyl radical generated in the presence of TFMOF and H2O2 was able to degrade the pollutants into non-toxic molecular. Besides, the catalytic activity of TFMOF maintained well after three cycles. The good activity and universality of TFMOF make it a promising catalyst for the treatment of wastewater.Condiments are the magical ingredients that make the food present a richer taste. In recent years, due to the increasing consciousness of food safety and human health, much progress has been made in developing rapid and nondestructive techniques for the evaluation of food condiments safety, authentication, and traceability. The potential of spectroscopy techniques, such as near-infrared (NIR), mid-infrared (MIR), Raman, fluorescence, inductively coupled plasma (ICP), and hyperspectral imaging techniques, has been widely enhanced by numerous applications in this field because of their advantages over other analytical techniques. Following a brief introduction of condiment and safety basics, this review mainly focuses on recent vibrational and atomic spectral applications for condiment nondestructive analysis and evaluation, including (1) chemical hazards detection; (2) microbiological hazards detection; and (3) authenticity concerns. The review shows current spectroscopies to be effective tools that will play indispensable roles for food condiment evaluation. In addition, online/real-time applications of these techniques promise to be a huge growth field in the near future.This study aimed to evaluate the effect of a methoxylated fraction from Vellozia dasypus Seub on myeloperoxidase (MPO)-chlorinating activity and subsequent in silico assays for binding profile prediction. Therefore, the ethyl acetate extract of aerial parts from Vellozia dasypus Seub was fractionated on open-column chromatography containing SiO2 and eluted with solvent in crescent polarity to yield a fraction with a mixture of flavonols quercetin 3-O-methyl ether (1) and 6-C-methyl quercetin 3-O-methyl ether (2). Their chemical structures were proposed by HPLC coupled to photodiode array (HPLC-DAD) and mass spectrometer using electrospray ionization multistage analysis (HPLC-MS/MS). The fraction enriched with compounds 1 and 2 inhibited more efficiently the in vitro MPO-chlorinating activity (IC50 = 40 µg/mL) than the ethyl acetate extract (IC50 = 64.0 µg/mL). Molecular docking studies revealed that these compounds interact with MPO active pocket similarly to trifluoromethyl-substituted aromatic hydroxamate, a well-known MPO inhibitor, co-crystallized at the MPO binding site (PDB ID 4C1M). Molecular dynamics trajectories confirmed that these two molecules interact with the MPO binding site with a similar energetic pattern when compared to the crystallographic ligand. Taken together, these data expand the sources of phenolic natural compounds that may be further investigated against inflammation-related diseases.Communicated by Ramaswamy H. Sarma.Background This study explored the correlation between the interleukin-1β gene rs16944 polymorphism and diabetes through epidemiological and follow-up investigations.Methods The study was conducted on 600 subjects with normal glucose metabolism recruited from participants of the Risk Evaluation of cAncers in Chinese type 2 diabeTic Individuals A lONgitudinal (REACTION) study in Luzhou, China in 2011. All subjects received a unified standardized questionnaire, physical examination, laboratory examination, and follow-up in 2016. Subjects were divided into normal glucose metabolism (NC), pre-diabetes (PDM), and type 2 diabetes mellitus (T2DM) groups according to their glucose metabolism after follow-up. The IL-1β gene rs16944 polymorphism was analyzed using the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.Results After follow-up, 386, 156, and 58 cases were observed in the NC, PDM, and T2DM groups, respectively. Serum IL-1β levels were compared to baselines at follow-up in the 3 groups; the difference in the T2DM group was statistically significant. The frequency distributions of the IL-1β gene rs16944 genotypes, i.e., CC, CT, and TT, were significantly different in the 3 groups, and the distributions in the T2DM and NC groups were significantly different. The frequency distributions of the C and T alleles of IL-1β rs16944 were not significantly different. Foscenvivint Logistic regression analysis identified the CC+CT genotype as an independent risk factor for the development of diabetes in patients with normal glucose metabolism (OR = 2.457, 95% CI 1.238-4.877).Conclusions The IL-1β gene rs16944 C/T polymorphism may cause genetic susceptibility to T2DM in the Luzhou population. The CC+CT genotypes may increase T2DM risk.