Buttthomas9009

diuretic activity and confirmed the folkloric use of Podocarpus falcactus.

Although investigations on different pharmacological activities of the experimental plant,

have been conducted, its folklore use for diuresis has not yet been validated. The current study, therefore, focused on the diuretic activity of aqueous and 80% methanol extracts of

Forssk. leaves in rats.

Rats were randomly assigned into eight groups each consisting of six rats. Test groups received either 100 mg/kg, 200 mg/kg, or 400 mg/kg of aqueous or 80% methanol leaves extract. The negative control group and positive control were treated with 2 mL/100 g of distilled water and furosemide (10 mg/kg), respectively. Thereafter urine volume was recorded every hour until the end of the fifth hour, and cumulative urine volume of each rat was measured. Then, diuretic activity, diuretic index, saliuretic index, natriuretic index and carbonic anhydrase inhibition index in each group were calculated, and results were compared among the groups.

The middle (200 mg/kg) and the highest (400 mg/kg) doses of both extracts significantly increased diuresis at the fifth hour (

<0.001) compared to the negative control, although the diuretic activity was less than that of the positive control. Regarding electrolyte excretion, all dose levels of both extracts showed significant natriuresis (

<0.001) and chloriuresis (

<0.01) compared to the negative control. Aqueous extract displayed more significant diuretic effect than 80% methanol extract. The aqueous and 80% methanol extracts produced alkaline urine.

The crude leaves extracts of

increased urinary excretion and concentration of urinary electrolytes in a dose-dependent manner. These findings are in agreement with the traditional claim for use of

as diuretic agent.

The crude leaves extracts of F. sur increased urinary excretion and concentration of urinary electrolytes in a dose-dependent manner. These findings are in agreement with the traditional claim for use of F. sur as diuretic agent.Carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII are overexpressed in many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation cascade, being present in limited amounts in normal tissues. These enzymes together with many others are involved in the pH regulation and metabolism of hypoxic cancer cells, and were validated as antitumor targets recently. A multitude of targeting strategies against these enzymes have been proposed and are reviewed in this article. The small molecule inhibitors, small molecule drug conjugates (SMDCs), antibody-drug conjugates (ADACs) or cytokine-drug conjugates but not the monoclonal antibodies against CA IX/XII will be discussed. Relevant synthetic chemistry efforts, coupled with a multitude of preclinical studies, demonstrated that CA IX/XII inhibition leads to the inhibition of growth of primary tumors and metastases and depletes cancer stem cell populations, all factors highly relevant in clinical settings. One small molecule inhibitor, sulfonamide SLC-0111, is the most advanced candidate, having completed Phase I and being now in Phase Ib/II clinical trials for the treatment of advanced hypoxic solid tumors.

Inhaled β-agonists have been foundational medications for maintenance COPD management for decades. Through activation of cyclic adenosine monophosphate pathways, these agents relax airway smooth muscle and improve expiratory airflow by relieving bronchospasm and alleviating air trapping and dynamic hyperinflation improving breathlessness, exertional capabilities, and quality of life. β-agonist drug development has discovered drugs with increasing longer durations of action short acting (SABA) (4-6 h), long acting (LABA) (6-12 h), and ultra-long acting (ULABA) (24 h). Three ULABAs, indacaterol, olodaterol, and vilanterol, are approved for clinical treatment of COPD.

This article reviews both clinically approved ULABAs and ULABAs in development.

Indacaterol and olodaterol were originally approved for clinical use as monotherapies for COPD. Vilanterol is the first ULABA to be approved only in combination with other respiratory medications. Although there are many other ULABA's in various stages of developmD clinical characteristics to define study populations and to begin to develop therapies that are trait-specific.

Human papillomavirus molecular detection prevents cervical cancer (CC). To widen its use, cervical-vaginal self-collection devices are proposed. Our aim was to determine the acceptability of self-sampled cervical-vaginal protocol and the reproducibility of results using HPV detection brushes in a low-income Colombian population between 35 and 65 years old.

Cross-sectional study including women classified as medium to high-risk for developing CC by using a short-standardized survey. After receiving instructions, women self-collected a cervical-vaginal sample. Subsequently, a perception survey was conducted.

Four hundred and twenty-three women performed self-collected sampling. The median age was 46.5 years (IQR 40-52), 56.5% were housewives, and 55.1% had finished elementary school. About 99% of the population (n=419) considered that they understood the instructions, 19.4% (n=82) reported having concerns about the self-collected sample, 9.2% (n=39) distrusted the results because of the self-collection, 7vate, resulting in 98% acceptability, and positioning it as an excellent tool for CC prevention.

Anemia is the most common hematological abnormality among children on antiretroviral therapy. In Ethiopia, as far as our search, there are no studies done on the incidence and predictors of anemia among children on antiretroviral therapy. This study aimed to assess the incidence and predictors of anemia among children on antiretroviral therapy, attending antiretroviral therapy care at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, from 2007 to 2017.

A retrospective follow-up study was conducted among 391 children on antiretroviral therapy. Mean survival time for children to be anemia free was estimated. A Log rank test was used to compare survival curves among different independent variables. KRIBB11 cell line The Cox regression model was used. The adjusted hazard ratio (AHR) with a 95% confidence interval (CI) was calculated. P-value ≤0.05 was considered as statically significant.

The overall incidence rate of anemia was 10.5 (95% confidence interval (8.6, 12.8)) per 100 child-year. Being severe-immunosuppressed (AHR=2.