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liative care.

As Asian populations, Chinese have a lower rate of high-risk gene mutations in venous thrombosis. Therefore, individual patient risk assessment, rather than a "blanket policy", is considered the best thromboembolism prophylaxis for Chinese. The purpose of this study was to evaluate the effectiveness and safety of selective thromboembolism prophylaxis compared with conventional thromboembolism prophylaxis by risk stratification with thromboelastography (TEG) after joint arthroplasty in Chinese.

Between August 2016 to August 2017, Chinese patients who underwent hip or knee arthroplasty were randomly divided into a selective anticoagulation group (SAG) and a conventional anticoagulation group (CAG). Participants and outcome assessors were blinded. In the SAG, an anticoagulant was used when TEG indicated hypercoagulability; while in the CAG, an anticoagulant was regularly used until one month after surgery. Outcome evaluation included effectiveness (defined as the incidence of VTE), and safety (defined as the anticoagulation. Furthermore, the safety of selective anticoagulant prophylaxis was superior to that of conventional anticoagulant prophylaxis.

In Chinese patients who underwent hip or knee arthroplasty, the efficacy of selective anticoagulation using TEG in risk stratification was comparable to that of conventional anticoagulation. Furthermore, the safety of selective anticoagulant prophylaxis was superior to that of conventional anticoagulant prophylaxis.The characterization and treatment of oligometastatic disease (OMD) are rapidly growing areas of research. Consensus statements have recently been developed by European Society for Radiotherapy and Oncology (ESTRO)/American Society for Radiation Oncology (ASTRO) and ESTRO/European Organization for Research and Treatment of Cancer (EORTC) in an effort to harmonize terminology describing OMD. The purpose of this study was to assess patient populations eligible for ongoing clinical trials evaluating stereotactic ablative radiotherapy (SABR) in OMD in the context of key definitions from both statements. Using the clinicaltrials.gov database, a search of ongoing OMD clinical trials evaluating the use of SABR was performed from inception to January 2020, using the keywords "oligometastasis", "stereotactic radiotherapy", and related terms. Results were independently reviewed by two investigators, with discrepancies settled by a third. Information from these trials including study design, population criteria, and prias defined by new consensus statements. Therefore, the applicability of results from these trials should be considered within relevant OMD scenarios.Rearfoot disorders are frequently encountered in clinical practice. #link# We reviewed common rearfoot disorders and present conservative treatments, focusing on shoe modification and the application of insoles or orthoses. Achilles tendinopathy is caused by excessive mechanical loads on the gastrocnemius and soleus muscles. Heel lifts, rocker shoes, and the AirHeel Brace can be used to reduce symptoms. Haglund's deformity is an osseous prominence of the posterosuperior part of the calcaneus bone, the pain from which can be alleviated by reducing pressure on the affected area by appropriately modifying the back of the shoe to prevent contact with the lesion. The pain from retrocalcaneal bursitis can be controlled by lifting the heel and loosening the shoe counter. Plantar fasciitis causes plantar heel pain, and its orthotic treatments include the application of a heel cup, heel pad, heel wedge, Thomas heel, and night splint. Calcaneal stress fractures are generally caused by repetitive loads and occur mainly in sporting activities. Patellar tendon-bearing (PTB) orthoses are helpful in reducing the load on the calcaneal bone. Heel fat pad atrophy refers to the loss of the fat pad that absorbs shock in the heel. To reduce pain caused by heel fat pad atrophy, rocker soles, heel pads, and solid ankle cushion heels (SACHs) may be used. Tarsal tunnel syndrome is caused by compression of the tibial nerve within the tarsal tunnel and its symptoms can be managed by rocker soles, supporting medial arches, Thomas heels, and SACHs. Shoe modification or application of orthoses can be helpful for managing rearfoot pain. However, for the active and wide application of these conservative treatment methods, more clinical studies should be conducted.Acute appendicitis (AA) patients who present with a significantly increased level of D-dimer is not common. We speculated that the increase of D-dimer level was a result of pylephlebitis complication in the appendicitis patient. A 34-year-old man presented to the emergency department with sudden onset of lower quadrant abdomen pain. He was diagnosed with AA and scheduled for a laparoscopic appendectomy. He had a blood pressure of 80-90/30-40 mmHg, heart rate of 120-130/min, and his temperature was 38.3 ℃. Routine blood test demonstrated a significantly elevated D-dimer (14,037 μg/L) with a negative blood gas test, normal ultrasound of the lower limbs, and normal pulmonary and abdominal computer tomography angiography (CTA) scans. Further tests showed a two-fold increase in D-dimer and abnormal hepatic function, indicating pylephlebitis, a rare but serious complication of AA. The patient was subjected to laparoscopic appendectomy, removing the cause of pylephlebitis, and received intravenous broad-spectrum antibiotics for an additional 1 week. The patient had clinical improvement with almost complete normalization of his D-dimer, white blood cell (WBC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), fibrin degradation product (FDP) and platelet (PLT) levels. The patient was fully recovered and discharged from the hospital without any complications. Pylephlebitis secondary to AA is rare and can be easily missed. Fatostatin of D-dimer level provided critical value for pylephlebitis diagnosis.

Gandou decoction (GDD) has been widely used in the treatment of Wilson disease (WD) for decades. It is optimized from the Dahuanghuanglianxiexin decoction, Yinchenhao decoction, and Huanglianjiedu decoction. It was first reported in the Treatise on Febrile and Miscellaneous Diseases and A Handbook of Prescriptions for Emergencies published in the Eastern Han Dynasty and the Eastern Jin Dynasty respectively. Hepatic injury is one of the most severe complications of WD. The current study aimed to explore the hepatic-protection effects of GDD and its exact therapeutic target, with a particular focus on the expression of oxidative stress and the Wnt/β-catenin pathway.

Hepatic injury was induced in a copper-loaded rat model using the intragastric administration of copper(II) sulfate pentahydrate (CuSO4·5H2O). The water extract of GDD (0.4 g/kg/d) was administered twice a day for 4 weeks. Copper content and alanine aminotransferase (ALT) level, structural observation under the microscope, and immunohistochemicaurthermore, GDD rectified the expression of Wnt/β-catenin signal pathway-related proteins in both livers of the copper-loaded and copper-stimulated BRL-3A cell lines.

GDD had apparent therapeutic effects on the hepatic injury of copper-loaded rats and copper-stimulated BRL-3A cells. Its mechanism is related to its regulatory effect on the Wnt/β-catenin pathway rectification and oxidative stress antagonism.

GDD had apparent therapeutic effects on the hepatic injury of copper-loaded rats and copper-stimulated BRL-3A cells. Its mechanism is related to its regulatory effect on the Wnt/β-catenin pathway rectification and oxidative stress antagonism.

Geniposide (GE) is the main component in gardenia fruit. This study aimed to investigate the protective effects and potential mechanisms of GE on dextran sulfate sodium (DSS)-induced colitis in mice and lipopolysaccharide (LPS)-induced RAW 264.7 cells.

The in vivo acute colitis experimental model was established by administering drinking water containing 3% DSS to the mice for 7 days. GE was administered to the mice via oral gavage at 20 and 40 mg/kg for 7 days. Colon length, colon myeloperoxidase (MPO) level, serum and colon malondialdehyde (MDA) levels, and superoxide dismutase (SOD) activity were determined, and histological evaluation was performed. The levels of interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) in the serum and colon were detected. The expression of proteins of the nuclear factor E2 related factor 2 (Nrf-2)/HO-1/ NF-κB pathway in the colon was detected. The in vitro model of LPS-induced RAW 264.7 cells to simulate enteritis model. Cell viability, IL-6, IL-1β, and TNF-αe findings demonstrated that GE ameliorated inflammation and oxidative stress in experimental colitis via modulation of the Nrf-2/HO-1/NF-κB pathway. link2 Thus, GE could serve as a potential therapeutic agent for the treatment of ulcerative colitis (UC).

Cardiovascular diseases are currently prevalent in cardiology and vascular surgery in the hospital. The purpose of this study based on text mining and microarray data analysis was designed to find some existing drugs target to gene and expand the potential new drug indications.

Firstly, we used text mining ("Atherosclerosis") and microarray data analysis (GSE28829) to obtain a common set of genes. link3 Secondly, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis performed to these genes, as well as protein-protein interaction (PPI) network. Then, the significant genes clustered in the PPI network were chose to execute gene-drug interaction analysis for potential drug discovery.

We got 1,788 text mining genes (TMGs) and 275 differentially expressed genes (DEGs) through text mining and data analysis, respectively. Ninety-three genes were duplicated between TMGs and DEGs, in which 89 genes were up-regulated genes and four genes were down regulated. Twenty-three genes clustered in the significant gene module. Lastly, the eight out of 23 genes can target 20 existing drugs.

The findings of these eight genes (VCAM1, CSF1R, C5AR1, CXCR4, CD86, CCR1, ITGB2, TLR8), which were associated with inflammatory response, target to 20 existing drugs may expand drug indications to atherosclerosis-related disease.

The findings of these eight genes (VCAM1, CSF1R, C5AR1, CXCR4, CD86, CCR1, ITGB2, TLR8), which were associated with inflammatory response, target to 20 existing drugs may expand drug indications to atherosclerosis-related disease.

To establish and validate a nomogram to predict liver metastasis in patients with small-cell lung cancer (SCLC).

Information on patients diagnosed with SCLC between 2010 and 2015 was retrospectively retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Risk factors for liver metastasis were identified by logistic regression analyses to construct a nomogram. The predictive accuracy was evaluated by concordance indexes (c-index) and calibration plots, and the comparison of discrimination between the nomogram and other routine staging systems was achieved with the area under receiver operating characteristic curve (AUC) analysis. Decision curve analysis (DCA) was performed to measure the clinical performance of the nomogram.

A total of 12,957 patients met our inclusion criteria and were randomly assigned to training (n=6,479) and validation (n=6,478) sets. The nomogram which was established based on independent clinicopathological factors had poor accuracy, and after other distant metastatic sites were added into the predictive model, the new nomogram displayed better discrimination power, with c-indexes of 0.