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05 and 1.60 times higher than those of the control. Total Cd extraction followed the order AES (6 mmol kg-1) > GLDA > NTA > EDTA > IDSA (3 mmol kg-1). Chelating agent treatment significantly increased the activity of antioxidant enzymes and promoted plant growth. The self-degradation of AES significantly reduced soil pH, increased soil Cd activity, and promoted Cd uptake and transportation in maize.Soil/aquifer-based treatment systems improve wastewater effluent quality by removing trace contaminants in the soil and/or aquifer during groundwater recharge. This paper critically reviews these systems with a focus on removing nitrogen, particularly low levels of dissolved organic nitrogen (DON) present in the wastewater effluent. DON in wastewater effluent is a concern because of its contribution to nitrogen concentration in surface or groundwater and its role as a precursor of nitrogenous disinfection by-products, which are harmful to human health. Biodegradation and sorption are the main DON removal mechanisms in the subsurface environment where most of the removal happens in the vadose zone. Different factors such as temperature, redox conditions, retention time, indigenous microbial community, and soil type affect DON removal in soil/aquifer-based treatment systems. Lack of sufficient current knowledge underlines the need for designing lab/field scale systems for further determination of the relative contribution of biodegradation and sorption, optimal hydraulic loading rate, and the relationship between DON characteristics such as functional groups and physiochemical processes and its removal. Future research needs for DON removal in soil/aquifer-based treatment systems are identified.Arbuscular mycorrhizal fungi (AMF) can form a symbiotic relationship with most terrestrial plant roots, promote plant growth, and heavy metal (HM) tolerance and thus plays a crucial role in phytoremediation. However, research on the relationship between colonization level and HM tolerance is limited. In this study, apple (Malus domestica) Gretchen Hagen3 genes MdGH3-2/12 silencing plants were treated with four AMF and Cd combination treatments to determine AMF colonization levels, biomass, Cd accumulation, photosynthesis, fluorescence, reactive oxygen species (ROS) and antioxidant substance accumulation, and Cd uptake, transport and detoxification gene expression levels. link= selleck chemicals Results indicate the greater sensitivity of transgenic plants under AMF inoculation and Cd treatment compared with wild type (WT) via lower AMF colonization levels, biomass accumulation, photosynthetic parameters, and the accumulation and clearance homeostasis of ROS, as well as lower detoxification expression levels and higher Cd uptake and transport expression levels. Our study essentially demonstrates that MdGH3-2/12 plays an important role in Cd stress tolerance by regulating AM colonization in apple.Cadmium (Cd) contamination is easily generated during the mining and manufacturing of barium (Ba). In this study, concentrations of both Ba and Cd in rice, vegetables, pork, fish, drinking water, and soil samples from an active barite mining district were determined. Daily intakes of Ba and Cd, as well as corresponding health risks, were evaluated. The average total daily exposure doses of Cd were 0.0035 and 0.0012 mg/kg BW/day (geometric mean) in the mining zone (MZ) and the chemical plant zone (PZ), respectively. These values significantly exceed the provisional tolerable monthly intake (25 μg/kg BW/month, equal to 0.00083 mg/kg BW/day). link2 Based on the daily exposure doses, vegetable consumption was the most significant Ba exposure route for residents, contributing around 66.1% of the total exposure. In contrast, rice consumption was the major Cd exposure pathway, accounting for about 85.6% of the total exposure. Although the geometric mean (0.17) and 95th percentile (P95, 0.75) of the total hazard quotient (HQ) for Ba were below the acceptable level (1), suggesting that there were no significant health effects caused by Ba exposure, Cd exposure was associated with significant health risks, with the geometric mean of the HQ (1.7) and the P95 (21) well above the acceptable limit (1), indicating the unacceptable non-carcinogenic risk of Cd exposure. In summary, high Cd exposure risk, rather than Ba, was observed for populations living in a large-scale active Ba mining area.The SARS-CoV-2 outbreak, began in late 2019, has caused a worldwide pandemic and shows no signs of slowing. Glucocorticoids (GCs), including dexamethasone (DEX), have been widely used as effective anti-inflammatory and immunosuppressant drugs. In this study, seven GCs had no obvious effect on cell viability of angiotensin converting enzyme 2 (ACE2) high expressed HEK293T cells when concentrations were under 10 μM. Molecular docking results revealed that DEX occupied with active binding site of ACE2 of SARS-CoV-2 spike protein. Surface plasmon resonance (SPR) results showed that KD value between DEX and ACE2 was (9.03 ± 0.78) e-6 M. Cell membrane chromatography (CMC) results uncovered that DEX had a chromatographic retention. DEX was found out to inhibiting the viropexis into ACE2h cells using SARS-CoV-2 spike pseudotyped virus. Therefore, DEX inhibits the entrance of SARS-CoV-2 spike pseudotyped virus into cell by binding to ACE2.Human population growth, climate change, and globalization are accelerating the emergence of novel pathogenic viruses. In the past two decades alone, three such members of the coronavirus family have posed serious threats, spurring intense efforts to understand their biology as a way to identify targetable vulnerabilities. Coronaviruses use a programmed -1 ribosomal frameshift (-1 PRF) mechanism to direct synthesis of their replicase proteins. This is a critical switch in their replication program that can be therapeutically targeted. Here, we discuss how nearly half a century of research into -1 PRF have provided insight into the virological importance of -1 PRF, the molecular mechanisms that drive it, and approaches that can be used to manipulate it towards therapeutic outcomes with particular emphasis on SARS-CoV-2.Coupling of nitrogen removal processes with nitrification (NRn) are vital synergistic nitrogen elimination mechanisms in aquatic environments. However, the effects of antibiotics on NRn are not well known. selleck chemicals In the present work, 20-day continuous-flow experiments combined with 15N tracing techniques and quantitative PCR were performed to simulate the impact of sulfamethoxazole (SMX, a sulfonamide antibiotic) with near in situ concentration on NRn processes in sediments of Yangtze Estuary. Results showed that SMX with near in situ concentration significantly decreased NRn, NRw (uncoupling of nitrogen removal processes with nitrification) and actual nitrogen removal rates via inhibiting nitrogen transformation functional genes (AOB, narG, nirS, nosZ) and anammox 16S rRNA gene, while the coupling links between nitrification and nitrogen removal processes were not broken by the exposure. The proportion of NRn in total nitrogen removal processes decreased by approximately 10% with SMX addition, due to the different ystems.The present study investigates the air pollution pattern over India during the COVID-19 lockdown period (24 March-31 May 2020), pre-lockdown (1-23 March 2020) and the same periods from 2019 using Moderate Resolution Imaging Spectroradiometer (MODIS) Terra aerosol optical depth (AOD) with level 2 (10 km × 10 km) and level 3 (1° × 1° gridded) collection 6.1 Dark Target Deep Blue (DT-DB) aerosol product the Tropospheric Monitoring Instrument (TROPOMI) NO2 and SO2 data with a spatial resolution of 7 km × 3.5 km. We also use long-term average (2000-2017) of AOD for March-May to identify existing hotspot regions and to compare the variations observed in 2019 and 2020. link2 The aim of the present work is to identify the pollution hotspot regions in India that existed during the lockdown and understanding the future projection scenarios reported by previous studies in light of the present findings. We have incorporated Menn-Kendall trend analysis to understand the AOD trends over India and percentage change in AOD, NO2 and SO2 to identify air pollution pattern changes during the lockdown. The results indicate higher air pollution levels over eastern India over the coal-fired power plants clusters. By considering the earlier projected studies, our results suggest that eastern India will have higher levels of air pollution, making it a new hotspot region for air pollution with highest magnitudes.To explore whether lead (Pb)-induced defense responses are responsible for the low root-to-shoot Pb translocation, we exposed saplings of the two contrasting poplar species, Populus × canescens with relatively high root-to-shoot Pb translocation and P. nigra with low Pb translocation, to 0 or 8 mM PbCl2. Pb translocation from the roots to aboveground tissues was lower by 57% in P. nigra than that in P. selleck chemicals link3 × canescens. Lower Pb concentrations in the roots and aerial tissues, greater root biomass, and lower ROS overproduction in the roots were found in P. nigra than those in P. × canescens treated with Pb. P. nigra roots had higher proportions of cell walls (CWs)-bound Pb and water insoluble Pb compounds, and higher transcript levels of some pivotal genes related to Pb vacuolar sequestration, such as phytochelatin synthetase 1.1 (PCS1.1), ATP-binding cassette transporter C1.1 (ABCC1.1) and ABCC3.1 than P. × canescens roots. Pb exposure induced defense responses including increases in the contents of pectin and hemicellulose, and elevated oxalic acid accumulation, and the transcriptional upregulation of PCS1.1, ABCC1.1 and ABCC3.1 in the roots of P. nigra and P. × canescens. These results suggest that the stronger defense barriers in P. nigra roots are probably associated with the lower Pb translocation from the roots to aerial tissues, and that Pb exposure-induced defense responses can enhance the barriers against Pb translocation in poplar roots.In addition to being historically intentionally manufactured as commercial products, polychlorinated biphenyls (PCBs) can be unintentionally released as by-products from industrial processes. Recent studies have emphasized the importance of unintentionally produced PCBs (UP-PCBs) and have even identified them as major contributors to atmospheric PCBs. However, little is known about contributions of UP-PCBs in current soils. In this study, all 209 PCB congeners were analyzed in agricultural soils on a national scale to investigate the influence of unintentional sources on Chinese soil. The concentration of Σ209PCBs in soils across China was in the range of 64.3-4358 pg/g. link3 Four non-Aroclor congeners, i.e., PCB11, PCB44 + 47+65, PCB68, and PCB209, were dominant among all PCBs, averagely accounting for 26.3%, 8.83%, 3.03%, and 2.80% of total PCBs, respectively. PCB11 and PCB209 were found to be higher in East China, while PCB44 + 47+65 and PCB68 were higher in South China. Their spatial distributions were largely dependent on local sources. The results of source apportionment indicated that the legacy of historically produced and used commercial PCB mixtures was the dominant contributor to seven indicator PCBs in Chinese agricultural soils, especially high-chlorinated congeners. However, unintentional sources (i.e., pigment/paint, combustion-related sources, and polymer sealant), which contributed 57.4% of the total PCBs, are controlling PCB burdens in agricultural soils across China.