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These results also demonstrate that it is feasible to perform VIMS evaluation using an EEG device with a small number of electrodes.COVID-19 has become a global pandemic caused by the SARS-CoV-2 coronavirus. SARS-CoV-2 shares many similarities with SARS coronavirus (SARS-CoV). A viral replication complex containing non-structural proteins (nsps) is the toolbox for RNA replication and transcription of both coronaviruses. In both cases, the RNA-dependent RNA polymerase (RdRp) domain of the coronaviral replication complex dictates the primary polymerase activity by cooperating with cofactors. The higher transmissibility and mortality due to SARS-CoV-2 are related to its higher RNA replication activity compared to SARS-CoV. The discrepancy between the RNA replication efficiency of SARS-CoV and SARS-CoV-2 can be understood by exploring interactions within their viral replication complexes. Our modeling of molecular interactions within the viral replication complexes of SARS-CoV and SARS-CoV-2 using molecular dynamics simulations suggests that in contrast to SARS-CoVnsp12, SARS-CoV2nsp12 prefers helices as the dominant interacting secondary motifs. The relative differences in nonbonded interactions between nsps could suggest viral RNA replication ability in coronaviruses.

The online version contains supplementary material available at 10.1007/s11837-021-04662-6.

The online version contains supplementary material available at 10.1007/s11837-021-04662-6.This paper deals with the existence of nonnegative solutions for a class of boundary value problems of fractional q-differential equation D q σ c [ k ] ( t ) = w ( t , k ( t ) , c D q ζ [ k ] ( t ) ) with three-point conditions for t ∈ ( 0 , 1 ) on a time scale T t 0 = t t = t 0 q n ∪ 0 , where n ∈ N , t 0 ∈ R , and 0 less then q less then 1 , based on the Leray-Schauder nonlinear alternative and Guo-Krasnoselskii theorem. Moreover, we discuss the existence of nonnegative solutions. Examples involving algorithms and illustrated graphs are presented to demonstrate the validity of our theoretical findings.This study investigates the potential effect of economic policy uncertainty, geopolitical risk, non-oil output, inflation and corporate governance features on insurance companies in Saudi Arabia using quarterly data over the period 2013-2019. More specifically, we apply estimation method panel autoregressive distributed lag (ARDL) to model the long- and short-term relationships. Our empirical results reveal negative short-term effects of geopolitical risk and uncertainty about government economic policy on insurance demand. However, the effect of the latter is not permanent. Our results support the assumed 'demand following theory' in the long-term, which, in turn, is an indication of the fact that the demand for insurance policies is dependent on economic growth and more susceptible to inflation. Our evidence shows that corporate governance has a significant effect on insurance demand in the long term, whereas a Shariah board has no significant impact.

Even though dentistry is becoming a women-dominated profession, this is not translating into the choosing oral and maxillofacial surgery as a specialization. Hence, this study was undertaken to analyse factors impacting the choice of specialization and what impact does presence of role models as an intervention have on the attitudes of these young women on their overall career choice decisions.

This qualitative study was undertaken with the aim of understanding and analyzing the impact of role models on the overall shift in attitude of young women graduate students towards oral and maxillofacial surgery as a specialty.

Eleven women maxillofacial faculties from all over the country participated in this study conducted during the 2020 Pandemic. In this study, through the online teaching programme, the influence of women teaching faculties in the form of role models was statistically analysed on 103 attendees out of 140 who answered the survey questionnaire. The sessions were conducted on Zoom platform in udies of long follow-up are needed. In spite of these drawbacks, the results of this study highlight, with the help of the literature, the important role a woman mentor positively plays in career choice and other aspects of women surgeon's professional life.Hemoadsorption was used in a 59-year-old patient with an acute type A aortic dissection, who was on rivaroxaban and dual antiplatelet therapy with clopidogrel and acetylsalicylic acid. Our aim was to expeditiously remove rivaroxaban preoperatively. After 8 h of hemoadsorption, the rivaroxaban blood plasma concentration (RBPC) did not decrease below 42.1 μg/l. Intraoperatively, hemoadsorption was repeated during extracorporeal circulation. Sixteen hours after surgery and a total of 13 h of hemoadsorption, the RBPC was 40.1 μg/l. see more Thereafter, the RBPC spontaneously decreased to 24.7 μg/l within 14 h. In our patient, hemoadsorption may have enhanced rivaroxaban removal at higher RBPC (cutoff value 40-50 μg/l). At lower RBPC, the removal of rivaroxaban may depend solely on the natural drug elimination process. The evolution of the RBPC under hemoadsorption in vivo warrants a thorough investigation. Further clinical studies are required to assess the effectiveness and limitations of hemoadsorption to preclude a fatal bleeding event in patients with rivaroxaban in need of major emergency surgery.To evaluate the role of routine laboratory biomarkers like C Reactive Protein (CRP), Lactate Dehydrogenase (LDH), Interleukin 6 (IL6), Ferritin, Creatinine, Procalcitonin (PCT), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Serum Albumin, Total Bilirubin (T Bil), High Sensitive Troponin I (hs troponin I), N Terminal-pro B-type Natriuretic Peptide (NT proBNP), Blood Urea Nitrogen (BUN) and Blood Gases in COVID 19 patients who are admitted with SARS CoV-2 positive test results by real-time reverse transcriptase polymerase chain reaction (rRT PCR) in Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute, Mumbai, India. 100 individuals detected with COVID-19 belonging to the age group 12-83 years (median age 62 years) within the period of 1st March 2020 to 10th July 2020 were studied. The case group consisted of 72 males and 28 females. 40 healthy adults without any history or clinical evidence suggestive of COVID-19 and without any comorbidities, like diabetes, hypertension chronic lung disease, cardiac disease, cancer, and immune-compromised individuals were considered as a control group for the study.